DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and CG43707

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001260005.1	Gene:	CG43707 / 33601	FlyBaseID:	FBgn0263846	Length:	2021	Species:	Drosophila melanogaster

Alignment Length:	891	Identity:	167/891 - (18%)
Similarity:	276/891 - (30%)	Gaps:	317/891 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EGSIADEAGLRVEDIIVRINDTAATPL-THDEAHRLIM--------------GSG---------- 75
            :|||..      .::|.|......||| |..:|...||              |.|
  Fly   437 QGSIYP------HEMIYRTQSQDVTPLQTLSDAQNNIMYYKPPPPLLDAHSYGLGMEHLSRTRPS 495

  Fly    76 ----SVFYFGVYRE----NEEDAYECLKKFP----TSEGSLTKSPMPTISPSPTPSLSQLTETTN 128
                :|.|..|...    ||...||. ...|    ||......:.:|.         ..:||::.
  Fly   496 PSEQNVEYVNVNAAAVALNESFDYES-NSLPRRACTSHTDFYSNSLPR---------RHITESSE 550

  Fly   129 ARTPEPEPFVPLPRELAAATMAAPAVEV--------------DVDVLAECRQPMSEVHSEE---- 175
            ..|..      :|.:.:.:.:..|..|.              |.|...|.....|||..|:
  Fly   551 LMTDS------VPLDFSQSHLLPPPSEYCKNDDEDVEEYYDEDEDHPHETESYSSEVCMEQAAQH 609

  Fly   176 --------------KRGDVNGHDAP--GQADEGGLPVENLYLPDLPD--RPCSALSERQEIKLVE 222
                          :|.|:.....|  ||.::            |.|  .|.|:...|.::....
  Fly   610 RRMSMLPQMIDSPFRRDDLRRQSMPVYGQTEK------------LIDGFGPRSSFRRRDKVSCFP 662

  Fly   223 EEIAAVLSGESEVLKEHNVLGVNFY-RIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTF 286
            :|..||    .||..|..:. ::|. .|.|||...:.....:....|:...|::
  Fly   663 DEPPAV----QEVRDEQEIF-IDFKPHISPKPSPKLQLKHRKQHKAEIAMRKMQ----------- 711

  Fly   287 LQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVP 351
                             ::|.|.|..:|:         |.|:::|...|.. ..|:|..:||...
  Fly   712 -----------------QQRMAQAAALTL---------PKPKSQPVEVEVR-KVELEPSDEEEDE 749

  Fly   352 EEVVEPEPEP-----EKDEEPLPTD---SEVPNLEQL--------PETELPDEQPEKSDAPKEVC 400
            :||.|||.|.     :.||:.|.||   .|.|..|.:        |.::..|.|.::|...|...
  Fly   750 DEVSEPEEEDDGEEIDDDEQKLETDLQEDEEPLYENITPCGCRVVPTSDAEDIQDKRSQFRKRSV 814

  Fly   401 EPEVVIQTEPGSPDGNEA----SDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSS 461
            ..:          |..||    :..|.|...|:.|.:|    ..:||            ||.:|:
  Fly   815 SLD----------DDYEAKASETPTPTGLRLPSTPASP----CRDEL------------LANVST 853

  Fly   462 LPSTIQ-------------------STLDAVTKQLAD--------LLPTIK-----LQQQEKQLP 494
            .||:..                   :.|.|..:.::|        |.|:.|     ||.|::...
  Fly   854 YPSSDSLANDNTRDHSDGIWNESQVTVLTAEQRDISDGSYSSNLLLTPSSKRKNLLLQHQQRSSV 918

  Fly   495 QIDENSGNEEQVEEGVTTATNTINTAGETEDAGKD---------ISISGSDNPPVGPCESN---- 546
            ..|.....|:....|:.|....|.|...|......         |:::.|.|..:..|.|:
  Fly   919 DTDALDFEEQSPTYGLQTLPKIIKTPTPTTSRPTSTQPMMPPPAIAVTPSTNQILDSCISSPLPK 983

  Fly   547 -----------------------EDRCDAN-----------DREVAEISRSTDDNRLAKD--KKK 575
                                   :...||:           ..:::|.|.:||:.....|  |:.
  Fly   984 RSMVARGSVPDARQLMFTSGATKQRHSDASFLPMGAADYARSADISECSTNTDEYATCTDTSKRT 1048

  Fly   576 DLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEE---------------------HLVRKNN 619
            .:..:..|.::.......|..:.....|.|:::..|:                     .|.|| :
  Fly  1049 PVSTQSSQLEKTHAGSSFESASSLYSMREDLLQHDEKERDKQTTLTKAQLKSPIGSVAELTRK-S 1112

  Fly   620 PRRSKRAFGPLVPSSERPLVLPGGRRWYRPKDAYNDEFIAETLSAQAELITGSTL--GVNFMKYQ 682
            |..|   ......|...|::   |.....|......:.:|.::::|.::.:...:  ||.    .
  Fly  1113 PSHS---ISSTTSSGSCPVL---GAAIKSPAKESLPQTVASSVTSQMKVSSVECIPPGVK----P 1167

  Fly   683 KPERKIDLNRSEV-YK----YLNPHLDRAPVRGIEVRAPLVAAESD 723
            ||:...:..|||| |.    |.:||.:....:|...:|..:..|.:
  Fly  1168 KPDSISEDERSEVRYSSSGYYESPHEEDDEEQGTRSKARRLRQEDE 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	13/53 (25%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	11/52 (21%)
CG43707	NP_001260005.1	PHA03369	<987..1394	CDD:223061	39/238 (16%)
		PDZ_signaling	1702..1775	CDD:238492
		PH	1792..1894	CDD:278594
		PH-like	1792..1893	CDD:302622
		PH-like	1911..2011	CDD:302622
		PH	1921..2014	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900