DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and PsGEF

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	134/744 - (18%)
Similarity:	225/744 - (30%)	Gaps:	271/744 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPRELAAATMA----APAVEVDV 158
            |...||..:...|.:|.|..|: ...:......:|:|.|  |..|....|.|.    .|.....|
  Fly  1569 PVITGSRLRHLDPPVSVSSLPN-GHCSAGVGGGSPKPLP--PPRRTRVVAQMCQEPPRPKANQQV 1630

  Fly   159 DVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEE 223
            ..:....:....:.|...:|..:| .|.|....||.|.
  Fly  1631 KAIVTITETARIMRSSPTKGSGSG-SATGTGSVGGSPA--------------------------- 1667

  Fly   224 EIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQ 288
                                        |...|.    .|...|:.|..:|..||...|....|:
  Fly  1668 ----------------------------KYAACH----CRCTPEDFTHAQLSPDKMEHQTCKLLE 1700

  Fly   289 RPNRPVPKSKQSLEAER---------RAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEK 344
            .|.:.....:|..|.|:         :.|.|..:...:..|:|::..|.....|  .||...:.|
  Fly  1701 SPKQTTTTLEQKQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVP--PTPDSVLTK 1763

  Fly   345 KE--------------------------EEPVPEEVVEPEPEPEKDEEPLPTDSEVP-------- 375
            ..                          ::| .:.::|..||...||.||  |.|.|
  Fly  1764 TSTHVWDNSGCSSNGGGTSTTSTATTTTKQP-RQAIIENIPEDSCDESPL--DEEPPYRPMSSAL 1825

  Fly   376 -------NLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPIT 433
                   :||:||..:..||..|..|.         :...:|...|||                :
  Fly  1826 RRFGTMSSLEKLPSDDRMDEADELDDD---------LDSFKPNGHDGN----------------S 1865

  Fly   434 PVPVKSEEELALERQLADVQRQLAALSSLPSTI--QSTLDAVTKQLADLLPTIKLQQQEKQLPQI 496
            |...:.:|:...||.|  ||..|.|.||....:  :..........|....:.|:...|:....|
  Fly  1866 PQNEEDDEDADSERAL--VQNDLGASSSSGVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAFI 1928

  Fly   497 DE-----NSGN-------------EEQVEEGVTTATN------TINTAGETEDAGKDISISGSDN 537
            |:     |:|:             :||::|..:.||:      |..:.|:.:|  :|:.:..|:|
  Fly  1929 DKYLGRWNAGDAQQQHQQGTASETDEQMDECTSGATSGEEVWGTPTSGGDNDD--QDLQLINSEN 1991

  Fly   538 PPVGPCESNEDRCDANDREV--------AEISRSTDDNRLAK----------DKKKDLDQEQKQQ 584
            ....|.:|:....|.:|.|:        ..::.||....|.:          :::.:.|:|:.||
  Fly  1992 THSSPTKSSTSLNDDDDTELMMDELLMAPPMTASTIRGLLPRFYRRRLEPLFEEETESDEEKTQQ 2056

  Fly   585 Q------------------------------------------QQQQEPLSE--EQNFKKQKRHD 605
            .                                          .::::|.:|  ::|...:.:.|
  Fly  2057 DSDDIKKGEATTNGHYLEDSAGSSSDSESVPPAPPLVPRPVVPDREEDPSAEGQQENLAMEDQED 2121

  Fly   606 VIEELEEHLVRKNNPRRSKRAFGP-------LVPSS----ERPLVLPGGRRWY----RPKDAYND 655
            :...:|..|     |..:..|.||       |:|::    :.|.||......|    ||.
  Fly  2122 LHSSVERLL-----PNLATSAMGPRPLLTTRLLPTTAIDPQPPAVLVASSCEYLLDQRPS----- 2176

  Fly   656 EFIAETLSAQAELITGSTLGVNFMKYQKP 684
                   |.....:.|.::|...|...:|
  Fly  2177 -------SVPGRDLAGGSIGTTTMTSSRP 2198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	5/32 (16%)
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900