DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Pdzd7

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001099832.2	Gene:	Pdzd7 / 293996	RGDID:	1309882	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	165/890 - (18%)
Similarity:	277/890 - (31%)	Gaps:	314/890 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DNVPWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSG 75
            |:...||.:.||.::...:.|.||..|.:|:|.|::|.|.::..|......::|.:|..::.|..
  Rat   218 DDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQT 282

  Fly    76 SVFY-------FGVYRENEEDAYECLKKF---------PTSEGSLTKSPMPTISPSPTPSLSQLT 124
            .:..       :..|:|...: |..|.:.         |.||.|.:.|...:.:|..:.||
  Rat   283 HIMLTIKETGRYPAYKEMVSE-YCWLDRLSNGVLQQLSPASESSSSVSSYASSAPCSSGSL---- 342

  Fly   125 ETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPG-- 187
                                       |:..:||.:..|  .|.|:              .||
  Rat   343 ---------------------------PSDRMDVCLGPE--DPTSQ--------------GPGWG 364

  Fly   188 --------QADEGGLPVE-------NLYLPDLPDRPCSALSERQ-EIKLVEEEIAAVLSGESEVL 236
                    :.|.||..||       .:.|.|...|.....|.|. :..|.|....|:|...|.
  Rat   365 RADTAMQTEPDMGGSRVETWCSVRPTVILRDTAIRSDGPSSTRHLDSALSESPKTALLLALSR-- 427

  Fly   237 KEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSL 301
                          |:|.:..|...| :|.||..:.|.||...:.:               |.:|
  Rat   428 --------------PRPPITRSQSHL-TLWEEKKQRKKEKSGSSGE---------------KGAL 462

  Fly   302 EAERRAANAYKVTIVKSAPREKSPMPEA--------KPAPKEATPPKEVEKK-EEEPVPEEVV-- 355
            :..:...|.:     ....|:..|..:.        ..:|.:..|..::||. ...||.:.|.
  Rat   463 QRSKTLMNLF-----FKGGRQGRPAGDGHREAWTLDSRSPTKVRPRLDLEKAGSVGPVQKFVTWR 522

  Fly   356 -----------------EPEPE-PEKDEEPLPTDSEVPNLEQLPETELPDEQ------------- 389
                             .|..: |..||:....:|..|.::.|....|.|::
  Rat   523 LRRDRERGRALLSARSGSPSGQGPNVDEQMQAWESRRPLIQDLARRLLTDDEVLAVTRHCSRYVH 587

  Fly   390 -----------------PEKSDAPKEVCEPEVVIQTEPG------SPDGNEASD-------GPAG 424
                             |.|....:::  ..||..|:.|      .|...||.:       ||:.
  Rat   588 EGGVEDLVRPLLAILDRPAKLLLLRDI--RSVVAPTDLGRFDSMVMPVEMEAFEALKSRAVGPSA 650

  Fly   425 A------TPPAEP-ITPVP-------------VKSEEELALERQLADVQRQLAALS----SLPST 465
            .      |||... |||||             ...:|:..:..:|..::..|.|.:    .:|..
  Rat   651 LRPTRQDTPPKRHLITPVPDSRGGFYLLPVNSCSEDEDGEIRERLGGLKVSLGASAPHHKGIPPL 715

  Fly   466 IQSTLDAVTKQLADLLPTIK-----------------------LQQQEKQLP-QIDENSGNEEQV 506
            ....:||.:.:.....|..:                       .||.:.|.| |....|.:..:.
  Rat   716 QDVPVDAFSLRRGACAPPPQPPPVAPRPPRPNWLLTEPPSREDTQQNQNQTPGQSCSRSRSHSRS 780

  Fly   507 EEGVTTATNTINTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDN-RLA 570
            ..|       ..:...::..||......|.:|                   |.|:.:|..| |..
  Rat   781 RSG-------SRSRSRSQGRGKSAGCRRSPSP-------------------APITTATSANGRYH 819

  Fly   571 KDKK------KDLDQEQKQQQQQQQEPLSE--EQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAF 627
            :.:|      :.|| .|..:...:||||..  :|..:.:..:....||....:.|     .|::.
  Rat   820 RPRKARPLLPRPLD-GQVAKVGVRQEPLENGIDQTAEDEAGNATTGELRTVTLSK-----MKQSL 878

  Fly   628 GPL----VPSSERPLV-----LPGGRRWYRPKDAYNDEFIAETLSAQAELITGSTLGVNFMKYQK 683
            |..    :.|..:|:|     .|||.           .|:...|.|..||:......:..:.:|
  Rat   879 GISISGGIESKVQPMVKIEKIFPGGA-----------AFLCRALQAGFELVAVDGESLEQVTHQ- 931

  Fly   684 PERKIDLNRSEVYKYLNPHLDRAPVRGIEVRAP---LVAAESDIR 725
              |.:|..| ..|:    :..|.|:. :.||.|   |:...|::|
  Rat   932 --RAVDTIR-RAYR----NKAREPME-LVVRVPGPGLLPLSSNLR 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	18/63 (29%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	10/45 (22%)
Pdzd7	NP_001099832.2	PDZ_signaling	84..164	CDD:238492
		PDZ_signaling	209..289	CDD:238492	18/70 (26%)
		HN_PDZD7_like	555..632	CDD:259824	11/78 (14%)
		PDZ_signaling	866..954	CDD:238492	22/112 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900