DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and X11L

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	694	Identity:	130/694 - (18%)
Similarity:	225/694 - (32%)	Gaps:	192/694 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 PMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVH 172
            |||...|..:|...::.:.:.:.|..|:...||.....|...||                :...|
  Fly   508 PMPPAPPPSSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAA----------------LGGTH 556

  Fly   173 SEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVL---SGESE 234
            :|:..|  :|.........|.||.:             |.||.||   ..:||.:.|   ..:.|
  Fly   557 TEKSAG--SGLGVTPVTAGGSLPSQ-------------AASEIQE---AMKEIRSALQRAKTQPE 603

  Fly   235 VLKEHNVLGVNFYRIF---------------PKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWS 284
            .||            |               |:.|..:|:....:.:|| ..|.||.|:...|
  Fly   604 KLK------------FCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEE-PDTDLETDRLLGQ-- 653

  Fly   285 TFLQRPNRPVPKSKQSLEAERRAA--NAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEE 347
               ||      ..:|...|::..|  ||.:.|.:.|............|.|...:.|:.......
  Fly   654 ---QR------HDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTATI 709

  Fly   348 EPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQLPETELP------------DEQPEKSDAPKEVC 400
            .......:.|. .|:..:....||..:.:.|:|..|:.|            .::..||...:.:.
  Fly   710 RQGIGTSLTPN-SPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRNKEGLL 773

  Fly   401 EPEVVIQ-----------TE---PGSP-------DGNEASDGPAGATPPAE--PITPVP--VKSE 440
            ||:|:|:           |:   .|.|       ...||........|..|  |.|.|.  :.:|
  Fly   774 EPKVLIEGVLFRARYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALAPEGESQPSTEVDLFISTE 838

  Fly   441 EELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQ 505
            :.:.|...|.::....|.     .||        ..:||:...:.|..:.:.:|    ||    .
  Fly   839 KIMVLNTDLKEIMMDHAL-----RTI--------SYIADIGDLVVLMARRRFVP----NS----V 882

  Fly   506 VEEGVTTATNTINTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRLA 570
            |:..:|:....:.|.|          |...::||..|...:    :...:.:..:..|.:...:|
  Fly   883 VDPSITSPLGDVPTPG----------IGEEESPPKEPLSKH----NRTPKMICHVFESDEAQFIA 933

  Fly   571 KD-------------KKKDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRR 622
            :.             |...::.|...::...||.|:.::.|..:......:||::.:|   .|:.
  Fly   934 QSIGQAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEIFGDELEIFAKKELQKEVV---VPKA 995

  Fly   623 SKRAFGPLVPSSERPLVLPGGRRWYRPKDAYNDEFIAETLSAQA-----ELITGSTL-GVNFMKY 681
            .....|.::..|....:||             ...||..:|:.|     :|..|..| .:|.|..
  Fly   996 KGEILGVVIVESGWGSMLP-------------TVVIANLMSSGAAARCGQLNIGDQLIAINGMSL 1047

  Fly   682 QKPERKIDLNRSEVYKYLNPHLDRAPVRGIEVRAPLVAAESDIR 725
                  :.|..|....|:....::..|:...|..|.|.....:|
  Fly  1048 ------VGLPLSTCQSYIRNAKNQTAVKFTVVPCPPVVEVKILR 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	11/51 (22%)
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	36/213 (17%)
		PDZ_signaling	988..1065	CDD:238492	18/98 (18%)
		PDZ_signaling	1092..1151	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900