DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zasp67 and LNX2

DIOPT Version :9

Sequence 1:NP_648358.2 Gene:Zasp67 / 39148 FlyBaseID:FBgn0036044 Length:730 Species:Drosophila melanogaster
Sequence 2:NP_699202.1 Gene:LNX2 / 222484 HGNCID:20421 Length:690 Species:Homo sapiens


Alignment Length:377 Identity:73/377 - (19%)
Similarity:120/377 - (31%) Gaps:118/377 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 GFRLVGGADYDYPLTVVKVTE----GSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            |..:|||  .:.||..:.:.|    |.||.:..|...|.|:::|:...:.::|:.|..::....:
Human   246 GISIVGG--NETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCN 308

  Fly    77 VFYFGVYRENEEDAYECLKKFPT-----SEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEP 136
            ..:..|.||         ::|..     |:.:..:..:..::.....|..||......||.||..
Human   309 TLHLTVLRE---------RRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGV 364

  Fly   137 FV---------------------------------PLPRELAAATMAAPAVEVDVDVLAECR-QP 167
            |:                                 |   ||||..:.|....|::.:....: ||
Human   365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTP---ELAAQIIQASGERVNLTIARPGKPQP 426

  Fly   168 MSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGE 232
            .:.:.........:.|..|               |....||.|.....|.:...|:.|.      
Human   427 GNTIREAGNHSSSSQHHTP---------------PPYYSRPSSHKDLTQCVTCQEKHIT------ 470

  Fly   233 SEVLKE-HNVLGVN--------------FYRIFPKPGVCMS-------SDVLRSLNEEVTKTKLE 275
              |.|| |..||:.              |....|..| |::       .|||.::| .:..|.|.
Human   471 --VKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHG-CLARDGRIKRGDVLLNIN-GIDLTNLS 531

  Fly   276 KDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMP 327
            .              :..|...|.|..:...|..|.:|.||:.|.:.....|
Human   532 H--------------SEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQP 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zasp67NP_648358.2 PDZ_signaling 2..75 CDD:238492 16/62 (26%)
DUF4749 653..>699 CDD:292558
LNX2NP_699202.1 mRING-HC-C3HC3D_LNX2 45..89 CDD:319694
modified RING-HC finger (C3HC3D-type) 50..87 CDD:319694
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 198..224
NPXY motif 208..211
PDZ 230..316 CDD:214570 17/71 (24%)
PDZ 336..422 CDD:214570 15/88 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 418..455 7/51 (14%)
PDZ_signaling 466..542 CDD:238492 20/99 (20%)
PDZ_signaling 599..683 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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