DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Pdlim2

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001240665.1	Gene:	Pdlim2 / 213019	MGIID:	2384850	Length:	349	Species:	Mus musculus

Alignment Length:	370	Identity:	91/370 - (24%)
Similarity:	127/370 - (34%)	Gaps:	145/370 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            |||||:.||.|:..|:.|.||||...|:.|.||..||||.||..:|..:.|.||...|..|.|..
Mouse    12 PWGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGQSAENMLHAEAQSKIRQSASPL 76

  Fly    79 YFGVYRE--------NEEDAYECL-----------KKFPTSEGSLTKSPMPTISPSPTPSLSQLT 124
            ...:.|.        |.|.:.|.|           :...:|:.|...||: ::||.|....|
Mouse    77 RLQLDRSQTASPGQTNGEGSLEVLATRFQGSLRTHRDSQSSQRSACFSPV-SLSPRPCSPFS--- 137

  Fly   125 ETTNARTPEPEPFVPLPRE---------------LAAA-TMAAPAVEVDVDVLAECRQPMSEVHS 173
                  ||.|...|.|.:|               |||| .:..|.            .|.|:
Mouse   138 ------TPPPTSPVALSKEDMIGCSFQSLTHSPGLAAAHHLTYPG------------HPTSQ--- 181

  Fly   174 EEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRP-CSALSERQEIKLVEEEIAAVLSGESEVLK 237
                  ..||.:|..:....|    |:.|..|..| .|:|.       :||:
Mouse   182 ------QAGHSSPSDSAVRVL----LHSPGRPSSPRFSSLD-------LEED------------- 216

  Fly   238 EHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKS----- 297
                                 |:|.:.|            :||||        .|..|:.
Mouse   217 ---------------------SEVFKML------------QENRQ--------GRAAPRQSSSFR 240

  Fly   298 --KQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPK 340
              :::||||.|....   ..|.|:...::.:|.::..   |||||
Mouse   241 LLQEALEAEERGGTP---AFVPSSLSSQASLPTSRAL---ATPPK 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	29/60 (48%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Pdlim2	NP_001240665.1	PDZ_signaling	9..80	CDD:238492	31/67 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..147		18/82 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..212		13/67 (19%)
		DUF4749	<198..252	CDD:406377	20/114 (18%)
		LIM_Mystique	283..335	CDD:188833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050