Protein Alignment Zasp67 and alp-1

DIOPT Version :10

• Sequence 1: NP_648358.2
• Gene: Zasp67 / 39148
• FlyBaseID: FBgn0036044
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: NP_001023371.1
• Gene: alp-1 / 177701
• WormBaseID: WBGene00001132
• Length: 1424
• Species: Caenorhabditis elegans
• Alignment Length: 802
• Identity: 149/802 - (18%)
• Similarity: 263/802 - (32%)
• Gaps: 208/802 - (25%)

  Fly     5 IKMCRFD-NVPWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAH 68
            ::|.|.| ..||||.:....  |..:.:|.|..||:||.||||..|::.|:.|  ...|..:...
 Worm     6 VRMARSDRRTPWGFGVTEAP--DGAVLIVNVIGGSLADRAGLRNGDVVDRLED--LDNLDINAVD 66

  Fly    69 RLIMGSGSVFYFGVYRENEEDAYECLKKFPTSE--GSLTKSPMPTISPSPTPSLSQLTETTNAR- 130
            ||::                .|:|.::...|.:  |:.|:...|.::.:..|...|.....|.:
 Worm    67 RLLV----------------TAHEKIELIVTRQPSGAATRIWRPEVTENTGPGQDQTPYRVNLQH 115

  Fly   131 ---TPEPEPFVPLPRELAAATMAAPAVEVDVDVL-AECRQPMSEVHSEEKRGDVNGHDAPGQADE 191
               |..|:.|          ..:|...|.|..|. .:...|:. ::|::...:.......|..|.
 Worm   116 SSDTRPPQGF----------NNSALPFETDQRVKHMQYNSPLG-IYSDKSAAEQYVQQTQGLGDN 169

  Fly   192 GGLPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEH-NVLGVNFYRIFPKP-- 253
            .|...    .....|.|....||  .::|::|:......|....|..| |..|:....:..:|
 Worm   170 SGARA----AAQRQDEPAYLRSE--TLRLLKEQEHGSAGGAGTTLSNHPNPSGLPVCFMCTRPIL 228

  Fly   254 ------------GVCMS----SDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLE 302
                        |.|:|    .:.||::.....:.|...|...      .||.:...|....::
 Worm   229 GVMARAAGKNLHGDCLSCATCGNSLRNVGHHFIEDKFYCDIHG------TQRKHGGRPGMDPNI- 286

  Fly   303 AERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEP 367
                        .|||:|....|: ..:.:|:.|..|   :.....|     |...|.|....:.
 Worm   287 ------------FVKSSPTAAQPV-HIQDSPRAAYHP---QVNTARP-----VSVSPAPSAGSKT 330

  Fly   368 LPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPI 432
            :.|....|..:.:       ..|.:...|......::......|      ...||.|....:..:
 Worm   331 VTTHYHTPKTQGI-------LSPGQRGVPTAAFGADLSKSVTYG------GGVGPGGTHYDSNRL 382

  Fly   433 TPVPVKSEEELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQID 497
            :|.|.:...:...:.|....|..:.|...:||                                :
 Worm   383 SPAPSQYSTQSRNQSQQHYQQHVVQAPPPVPS--------------------------------N 415

  Fly   498 ENSGNEEQVEEGVTTATNTINTAGETEDAGKDISISGSDNPPVGPCESNE----DRCDANDRE-- 556
            ....||:|.:..|....:::.:|.....:||    |....||.....:|.    |..||..:|
 Worm   416 PPPSNEQQSQSRVQNLPDSVRSAVSPRRSGK----SPRQWPPPAMPTTNRYWQIDPADALKKEKV 476

  Fly   557 ---------VAEISRSTD-DNRLAKDKKK---------DLDQEQKQQQQQQQEPLSEEQNFKKQK 602
                     :.|:.:|.: :.::.|:.||         ::.:||.||..::|...:|.:..||
 Worm   477 NYGEDLVALIKEVEQSKEKEPKVKKEPKKGTRGARRASNISKEQVQQAFEEQRKRTERKEIKK-- 539

  Fly   603 RHDVIEELEEHLVRKNNPR-RSKRAFGPLVPSSERPLVLP-----------GGRRWY-------- 647
                   ||:.:  |..|. :.:....|||..:.:||..|           .|..|.
 Worm   540 -------LEKEI--KPKPELKVEVPVEPLVVPTSKPLEEPCPEALPPPKINDGIHWTVIHSPVLR 595

  Fly   648 --RPKDAYNDEFIAETLSAQAEL--ITGSTLGVNFMKYQKPERKIDLNRSEVYKYLNPHLDRAPV 708
              .|....::..|.|:......:  .....:|::.....:|.|.    .|:|.:   ||.....:
 Worm   596 SPSPAKVTSEAAIPESNGVVKPIPSYASQPIGISKTSTPQPFRP----GSQVER---PHYSSVGL 653

  Fly   709 RGIEVRAPLVAAESDIRQSLQS 730
            :.:....||..:.....|.:||
 Worm   654 KDVHAPVPLPRSPQHSPQPVQS 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_ZASP52-like	4..84	CDD:467281	24/79 (30%)
		DUF4749	653..>699	CDD:464948	7/47 (15%)
alp-1	NP_001023371.1	PDZ_canonical	5..82	CDD:483948	26/95 (27%)
		ZM	137..162	CDD:128974	3/25 (12%)
		LIM_ALP_like	220..271	CDD:188746	8/50 (16%)
		PRK10263	<569..>834	CDD:236669	18/114 (16%)
		LIM1_Enigma_like_1	1251..1304	CDD:188839
		LIM	1312..1363	CDD:413332
		LIM3_Enigma_like_1	1371..1424	CDD:188845