DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Mpdz

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	756	Identity:	144/756 - (19%)
Similarity:	246/756 - (32%)	Gaps:	250/756 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IKMCRFDNVPWGFRLVGGADYDYPLT---------VVKVTEGSIADEAG-LRVEDIIVRINDTAA 59
            :::.|..:...|..:|||......|:         :..|.|.|.|.:.| |:..|.|:.::....
Mouse  1154 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDL 1218

  Fly    60 TPLTHDEAHRLIMGSGSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLS--- 121
            ...:|::|...|..:|:...|.|         :.:...|      .|||:|::..|..|..|
Mouse  1219 RDASHEQAVEAIRKAGNPVVFMV---------QSIINRP------RKSPLPSLPHSLYPKYSFSS 1268

  Fly   122 ------QLTETTNARTPEPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDV 180
                  .|..||:....:.|.....| .|.....::|:|..::.  ::|.||.:...||::
Mouse  1269 TNPFADSLQLTTDQAPSQSESETEKP-ALCNVPPSSPSVFSEMG--SDCAQPSATAVSEDE---- 1326

  Fly   181 NGHDAPGQADEGGLPVENLYLPDLPDRPCSALSERQEIKLVEEE--IAAVLSGESEVLKEHNVLG 243
                  .:.||.|...:|     :.:|..|...:...|:|.:.:  :...|:|.    |:...:.
Mouse  1327 ------DKEDEFGYSWKN-----IQERYGSLTGQLHVIELEKGQSGLGLSLAGN----KDRTRMS 1376

  Fly   244 VNFYRIFP-----KPGVCMSSDVLRSLNEEVTKTKLEKDKENRQWSTFLQ-RPNRPVPKSKQSLE 302
            |....|.|     :.|....:|.|..:|.::.     ..:.::..|:.:: .|:    |.|....
Mouse  1377 VFIVGIDPTGAAGRDGRLQIADELLEINGQIL-----YGRSHQNASSIIKCAPS----KVKIIFI 1432

  Fly   303 AERRAANAYKVT--IVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDE 365
            ....|.|...|.  |...:|...|..|:                                 .|:.
Mouse  1433 RNADAVNQMAVCPGIAADSPSSTSDSPQ---------------------------------NKEV 1464

  Fly   366 EPLPTDS----EVPNLEQLPETELPDEQPEKSDAPKEVCEPEVV--IQTEPGSPDGNEASDG--- 421
            ||..|.|    ::.:|..:.:.|||.:|.....|   :||.:.:  :..|..:..|..|.||
Mouse  1465 EPCSTTSASAADLSSLTDVYQLELPKDQGGLGIA---ICEEDTINGVMIESLTEHGGAAKDGRLK 1526

  Fly   422 --------------------------PAGATP-----------PAEPITPVPVKSEEELALERQL 449
                                      .|.||.           ||.|.:.|.|..|.:
Mouse  1527 PGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAENPACPAVPSSAVTVSGERK------- 1584

  Fly   450 ADVQRQLAA----LSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSGNEEQVEEGV 510
             |..:..|.    |..:|||.:|:..||........|.|               .|.|..:|
Mouse  1585 -DNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPATCPII---------------PGCETTIE--- 1630

  Fly   511 TTATNTINTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRL-AKDKK 574
                   .:.|:|   |..:||.|..:..:|....:         ||.|...:..|.|| |.|:
Mouse  1631 -------ISKGQT---GLGLSIVGGSDTLLGAIIIH---------EVYEEGAACKDGRLWAGDQ- 1675

  Fly   575 KDLDQEQKQQQQQQQEPLSEEQNFKKQK-RHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPL 638
                             :.|......:| .||     |...|.:..|:|.:             |
Mouse  1676 -----------------ILEVNGIDLRKATHD-----EAINVLRQTPQRVR-------------L 1705

  Fly   639 VLPGGRRWYRPKDAYNDEFIAETLSAQAELITGSTLGVNFM 679
            .|      ||.:..|.:|.:.:|.:.:.:...|..||::.:
Mouse  1706 TL------YRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIV 1740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	17/79 (22%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	6/27 (22%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372
		PDZ	375..464	CDD:214570
		PDZ_signaling	553..622	CDD:238492
		PDZ_signaling	694..777	CDD:238492
		PDZ_signaling	994..1064	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144
		PDZ_signaling	1151..1242	CDD:238492	20/96 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313		7/37 (19%)
		PDZ	1349..1434	CDD:214570	16/97 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473		8/56 (14%)
		PDZ_signaling	1483..1563	CDD:238492	15/82 (18%)
		MPDZ_u10	1564..1625	CDD:293272	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611		12/47 (26%)
		PDZ	1626..1710	CDD:214570	28/147 (19%)
		PDZ_signaling	1722..1802	CDD:238492	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848
		PDZ_signaling	1859..1944	CDD:238492
		PDZ_signaling	1985..2068	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810