DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Grip2

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	672	Identity:	126/672 - (18%)
Similarity:	214/672 - (31%)	Gaps:	251/672 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDYP-LTVVKVTEGSIADEAG-LRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            |..|..|:..:.| :|:.::...|:.|.:| |...|.|:.|:.|:....:..||.:|:   .||
  Rat   265 GISLTTGSHRNKPAITIDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLL---ASV- 325

  Fly    79 YFGVYRENEEDAYECLKKFPTSEGSL-----------------------TKSPMPTISPSPT--- 117
                   .|:...|.|.. |.|...|                       ..||.|:...:||
  Rat   326 -------TEKVRLEILPA-PQSRRPLKPPEAVRIQRSEQLHHWDPCVPSCHSPRPSHCRAPTWAP 382

  Fly   118 --PSLSQLTETTNARTPEPEPFVP------LPR-----------------------ELAAATM-- 149
              ...|:...:|...:|...|..|      |||                       .||::|:
  Rat   383 GGQDQSRSVSSTPFSSPTMNPAFPCANASTLPRGPMSPRTTAGRRRQRRKEHRSSLSLASSTVGP 447

  Fly   150 AAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGL-PVENLYLPDL-----PDRP 208
            ....|..:...:..|..|:|..               |...:||: ..|.|..|.|     ||.|
  Rat   448 GGQIVHTETTEVVLCGDPLSGF---------------GLQLQGGIFATETLSSPPLVRFIEPDSP 497

  Fly   209 CSALSERQEIKLVEEEIAAV--LSGESEVLKEHN------------VLGVNF------------Y 247
                :||..:..|.:.:.|:  ::.|...::|.|            ||.:.|            :
  Rat   498 ----AERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAESVIPSSGTF 558

  Fly   248 RI-FPKP-----GVCMSS-----------------------------DVLRSLN----------- 266
            .: .||.     |:.:||                             |.|.:::
  Rat   559 HVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDHCPMEY 623

  Fly   267 --------EEVTKTKLEKDKENR---------QWSTFLQRPNRPVPKSKQSLE------------ 302
                    |::.|.|:.||::|.         .::..|:|...|:..:....|
  Rat   624 AVQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPFDPIIISGLT 688

  Fly   303 ----AERRAA--NAYKVTIVKSAPREKSPMPEAKPAPKEA--TPPKEVEKKEEEP-VPEEVVEPE 358
                |||..|  ...::..:.|...:..|:.||....:.|  |...:::|:.:.| :|.:.....
  Rat   689 KRGLAERTGAIHVGDRILAINSVSLKGRPLSEAIHLLQVAGETVTLKIKKQLDRPLLPRQSGSLS 753

  Fly   359 PEPEKDEEP--------LPT--DSEVPNLEQLPET--------------ELPDEQPEKSDAPKEV 399
            ...:.||:|        |.|  ...||:::...|:              ....:...:|..|:|.
  Rat   754 EASDVDEDPPEALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFGGSGSYTPQVAVRSVTPQEW 818

  Fly   400 CEPEVVIQTEPGSPDGNEASDGPAGATPPAE-------PITPVPVKSEEE---LALERQLADVQ- 453
            ....:.....|..|.....:.||...:.|.|       |::|.|..:.||   ..|...|.|::
  Rat   819 RSSRLKSSPPPLEPRRTSYTPGPTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLES 883

  Fly   454 -------RQLAALSSLPSTIQS 468
                   |:|.| |.:..|:||
  Rat   884 CGQSELLRELEA-SIMTGTVQS 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	16/60 (27%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492
		PDZ_signaling	251..334	CDD:238492	20/79 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		14/78 (18%)
		PDZ_signaling	456..544	CDD:238492	22/106 (21%)
		PDZ_signaling	557..640	CDD:238492	10/82 (12%)
		PDZ_signaling	657..737	CDD:238492	14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863		12/76 (16%)
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810