DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Il16

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001347016.1	Gene:	Il16 / 16170	MGIID:	1270855	Length:	1424	Species:	Mus musculus

Alignment Length:	754	Identity:	155/754 - (20%)
Similarity:	242/754 - (32%)	Gaps:	235/754 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDY-PLTV-VK--VTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            ||.:|||.|..| |:.: ||  ...|:.|.:..|:..|.|:.:|..:...|||.:|
Mouse   327 GFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA--------- 382

  Fly    77 VFYFGVYRENEEDAYECLKKF-PTSEGSLTKSPMPTISPSP------TPSLSQLTETTNARTPEP 134
                             |:|| ...:|.||.:....::..|      :|.|.:...::.....:.
Mouse   383 -----------------LQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDS 430

  Fly   135 EPFVPLPRELAAATMAAPAVEVDVDV-----------LAECRQPMSE------VHSEEKRGDVNG 182
            .|| .|....:.|:.|.|...:.|:|           :..|..|..:      ||:.
Mouse   431 SPF-SLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTL-------- 486

  Fly   183 HDAPGQ----------ADEGGLPVENLYLPDLPDRP--CSALSERQEIKLVEEEIAAVLS----G 231
              :||.          .||         :.::.|.|  |..|:          |:..:||    |
Mouse   487 --SPGSVAHLDGRLRCGDE---------IVEINDSPVHCLTLN----------EVYTILSHCDPG 530

  Fly   232 ESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQW---------STFL 287
            ...::...:          |.|.| ....:..::.:.|...|..||:  .||         |::.
Mouse   531 PVPIIVSRH----------PDPQV-SEQQLKEAVAQAVEGVKFGKDR--HQWSLEGVKRLESSWH 582

  Fly   288 QRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPRE-KSPMPEAKPAPKEATP-PKEVEKKEEEP- 349
            .||.....:.|.|....||   |.|:.:..|:... .|..|...|....|.| |.|.|.....|
Mouse   583 GRPTLEKEREKHSAPPHRR---AQKIMVRSSSDSSYMSGSPGGSPCSAGAEPQPSEREGSTHSPS 644

  Fly   350 -VPEEVVEPEP----EPEKDEEPLPTDSEVPN------------LEQLPETELPDEQPEK----- 392
             .|.|..||.|    .|:::..|||...|..:            |.:.|.:..|...|.|
Mouse   645 LSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRLKKSFEILVRKPTSSKPKPPPRKYFKND 709

  Fly   393 SDAPKEVCEPEVVIQTEPG-------SPDGNE-----ASDGPAGATPPAEPITPVPVKSEEELAL 445
            |:..|::.|.|.|  |:|.       |.:..|     ..:..||..|......|.|..|.:..:.
Mouse   710 SEPQKKLEEKEKV--TDPSGHTLPTCSQETRELLPLLLQEDTAGRAPCTAACCPGPAASTQTSSS 772

  Fly   446 ----ERQLAD------------VQRQLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLP 494
                .|:.|.            ::||.....|...|.:.....::..:.:|...|..:.......
Mouse   773 TEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTPL 837

  Fly   495 QIDENSGNEEQVE---EGVTTATNTINTA--------GETEDAGKDISISGSDNPPVGP------ 542
            |.:.:.|.|:..:   ||..:..:..|.|        |.|...|          |||.|
Mouse   838 QPNTSLGEEDGTQGCPEGGLSKMDAANGAPRVYKSADGSTVKKG----------PPVAPKPAWFR 892

  Fly   543 --CESNEDRCDANDR--EVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKR 603
              .:...:|.....|  |||...:.|..:|       |....|.|.....::.:|..:||...:.
Mouse   893 QSLKGLRNRAPDPRRPPEVASAIQPTPVSR-------DPPGPQPQASSSIRQRISSFENFGSSQL 950

  Fly   604 HDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPLVLPG 642
            .|               |..:|.  .|.|||......||
Mouse   951 PD---------------RGVQRL--SLQPSSGETTKFPG 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	20/62 (32%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Il16	NP_001347016.1	PDZ_signaling	316..391	CDD:238492	23/89 (26%)
		PDZ_signaling	454..536	CDD:238492	17/110 (15%)
		Atrophin-1	<620..931	CDD:331285	69/329 (21%)
		PDZ_signaling	1206..1283	CDD:238492
		PDZ_signaling	1328..1409	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900