DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and FRMPD2

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	377	Identity:	77/377 - (20%)
Similarity:	136/377 - (36%)	Gaps:	80/377 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDYPLTVVKVTE----GSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            ||.:.||.:...|...:.|..    |..|.|..:...|.:::::......|||.:|.:.:.|.|.
Human   961 GFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ 1025

  Fly    77 VFYFGVYRENEEDAYECLKKFPTSEGSL----TKSPMPTISPSPTPSLSQLTETTNARTPEPEPF 137
            |....:.|.......:|    |::..|:    |...:.|..|....|...:|:       .|:..
Human  1026 VARLVLERRVPRSTQQC----PSANDSMGDERTAVSLVTALPGRPSSCVSVTD-------GPKFE 1079

  Fly   138 VPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADE--GGLPVENLY 200
            |.|.:.  |..:....|:::.:..:..:..:..:    ||      ..|||..|  |.:...::.
Human  1080 VKLKKN--ANGLGFSFVQMEKESCSHLKSDLVRI----KR------LFPGQPAEENGAIAAGDII 1132

  Fly   201 LPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSL 265
            |         |::.|....|:.:|:..:|.|..:        .|......|.||      .|..|
Human  1133 L---------AVNGRSTEGLIFQEVLHLLRGAPQ--------EVTLLLCRPPPG------ALPEL 1174

  Fly   266 NEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPE-A 329
            .:|....:|..|||..: :|.......|:      |:.|    ::::.:....|.......|| :
Human  1175 EQEWQTPELSADKEFTR-ATCTDSCTSPI------LDQE----DSWRDSASPDAGEGLGLRPESS 1228

  Fly   330 KPAPKEATPPKEVEKKEEEPVPEEVV-EPEPEP-------EKDEEPLPTDSE 373
            :.|.:||    :..:..|.|....:. .||..|       |:||..|.|..|
Human  1229 QKAIREA----QWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLE 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	15/62 (24%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880
		PDZ	947..1034	CDD:214570	17/72 (24%)
		PDZ	1078..1167	CDD:214570	19/117 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		4/27 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900