DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zasp67 and Patj

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_038965114.1	Gene:	Patj / 140581	RGDID:	1565362	Length:	1858	Species:	Rattus norvegicus

Alignment Length:	816	Identity:	171/816 - (20%)
Similarity:	267/816 - (32%)	Gaps:	274/816 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DIKMCRFDNVPWGFRLVGGADYDYPLTVVKVTEGSIADEAG-LRVEDIIVRINDTAATPLTHDEA 67
            |:::.. |....||.:|||....  :.|..:..|.:||..| |:..|.|::|..|....:|.::.
  Rat   248 DVELIN-DGSGLGFGIVGGKSSG--VVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMTSEQV 309

  Fly    68 HRLIMGSGSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTP 132
            .:::...|:.....|.|:            |..|.::| .|.|...|...|.::  |.|..:
  Rat   310 AQVLRNCGNSVRMLVARD------------PVGEIAVT-PPTPASLPVALPVVA--TRTLGS--- 356

  Fly   133 EPEPFVPLPRELAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVE 197
            :..||.....||......:..:.:...|                     |...||:|  .|:.|:
  Rat   357 DSSPFETYNVELVKKDGQSLGIRIVGYV---------------------GTAHPGEA--SGIYVK 398

  Fly   198 NLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVL 262
            ::.       |.||.....:|: |.::|.|             |.|||......:..|    :||
  Rat   399 SII-------PGSAAYHNGQIQ-VNDKIVA-------------VDGVNIQGFANQDVV----EVL 438

  Fly   263 RSLNEEVTKTKLEKDKENRQWSTFLQRPNRPV---------------PKSKQSLEAE---RRAAN 309
            |:..:.|..| |.:.|.:...|.|.|..:|..               |::...:|||   .|..|
  Rat   439 RNAGQVVHLT-LVRRKTSLSASPFEQPSSREAVAEPPEVPELTGSLKPETNSRMEAEEIGERLDN 502

  Fly   310 AYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEEPV-PE-EV--------VEPEPEPEKD 364
            ..|.|:      :....|:..|......|..|::.:.|..: |: ||        :..:.|.:|.
  Rat   503 LRKDTV------QALEKPDVYPEDIPGCPENELKSRWENLLGPDYEVMVATLDTQIADDEELQKY 561

  Fly   365 EEPLP---------TDS----------------EVPNLEQLPETELPD---------EQPEKSDA 395
            .:.||         .||                :..||.| ||.||.:         .:.|....
  Rat   562 SKLLPIHTLRLGMEVDSFDGHHYISSIAPGGPVDTLNLLQ-PEDELLEVNGVQLYGKSRREAVSF 625

  Fly   396 PKEVCEPEVVIQTEPGSPDGNEAS-DGPAGATP---PAEPITPVPVKSEE---ELALER------ 447
            .|||..|..::.......|  ||| |.|....|   .||....|.|.:|:   ||||..
  Rat   626 LKEVPPPFTLVCCRRLFDD--EASVDEPRTVEPSLLEAEVDRSVDVSTEDDDGELALWSPEVKTV 688

  Fly   448 -----------QLADVQRQLAALSSLPSTIQSTLDAVTKQLADLLPTIKLQQQEKQLPQIDENSG 501
                       .:.|.|..|..:.|:........|.|.::..:|||..:|.            |.
  Rat   689 ELVKDCKGLGFSILDYQDPLDPMRSVIVIRSLVADGVAERSGELLPGDRLV------------SV 741

  Fly   502 NEEQVEEGVTTATNTINTAGETEDAGKDISISGSDNPP----VGPCESNEDRCDANDREVAEISR 562
            ||..::..         |..|..:..|.:       ||    :|.|
  Rat   742 NEFSLDNA---------TLAEAVEVLKAV-------PPGVVHLGIC------------------- 771

  Fly   563 STDDNRLAKDKKKDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAF 627
                                       :||.||:.          ||.|||.:..:|........
  Rat   772 ---------------------------KPLVEEEK----------EEKEEHFIFHSNNNGDNSES 799

  Fly   628 GPLVPSSERPLVL--PGGRRWYRPKDAYNDEFIAETLSAQAELITGSTLGVNFMKYQKPERKIDL 690
            ...|......|:|  |.|         :.||...|.|..:..|..|.:|     ::|:.:.....
  Rat   800 PETVHEIHSSLILEAPQG---------FRDEPYLEELVDEPFLDLGKSL-----QFQQKDMDSSS 850

  Fly   691 NRSEVYKYLNPHLDRAPVRGIEVRAPLVAAESDIRQ 726
            ...|::::|:|.|:|   || |.|..||..|.:|.|
  Rat   851 EAWEMHEFLSPRLER---RG-EEREMLVDEEYEIYQ 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	18/71 (25%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	9/45 (20%)
Patj	XP_038965114.1	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492	19/79 (24%)
		PDZ_signaling	366..450	CDD:238492	26/132 (20%)
		CtpA	<391..>511	CDD:223864	34/153 (22%)
		PDZ_signaling	572..636	CDD:238492	14/64 (22%)
		PDZ	684..773	CDD:214570	20/162 (12%)
		PDZ_signaling	1074..1165	CDD:238492
		PDZ	1244..1329	CDD:214570
		PDZ	1471..1578	CDD:214570
		PDZ_signaling	1590..1670	CDD:238492
		PDZ_signaling	1731..1816	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900