DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Patj

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	827	Identity:	164/827 - (19%)
Similarity:	258/827 - (31%)	Gaps:	321/827 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDYPLTVVKVTEGSIADEAG-LRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVFY 79
            ||.:|||....  :.|..:..|.:||..| |:..|.|::|..|....:|.::..:::...|:...
Mouse   259 GFGIVGGKSSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVR 321

  Fly    80 FGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPREL 144
            ..|.|:            |..|.::|         .|||                   |.||
Mouse   322 MLVARD------------PVGEIAVT---------PPTP-------------------VSLP--- 343

  Fly   145 AAATMAAPAV---EVDVDVLAECRQPMSEVHSEE---KRGDVNG----------HDAPGQADEGG 193
                :|.|||   .:|.|     |.|. |.:|.|   |.|...|          |  ||:|  .|
Mouse   344 ----VALPAVATRTLDSD-----RSPF-ETYSVELVKKDGQSLGIRIVGYVGTAH--PGEA--SG 394

  Fly   194 LPVENLYLPDLPDRPCSALSERQEIKLVEEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMS 258
            :.|:::.       |.||.....:|: |.::|.|             |.|||......:..|
Mouse   395 IYVKSII-------PGSAAYHNGQIQ-VNDKIVA-------------VDGVNIQGFANQDVV--- 435

  Fly   259 SDVLRSLNEEVTKTKLEKDKENRQWSTFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREK 323
             :|||:..:.|..|.:.:                     |.||.|
Mouse   436 -EVLRNAGQVVHLTLVRR---------------------KTSLSA-------------------- 458

  Fly   324 SPMPEAKPAPKEATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVPNLEQ--LPETELP 386
            ||...:......|.|||         |||....|:||.....|.......:.||:.  :...|.|
Mouse   459 SPFEHSSSRETVAEPPK---------VPERAGSPKPEANLSVEAEEIGERLDNLKNNTVQALEKP 514

  Fly   387 DEQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGATPPAEPITPVPVKSEEELALERQLAD 451
            |..|||                .||||:....|.......|..|.:.         ..|:.|:||
Mouse   515 DVYPEK----------------VPGSPENELKSRWENLLGPDYEVMV---------ATLDAQIAD 554

  Fly   452 VQRQLAALSSLP-STIQSTLDAVT----KQLADLLP-----TIKLQQQEKQLPQI---------- 496
            .:........|| .|::..::..:    ..::.:.|     |:.|.|.|.:|.::
Mouse   555 DEELQKYSKLLPIHTLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQPEDELLEVNGMQLYGKSR 619

  Fly   497 ------------------------DENSGNEEQVEEGV---TTATNTINTAGETEDAG------- 527
                                    ||.|.:|.:..|..   ....::::...|.:|.|
Mouse   620 REAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPALLEAEVDHSVDVNIEDDDDGELALWSP 684

  Fly   528 -----------KDISISGSD-NPPVGPCES--------------NEDRCDANDREVAEISRSTDD 566
                       |.:..|..| ..|:.|..|              ........||.|:....|.|:
Mouse   685 EVKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGELLPGDRLVSVNEFSLDN 749

  Fly   567 NRLAKDKK---------------KDLDQEQKQQQQQQQEPLSEEQNFKKQKRHDVIEELEEHLVR 616
            ..||:..:               |.|.:::|:::..    |....|....:..|.:.|:...|:
Mouse   750 ATLAEAVEVLKAVPPGVVHLGICKPLVEDEKEERFS----LHSNNNGDSSEPADAVHEIHSSLI- 809

  Fly   617 KNNPRRSKRAFGPLVPSSERPLVLPGGRRWYRPKDAYNDEFIAETLSAQAELITGSTLGVNFMKY 681
                                 |..|.|         :.||...|.|..:..|..|.:|
Mouse   810 ---------------------LEAPQG---------FRDEPYLEELVDEPFLDLGKSL------- 837

  Fly   682 QKPERKIDLNRS--EVYKYLNPHLDRAPVRGIEVRAPLVAAESDIRQ 726
            |..::.:|.:..  |::::|:|.||.   || |.|..||..|.::.|
Mouse   838 QFQQKDVDSSSEAWEMHEFLSPPLDG---RG-EEREMLVDEEYELYQ 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	16/59 (27%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	10/47 (21%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492
		PDZ_signaling	248..325	CDD:238492	17/67 (25%)
		PDZ_signaling	363..450	CDD:238492	28/115 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		14/60 (23%)
		PDZ_signaling	572..636	CDD:238492	6/63 (10%)
		PDZ	685..774	CDD:214570	13/88 (15%)
		PDZ_signaling	1072..1163	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219
		PDZ	1242..1327	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900