DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and Il16

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_006229550.1	Gene:	Il16 / 116996	RGDID:	1583872	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	841	Identity:	174/841 - (20%)
Similarity:	266/841 - (31%)	Gaps:	289/841 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GFRLVGGADYDY-PLTV-VK--VTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGS 76
            ||.:|||.|..| |:.: ||  ...|:.|.:..|:..|.|:.:|..:...|||.:|
  Rat   327 GFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESIAGLTHQDA--------- 382

  Fly    77 VFYFGVYRENEEDAYECLKKF-PTSEGSLTKSPMPTISPSP------TPSLSQLTETTNARTPEP 134
                             |:|| ...:|.||.:....::..|      :|.|.:...::.....:.
  Rat   383 -----------------LQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDS 430

  Fly   135 EPFVPLPRELAAATMAAPAVEVDVDV-----------LAECR---------------QPMSEVHS 173
            .|| .|....:.|:.|.|...:.|:|           :..|.               .|.|..|.
  Rat   431 SPF-SLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGVFIHTLSPGSVAHL 494

  Fly   174 EEKR--GD--VNGHDAP-------------GQADEGGLPVENLYLPDLPDRPCSALSERQEIKLV 221
            :.:.  ||  |..:|:|             ...|.|.:|:.....||      ..:||:|    :
  Rat   495 DGRLRCGDEIVEINDSPVHCMTLNEVYTILSHCDPGPVPIIVSRHPD------PQVSEQQ----L 549

  Fly   222 EEEIAAVLSGESEVLKEHNVLGVNFYRIFPKPGVCMSSDVLRSLNEEVTKTKLEKDKENRQW--- 283
            :|.:|..            |.||.|                              .||..||
  Rat   550 KEAVAQA------------VEGVKF------------------------------GKERHQWSLE 572

  Fly   284 ------STFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPRE-KSPMPEAKPA-------PK 334
                  |::..||.....:.|.|....||   |.|:.:..|:... .|..|...|.       |.
  Rat   573 GVKRLESSWHGRPTLEKEREKHSAPPHRR---AQKIMVRSSSDSSYMSGSPGGSPCSAGAELQPS 634

  Fly   335 E--------ATPPKEVEKKEEEPVPEEVVEPEPEPEKDEEPLPTDSEVP--------NLEQLPET 383
            |        :.||.|    |:||.|.....|..|.....|.|..||..|        .|.:.|.:
  Rat   635 EGEGSTHSPSLPPGE----EQEPCPGVPSRPHQESPPLSESLERDSHPPLKLKNSFEILVRKPTS 695

  Fly   384 ELPDEQPEK-----SDAPKEVCEPEVVIQTEPG-------SPDGNE------------------- 417
            ..|...|.|     |:..|::.|.|.|  |:|.       |.:..|
  Rat   696 TKPKPPPRKYFKNDSEPQKKLEEKEKV--TDPSGHTLPTCSQETRELLPLLLQEDTAGRTLCTAA 758

  Fly   418 ASDGPAGATPPAEPITPVPVK--SEEELALERQLADVQRQLAALSSLPSTIQSTLDAVTKQLADL 480
            ...|||.:|..:......|.:  |.|..|...:...::||.....|..||.:.....::..:.:|
  Rat   759 CCPGPAASTQTSSSTEGEPRRSASPETPASPGKHPLLKRQARMDYSFDSTTEDPWVRISDCIKNL 823

  Fly   481 LPTIKLQQQEKQLP-QIDENSGNEEQVE---EGVTTATNTINTA--------GETEDAGKDISIS 533
            ...| :.:....:| |.:.:.|.|:..:   ||..:..:|.|.|        |.|...|
  Rat   824 FSPI-MSENHSHMPLQPNASLGEEDGTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKG------ 881

  Fly   534 GSDNPPVGP--------CESNEDRCDANDR--EVAEISRSTDDNRLAKDKKKDLDQEQKQQQQQQ 588
                |||.|        .:...:|.....|  |||...::|..:|.|...:........:|:
  Rat   882 ----PPVAPKPAWFRQSLKGLRNRVPETRRAPEVASAIQTTPVSRDASGPQSQASSSSIRQR--- 939

  Fly   589 QEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAFGPLVPSSERPLVLPGGRRWYRPKDAY 653
               :|..:||...:..|               |..:|.  .|.|:|.....|||.:
  Rat   940 ---ISSFENFGSSQLPD---------------RGVQRL--SLQPTSGETTRLPGKQ--------- 975

  Fly   654 NDEFIAETLSAQAELITGSTLGVNFMKYQ----KPERKIDLNRSEVYKYLNPHLDRAPVRG 710
             ||.....|.||...:|.        |::    :|......|.|||.   :|.:..:|..|
  Rat   976 -DEGRFSGLPAQGTKVTA--------KHRQTEVEPPSTTFPNSSEVG---DPDMSESPPPG 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	20/62 (32%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	12/49 (24%)
Il16	XP_006229550.1	PDZ_signaling	316..391	CDD:238492	23/89 (26%)
		PDZ_signaling	454..536	CDD:238492	13/81 (16%)
		PDZ_signaling	1207..1284	CDD:238492
		PDZ	1329..1413	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900