DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and PDLIM5

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001243355.2	Gene:	PDLIM5 / 10611	HGNCID:	17468	Length:	625	Species:	Homo sapiens

Alignment Length:	523	Identity:	106/523 - (20%)
Similarity:	163/523 - (31%)	Gaps:	196/523 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PWGFRLVGGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDEAHRLIMGSGSVF 78
            ||||||.||.|::.|||:..:.:|..|.:|.:|:.|:::.|:...|..:||.||...|.|
Human    13 PWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKIKG----- 72

  Fly    79 YFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTPEPEPFVPLPRE 143
                          |                       |.||:...:..:| .|:||| ||:.:
Human    73 --------------C-----------------------TGSLNMTLQRASA-APKPEP-VPVQK- 97

  Fly   144 LAAATMAAPAVEVDVDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGLPVENLYLPDLPDRP 208
                    |.|   ..|.:|..|.::|       |...|.....:...|.:|         |.||
Human    98 --------PTV---TSVCSETSQELAE-------GQRRGSQGDSKQQNGKIP---------PKRP 135

  Fly   209 --------------CSALSERQEIKLVEE----------------EIAAVLSGESEVLKE---HN 240
                          ....|:..:.:|:|:                .|.|.::| :|.|||   .|
Human   136 PRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITG-TEHLKESEADN 199

  Fly   241 VLGVNF---YRIFPKPG---------VCMSSDVLRSLNEEVTKTKLEKDKEN--------RQWST 285
            .....|   ....||.|         :.:.|.|........|.:.|.....|        |.:||
Human   200 TKKAKFDSALEDLPKSGPHPPATPQVLTIGSQVATLSKVATTYSSLSSSTGNVEDSFEGFRNFST 264

  Fly   286 F---------------------------LQRPNR-----------PV--PKSKQSLEAERRAANA 310
            |                           |..|.|           ||  |.:...|::.|::..:
Human   265 FSSPARYSAAVLSSAAATVSAVIATKTRLYTPERYHSLLDALCISPVSKPLAFSYLQSSRKSTGS 329

  Fly   311 YKVTIVKSAPREKSP-----------MPEAKPAPKEATP--PKEVEKKEEEPVPEEVVEPEPEPE 362
            ..|....:: :|.||           |||:..:|....|  .........:||....|...|..:
Human   330 IHVKKTSNS-QEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQ 393

  Fly   363 KDEEPLPTDSEVPNLEQLPETELPDEQPEKSDAPKEVCEPEVVIQTEPGSPDG--NEASDGPAGA 425
            :..:.:|:...:.|......:..|..              ..:.||:|...|.  ..|...|||.
Human   394 RPNQGVPSTGRISNSATYSGSVAPAN--------------SALGQTQPSDQDTLVQRAEHIPAGK 444

  Fly   426 TPP 428
            ..|
Human   445 RTP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	25/60 (42%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
PDLIM5	NP_001243355.2	PDZ_signaling	10..82	CDD:238492	29/110 (26%)
		DUF4749	105..201	CDD:406377	21/112 (19%)
		LIM1_ENH	449..500	CDD:188837
		LIM	508..559	CDD:413332
		LIM3_ENH	567..621	CDD:188843
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010