Protein Alignment Zasp67 and USH1C

DIOPT Version :9

• Sequence 1: NP_648358.2
• Gene: Zasp67 / 39148
• FlyBaseID: FBgn0036044
• Length: 730
• Species: Drosophila melanogaster
• Sequence 2: XP_016872564.1
• Gene: USH1C / 10083
• HGNCID: 12597
• Length: 956
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 135/622 - (21%)
• Similarity: 201/622 - (32%)
• Gaps: 235/622 - (37%)

  Fly     5 IKMCRFDNV-PWGFRLV--GGADYDYPLTVVKVTEGSIADEAGLRVEDIIVRINDTAATPLTHDE 66
            :|..|.|.: |.|..|.  ||.::...|.:..:.:|..||..||:|.|.|||||..:.:..||:|
Human    85 LKEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEE 149

  Fly    67 AHRLIMG----SGSVFYFGVY----------------------------------RENEEDAYEC 93
            ...||..    |..|.:.|:.                                  |||:|.
Human   150 VINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNRENKEK---- 210

  Fly    94 LKKFPTSEG------SLTKSPMPT----ISPSPTPSLS---------QLTET-----TNARTPEP 134
             |.|.:..|      |::..|:..    ||.....|||         |:.|.     :|....|.
Human   211 -KVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEA 274

  Fly   135 EPFVPLPRELAAATMAAPAVEV---DVDVLAECRQPMSEVHSEE----KRGDVNGHDAPGQADEG 192
            ...:...|.|..:.:||...|:   |.:.|||.||  .|:..:|    ||
Human   275 VNVLKSSRSLTISIVAAAGRELFMTDRERLAEARQ--RELQRQELLMQKR--------------- 322

  Fly   193 GLPVENLYLPDLPDRPCSALSERQEI----------KLVEE------EIAAVLSGESEVLKE-HN 240
             |.:|:..:          |.|:||:          |..||      |:..::..|.:..|: ..
Human   323 -LAMESNKI----------LQEQQEMERQRRKEIAQKAAEENERYRKEMEQIVEEEEKFKKQWEE 376

  Fly   241 VLGVNFYRIFPKPGVCMSSDVLRSLNEEV----------------------TKTKLEKDKENRQW 283
            ..|.....:.||           ::..||                      |..|..|||:..::
Human   377 DWGSKEQLLLPK-----------TITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKGKDKKKAKY 430

  Fly   284 STFLQRPNRPVPKSKQSLEAERRAANAYKVTIVKSAPREKSPMPEAKPAPKEATPPKEVEKKEEE 348
            .:.     :.:.|:|:.||.|::   .||         ||..|.|.:...|.....:||.:.|.|
Human   431 GSL-----QDLRKNKKELEFEQK---LYK---------EKEEMLEKEKQLKINRLAQEVSETERE 478

  Fly   349 PVPE---------------------------EVVEPEPEPEKDEEPLPTDSEVPNLEQ------L 380
            .:.|                           |:....|.|.....||     .|.|.:      |
Human   479 DLEESEKIQYWVERLCQTRLEQISSADNEISEMTTGPPPPPPSVSPL-----APPLRRFAGGLHL 538

  Fly   381 PETELPD-------------------EQPEKSDAPKEVCEPEVVIQTEPGSPDGNEASDGPAGAT 426
            ..|:|.|                   ..|..|:.|.:|..|.|:    |.|...:.:|......|
Human   539 HTTDLDDIPLDMFYYPPKTPSALPVMPHPPPSNPPHKVPAPPVL----PLSGHVSASSSPWVQRT 599

  Fly   427 PPAEPITPVPVKSEEELALERQLADVQRQLAALSSLP 463
            ||..||.|.|....::|...|.|.....:  |||:.|
Human   600 PPPIPIPPPPSVPTQDLTPTRPLPSALEE--ALSNHP 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	26/76 (34%)
		DUF4749	653..>699	CDD:292558
USH1C	XP_016872564.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900