DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zasp67 and LIMS4

DIOPT Version :9

Sequence 1:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001358269.1	Gene:	LIMS4 / 100288695	HGNCID:	39941	Length:	398	Species:	Homo sapiens

Alignment Length:	266	Identity:	48/266 - (18%)
Similarity:	70/266 - (26%)	Gaps:	128/266 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   496 IDENSGNEEQVEEGVTTATNTINTAGETEDAGKDISISGSDNPPVGPCESNEDRCDANDREVAEI 560
            |.||       ||....|.||::.|..|||                            :|.|:::
Human    12 IPEN-------EEIPRAALNTVHEANGTED----------------------------ERAVSKL 41

  Fly   561 SRSTDDNRLAKD----------------------------------KKKDLDQEQ----KQQQQQ 587
            .|...|.::.|:                                  ...:|..||    .|..||
Human    42 QRRHSDVKVYKEFCDFYAKFNMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQ 106

  Fly   588 QQEPLSEEQNFKKQKRHD-------------------VIEELE---------------------- 611
            ..|.|..|...:|...||                   ||:.:.
Human   107 FPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGF 171

  Fly   612 -----EHLVRKNNPRRSKRAFGPLVPS------SERPLVLPGGRRWYRPKDAYNDEFIAETLSAQ 665
                 .||.|..:.|...|..|..:..      .|:||:.....  |.| |.:|.....:.|:|.
Human   172 VKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDP--YHP-DHFNCANCGKDLTAD 233

  Fly   666 AELITG 671
            |:.:.|
Human   234 AQELKG 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558	5/19 (26%)
LIMS4	NP_001358269.1	LIM1_PINCH	72..130	CDD:188717	12/57 (21%)
		LIM2_PINCH	133..184	CDD:188718	5/50 (10%)
		LIM3_PINCH	197..247	CDD:188719	11/46 (24%)
		LIM4_PINCH	253..306	CDD:188720
		LIM5_PINCH	314..367	CDD:188721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930