Protein Alignment Ae2 and SLC4A8

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_011537312.1
• Gene: SLC4A8 / 9498
• HGNCID: 11034
• Length: 1111
• Species: Homo sapiens
• Alignment Length: 1118
• Identity: 369/1118 - (33%)
• Similarity: 572/1118 - (51%)
• Gaps: 194/1118 - (17%)

  Fly   210 ELRSHRS--------DDPRALRRHKIHHSSIKLR------------------ELPQITISPFTNK 248
            ||..||:        ...::.|.|:.|....:.|                  :.|...:......
Human    41 ELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGRGKGASQGEEGLEALAHDTPSQRVQFILGT 105

  Fly   249 KPEVDHSPHEIFVQLDEL-TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLR 312
            :.:.:|.|||:|.:|||: ...|||.||||||||:|:|||||:|.:||.||:||:||.|||..||
Human   106 EEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELR 170

  Fly   313 RCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDIND--KPSVMRSLLLRHRHVNE--HQGVLP 373
            .||..|.||||::...:..::..:::|..:..  |:||  :..|..:||.:|.|.||  ...::|
Human   171 SCLINGTVLLDMHANSIEEISDLILDQQELSS--DLNDSMRVKVREALLKKHHHQNEKKRNNLIP 233

  Fly   374 FTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAA 438
            ..:         .|..:|         :.|..|..:.|..:::. ..|.|.|
Human   234 IVR---------SFAEVG---------KKQSDPHLMDKHGQTVS-PQSVPTT------------- 266

  Fly   439 AAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDT 503
                           ||              |:..........:|:       |:.||.
Human   267 ---------------NL--------------EVKNGVNCEHSPVDL-------SKVDLH------ 289

  Fly   504 ILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYH 568
            .:|:||.||||:.||||.|:.|::|.:||||||..||:..|||||:|.||:|:||||......||
Human   290 FMKKIPTGAEASNVLVGEVDILDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYH 354

  Fly   569 EVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWI 633
            |:|||::|:|.:|.||.:||||.:|.|||:.|:||||...|||||.||     |...::..|: :
Human   355 EIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWD-----PSIRIEPPKN-V 413

  Fly   634 RTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPL 698
            .:::.:.:....:..:..|.::..                 ||..|.:                |
Human   414 PSQEKRKMPGVPNGNVCHIEQEPH-----------------GGHSGPE----------------L 445

  Fly   699 EKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGI 763
            ::||||:|||..|:||:.|.|.||..|.|:.:.||:.:|:|.||:|..||||||:...|...|..
Human   446 QRTGRLFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISA 510

  Fly   764 SETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIAL 828
            .|:|...|:.||.:...:.|.|.|:|:|||:|:|::.|..||..:...:||||..:|:|...:.:
Human   511 IESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCI 575

  Fly   829 TVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPL--------LSDY----NL 881
            .:.|.:.|..|..:||||:|.|::||.:|:|.|...|||.:....|:        ||.|    .|
Human   576 VLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCTL 640

  Fly   882 PP-PTLVAHEHATNESLLNAT---ASVTTNITQMVMN--ISTTAMPIGPPPLPKNQPNTALFCTI 940
            |. |.....::..:.:::.|.   |::|.:..|.:..  :.:.....||     ..|:...:..|
Human   641 PENPNNHTLQYWKDHNIVTAEVHWANLTVSECQEMHGEFMGSACGHHGP-----YTPDVLFWSCI 700

  Fly   941 LTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPS 1005
            |...||:::..||.|:.|.:.....|..:.||.|.::|...|::|:|: .|.:.||.||....|:
Human   701 LFFTTFILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVIIDFLI-GVPSPKLQVPSVFKPT 764

  Fly  1006 DPSKRGWYIG-FDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLL 1069
             ...|||.|. ...:..|...|.:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::
Human   765 -RDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMV 828

  Fly  1070 CLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSV 1134
            .::...|.|.|:||..||||.|:|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||
Human   829 AIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSV 893

  Fly  1135 LMAPLLRLIPMAVLFGVFLYMGVASMSGV------------------QLFERIRLYFMPVKHYPP 1181
            .|..:|:.|||.||:||||||||:|:.|:                  |.|:|::|:.||.||.|.
Human   894 FMTAILKFIPMPVLYGVFLYMGVSSLQGIQSQFPFLSRGNGVTYLSEQFFDRLKLFGMPAKHQPD 958

  Fly  1182 TSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALD 1246
            ..|::.:...|:||||.||:.||||||.:|:|..::.||..::.:|.:|:.:...:...|:..||
Human   959 FIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLD 1023

  Fly  1247 G----SEMKKNDD 1255
            .    |:.||.||
Human  1024 DLMPESKKKKLDD 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	356/1042 (34%)
SLC4A8	XP_011537312.1	Band_3_cyto	117..1023	CDD:452680	349/1027 (34%)