Protein Alignment Ae2 and SLC4A7

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001308032.1
• Gene: SLC4A7 / 9497
• HGNCID: 11033
• Length: 1259
• Species: Homo sapiens
• Alignment Length: 1175
• Identity: 405/1175 - (34%)
• Similarity: 611/1175 - (52%)
• Gaps: 191/1175 - (16%)

  Fly   210 ELRSHR----------SDDPRALRR---HKIHHSSIK--------LRELPQITISP-------FT 246
            ||.|||          |.:.|...|   ||.||...|        .||.|... :|       ..
Human    45 ELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYD-TPSQRVQFILG 108

  Fly   247 NKKPEVDHSPHEIFVQLDELT-GVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLN 310
            .:..:.:|.||::|.::|||. ..||:.||||||||:|:|||||:|.|||.||:||:||.|||..
Human   109 TEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFE 173

  Fly   311 LRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFT 375
            ||.|:..|.|:||:....|..:|..|::.|:....:|.:.:.:|..:||.||.|.||.:    ||
Human   174 LRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKR----FT 234

  Fly   376 KR------------KYNS-----------YTSLQFLWMGADSAHQPYQQAQP---------PPRN 408
            .|            |::.           ..|...|..|..:::...:...|         |...
Human   235 SRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSR 299

  Fly   409 LAKARRSICVT-----SSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPA 468
            ......|.|.|     .::||::..::..|:.::    ...:......|.:.:..|...:.|.|.
Human   300 AGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSS----QESQRQAPELLVSPASDDIPTVVIHPP 360

  Fly   469 AE-----IGGSKRSNELKIDMKDDMYSSSQE-----------DLK------KLQNDTI------- 504
            .|     :.|.::.||..:|:...:.:|.|.           ::|      ..:|.|:
Human   361 EEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDM 425

  Fly   505 --LKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDY 567
              :::||.||||:.||||.|:|||:|.||||||:..||:..|||||||.||:|:||||......|
Human   426 NFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQY 490

  Fly   568 HEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDW 632
            ||:||||:|||.:|.||.:||||.||.||||.|:||||...|||||.||     |...::..|.
Human   491 HEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWD-----PSIRIEPPKS- 549

  Fly   633 IRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSP 697
            :.:::.:.:.|..:.....:|:..::|               ....|.:
Human   550 VPSQEKRKIPVFHNGSTPTLGETPKEA---------------AHHAGPE---------------- 583

  Fly   698 LEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIG 762
            |::||||:|||..|:||:.|.:.||..|.|:.:.||:.:|:|.||:|..||||||:...|...|.
Human   584 LQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRIS 648

  Fly   763 ISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIA 827
            ..|:|...||.||.:...:.|||.|:|:|||:|:|::.|..||..::..:||||..:|:|...:.
Human   649 AIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLC 713

  Fly   828 LTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISI---YREN-----PLLSDYN---L 881
            :.:.|.:.|..|..:||||:|.|:|||.:|:|.|...||..:   |..|     ..|:.|:   .
Human   714 IVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCT 778

  Fly   882 PPPTLVAHEHATNESLL-----NATASVTTNITQMVMNIS-----------TTAMPIGPPPLPKN 930
            .||      :.:||:|.     |.||.   ||:...:.:|           :.....||     .
Human   779 EPP------NPSNETLAQWKKDNITAH---NISWRNLTVSECKKLRGVFLGSACGHHGP-----Y 829

  Fly   931 QPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEK 995
            .|:...:|.||...||.::.:||.|:...:.....|..:.||.|.::|.|.|.:|||| .|.:.|
Human   830 IPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLV-GVPSPK 893

  Fly   996 LVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKG 1059
            |.|||...|:.| :|||.|. ...:..|......|||||..|||||:.||:.:|:::.:..||||
Human   894 LHVPEKFEPTHP-ERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKG 957

  Fly  1060 SGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGF 1124
            :|.|.|::::.::...|.:.|:||..||||.|::||:|:.:.|...||||.|:.:.::|||::|.
Human   958 AGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGL 1022

  Fly  1125 FVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLR 1189
            .:.:::||||.|..:|:.|||.||:||||||||:|:.|:|||:||:|:.||.||.|...|::.:.
Human  1023 MIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVP 1087

  Fly  1190 PWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEM 1250
            .||:|:||.||:.||||||.:|.|..::.||..::.:|.:|:.:...:...|:..||.    |:.
Human  1088 LWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKK 1152

  Fly  1251 KKNDD 1255
            ||.||
Human  1153 KKEDD 1157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	385/1097 (35%)
		Band_3_cyto	287..618	CDD:284893	137/398 (34%)
		HCO3_cotransp	698..1199	CDD:279322	203/528 (38%)
SLC4A7	NP_001308032.1	ae	122..1144	CDD:273290	378/1082 (35%)
		Band_3_cyto	150..541	CDD:284893	137/403 (34%)
		HCO3_cotransp	584..1097	CDD:279322	203/528 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650