Protein Alignment Ae2 and Slc4a10

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001229307.1
• Gene: Slc4a10 / 94229
• MGIID: 2150150
• Length: 1136
• Species: Mus musculus
• Alignment Length: 1226
• Identity: 395/1226 - (32%)
• Similarity: 610/1226 - (49%)
• Gaps: 225/1226 - (18%)

  Fly    85 EDSEYESQTEPLNNAQNYDDIPEDFPLVSERAG-------HGDHSDNSVDEK-----HVQFGGKK 137
            |..:..:|.|||...:|      |...|.:|.|       |.:..|......     ||..||:|
Mouse     2 EIKDQGAQMEPLLPTRN------DEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRK 60

  Fly   138 KIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDTA 202
                           ||    ||.||:.::.||...:                        .|:.
Mouse    61 ---------------SH----RRHRHRGHKHRKRDRE------------------------RDSG 82

  Fly   203 LEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDELT 267
            ||:.     |...|.|..:.|...|                 ...:..:.:|.||::|.:|||:.
Mouse    83 LEDG-----RESPSFDTPSQRVQFI-----------------LGTEDDDEEHLPHDLFTELDEIC 125

  Fly   268 -GVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPA 331
             ..|||.||:|||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.||||::...:..
Mouse   126 WREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEE 190

  Fly   332 VAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQ--GVLPFTKRKYNSYTSLQFLWMGADS 394
            :|..|::|.|....::.:.:..|..:|:.:|.|.|:.:  ..:|..:         .|..:|
Mouse   191 IADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLANRIPIVR---------SFADIG--- 243

  Fly   395 AHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTD 459
                  :.|..|.::.|....:....|||..|...|..:          |.:||:.:
Mouse   244 ------KKQSEPNSMDKNAGQVVSPQSAPACAENKNDVS----------RENSTVDF-------- 284

  Fly   460 DKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEF 524
                    :..:||.::.:.....||..:........::..:...:|:||.||||:.:|||.:||
Mouse   285 --------SKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEF 341

  Fly   525 LEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYK 589
            |::..:||||||..||:..|.|||:|.||:|:||||......|||:||||:|||.:|.||.:|||
Mouse   342 LDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYK 406

  Fly   590 ADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGK 654
            |.||.||:|.|:||||...|||||.||                               ..|:|..
Mouse   407 AKDRNDLVSGIDEFLDQVTVLPPGEWD-------------------------------PSIRIEP 440

  Fly   655 DEEKALLEKQTLGAI-GFTIGGGD----GGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKR 714
            .:.....||:.:.|: ..|...|:    ||..|..             |::|||::|||..|:||
Mouse   441 PKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPE-------------LQRTGRIFGGLILDIKR 492

  Fly   715 RMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHC 779
            :.|.:.||..|..:.:.||:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:..
Mouse   493 KAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSL 557

  Fly   780 LSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTR 844
            ...|||.|:|:|||:|:|::.|..||.::...:||||..:|:|...:.:.:.|.:.|..|..:||
Mouse   558 FGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITR 622

  Fly   845 FTQEIFSALITLIYIVETFMKL--------ISIYRENPLLSDY--NLPPPTLVAHEHATN----- 894
            ||:|.|::||.:|:|.|...||        |:::.:..||:.|  |...|    |..:.:
Mouse   623 FTEEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEP----HSPSNDTLKEW 683

  Fly   895 -ESLLNATASVTTNITQMVMNIST----------TAMPIGPPPLPKNQPNTALFCTILTLATFVV 948
             ||.|:|:..:..|:|     :|.          .|...|.|.:    |:...:..||..:|..:
Mouse   684 RESNLSASDIIWGNLT-----VSECRSLHGEYVGRACGHGHPYV----PDVLFWSVILFFSTVTM 739

  Fly   949 AYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWY 1013
            :..||.|:.|.:.....|..:.||.|.::|...||:||.: .:.:.||.||....|: ...|||:
Mouse   740 SATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPT-RDDRGWF 802

  Fly  1014 I-GFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACG 1077
            : ....:..|...|.:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::.::...|.
Mouse   803 VTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCS 867

  Fly  1078 IFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRL 1142
            |.|:||..||||.|:|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|..:|:.
Mouse   868 IMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKF 932

  Fly  1143 IPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLL 1207
            |||.||:|||||||.:|:.|:|||:||:|::||.||.|...|::.:...|:||||.||:.||.||
Mouse   933 IPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLL 997

  Fly  1208 WSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPD 1259
            |.:|.|:.::.||..::.:|.:|:.:..|:...|:..||.    |:.||.:|.|.:
Mouse   998 WIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKE 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	359/1039 (35%)
		Band_3_cyto	287..618	CDD:284893	117/332 (35%)
		HCO3_cotransp	698..1199	CDD:279322	193/527 (37%)
Slc4a10	NP_001229307.1	ae	118..1061	CDD:273290	359/1039 (35%)
		Band_3_cyto	146..435	CDD:284893	117/363 (32%)
		HCO3_cotransp	476..989	CDD:279322	193/527 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.680