Protein Alignment Ae2 and SLC4A4

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001427558.1
• Gene: SLC4A4 / 8671
• HGNCID: 11030
• Length: 1110
• Species: Homo sapiens
• Alignment Length: 1155
• Identity: 400/1155 - (34%)
• Similarity: 605/1155 - (52%)
• Gaps: 198/1155 - (17%)

  Fly   146 DEQPTDQSH---------ERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDT 201
            ||:..:..|         :..|||.||    :||..|::..| |.::.||          ..:.:
Human    50 DEEEVEGHHTIYIGVHVPKSYRRRRRH----KRKTGHKEKKE-KERISEN----------YSDKS 99

  Fly   202 ALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNK----KPEVDHS--PHEIF 260
            .:|.||                    ..||..|:.|    |||...:    ..|.|.|  |.::|
Human   100 DIENAD--------------------ESSSSILKPL----ISPAAERIRFILGEEDDSPAPPQLF 140

  Fly   261 VQLDELTGV-GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDL 324
            .:||||..| |::.||||||||||:||.||:|.:||.|||||:||.|||..||.|:|.|.::||.
Human   141 TELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDR 205

  Fly   325 NEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLW 389
            ....||.:...:|:..:...|:....|..|..:||.:|||           :.|.::..||..:.
Human   206 EASSLPQLVEMIVDHQIETGLLKPELKDKVTYTLLRKHRH-----------QTKKSNLRSLADIG 259

  Fly   390 MGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGN 454
            ....||.:.:..    |.|                            .:.|:.| |:.|.|.|.:
Human   260 KTVSSASRMFTN----PDN----------------------------GSPAMTH-RNLTSSSLND 291

  Fly   455 LSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLV 519
            :|...:|                ::||                    :..:|::|..|||:.|||
Human   292 ISDKPEK----------------DQLK--------------------NKFMKKLPRDAEASNVLV 320

  Fly   520 GAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFH 584
            |.|:||:.|.||||||.:.|::..|||||||.||:|:||||:.....|||:||:|:|||::|.||
Human   321 GEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFH 385

  Fly   585 SIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEM 649
            .|||||.||.||::.|:||||:.||||||.||     |...::..|....:.|.|  .:....|.
Human   386 DIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWD-----PAIRIEPPKSLPSSDKRK--NMYSGGEN 443

  Fly   650 IKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKR 714
            :::..|....              ||..|||.||.::           |::|||..|||..|:||
Human   444 VQMNGDTPHD--------------GGHGGGGHGDCEE-----------LQRTGRFCGGLIKDIKR 483

  Fly   715 RMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHC 779
            :.|.:.||..|.||.:.|:|.:|:|.|.::.|||||||:...|::..|:.|:.:..::.|.:|..
Human   484 KAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCL 548

  Fly   780 LSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTR 844
            .:.|||.|:.:|||:|:|:..|..|...:.||:|..|:::|:|...:.|.:.|.:.|..|:..||
Human   549 FAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSAFLCLILVATDASFLVQYFTR 613

  Fly   845 FTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLV---------AHEHATNESLLNA 900
            ||:|.||:||:.|:|.:.|.|:|.:....|:.|::.:...||.         |:...:|::.|..
Human   614 FTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKVGYNTLFSCTCVPPDPANISISNDTTLAP 678

  Fly   901 TASVTTNITQMVMNISTT----------AMPIGPPPLPKN---QPNTALFCTILTLATFVVAYYL 952
            ....|.:.|.|..|  ||          ....|...:..|   .|:..|...||.|.|:..:..|
Human   679 EYLPTMSSTDMYHN--TTFDWAFLSKKECSKYGGNLVGNNCNFVPDITLMSFILFLGTYTSSMAL 741

  Fly   953 KLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI-GF 1016
            |.|:.|.:....||:.:.||.:.:||.||.::|.|| .|.|.||:||....|:.|: |||:: .|
Human   742 KKFKTSPYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEFKPTSPN-RGWFVPPF 804

  Fly  1017 DTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGM 1081
            ..:..|:..|..||||||.|||||:.||:.:||::.:..||||:|.|.|:..:.:|...|.:..:
Human   805 GENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVICSLMAL 869

  Fly  1082 PWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMA 1146
            ||:.||||.|:.|:.|:.:.:.|.||||.|:.:.|:|||::|..|.::.||||.|||:|:.|||.
Human   870 PWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMP 934

  Fly  1147 VLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVK 1211
            ||:||||||||||::|||..:|::|..||:||.|...|::.:...::||||.:|||||.|||.:|
Human   935 VLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILK 999

  Fly  1212 SSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDE 1257
            |:..::.||..::.:|.:|:.:..|:...::..||.    .:.||.:|::
Human  1000 STVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEK 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	371/1026 (36%)
SLC4A4	NP_001427558.1	None