DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ae2 and BOR1

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_014124.1	Gene:	BOR1 / 855446	SGDID:	S000005219	Length:	576	Species:	Saccharomyces cerevisiae

Alignment Length:	585	Identity:	138/585 - (23%)
Similarity:	244/585 - (41%)	Gaps:	88/585 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 SDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAIT 748
            ||:::..|..:    .:...|..|:..|||.|:|.||||.:|..|...:.:.:..||..|..||.
Yeast    42 SDEESHEKLSR----RRFPTLGIGIWLDLKDRIPYYKSDWVDAFNYRVIPSIVDTYFNNLLPAIA 102

  Fly   749 FGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFL 813
            |...:..:|::..|::|.|:|.::.||||..|..|||.|:|.|||:.:|:..:..........:.
Yeast   103 FAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISIFNYTVYEIIKPLNTSYF 167

  Fly   814 SLRVYVGVWLIIIALTVSAFEGSV-YVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLS 877
            ....::.:|.:|..| |.||..:| .::.:|.|..:||...|.::||.:....|...:
Yeast   168 GFMFWICMWSMIFHL-VLAFTNAVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF------- 224

  Fly   878 DYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILT 942
                              |..:...||......:|:.:..||.              .||
Yeast   225 ------------------SAKSGEKSVQDGFASVVVALVMTAF--------------GLF----- 252

  Fly   943 LATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISI---AIFVLVDYLVPAVYTEKLVVPEGLSP 1004
               |.:.:|..||  ||    ..|..:.|:...:|:   :.|......:..|..:||.:.:...|
Yeast   253 ---FKLFHYYPLF--SH----RIRTFISDYSTALSVLFWSSFTHFGGYLHDVKFKKLPITKAFFP 308

  Fly  1005 SDPSKRGWYIGFDTSSTW-----IPFACVIPAL----LVYILIFMESQISELIVDKPDRGLKKGS 1060
            :....|       ..:||     ||...|..||    .:.||.:.:..:|.|:..:....|||.|
Yeast   309 TSKVNR-------PQNTWLAYEPIPVKDVFIALPFGIFLTILFYFDHNVSSLMAQRHQYKLKKPS 366

  Fly  1061 GLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFF 1125
            ..|:|..||.|..|..|:.|:|.......::..|..::.:..      .:.:::...|||.:..|
Yeast   367 SFHYDFALLGLTTCISGVLGIPAPNGLIPQAPLHTETLLVRD------SNQKVISCVEQRFTNTF 425

  Fly  1126 VCLMIGLSVLMAPLLRL---IPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKR 1187
            ..||| |..:..|||..   ||.|||.|:|..||:..:....:.:|:...|........||.:.:
Yeast   426 QGLMI-LGTMTRPLLVCLGEIPQAVLSGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMK 489

  Fly  1188 LRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDGSEMKK 1252
            :....:.:|.:..:......:::.::..::.||..|::.|.:..:...::..||::.||.:..:|
Yeast   490 VSKKSMLIFLSFSLTGFAGEFAITNTIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQK 554

Fly 1253 1252
Yeast 555 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	138/585 (24%)
		Band_3_cyto	287..618	CDD:284893
		HCO3_cotransp	698..1199	CDD:279322	126/516 (24%)
BOR1	NP_014124.1	Xan_ur_permease	61..475	CDD:419983	121/481 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2296
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm46668
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
TreeFam	0	0.000	Not matched by this tool.
	9	8.740