Protein Alignment Ae2 and SLC4A11

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001167561.1
• Gene: SLC4A11 / 83959
• HGNCID: 16438
• Length: 918
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 171/571 - (29%)
• Similarity: 277/571 - (48%)
• Gaps: 60/571 - (10%)

  Fly   707 GLRNDLKRRMPMYKSDILDGLNTET------LAATIFMYFACLSTAITFGGLVSAKTNSWIGISE 765
            |:|.|:.||.|:|..|..||:..:.      :..|:|:|||||...|.||.|....|:..|.:.:
Human   372 GIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQK 436

  Fly   766 TLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTV 830
            |:...|:.|:::...|.|||||:.||.||.|:.:.:.|.|..::.||.|...:.|:|........
Human   437 TIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALY 501

  Fly   831 SAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISI---YRENPLLSDYNLPPPTLVAHEHA 892
            :.|..|:.:.|..|.|:||.:..|::.::::.....:.|   |.....|.||         |...
Human   502 AFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDY---------HTKR 557

  Fly   893 TNE--SLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLF 955
            |:.  ||....||:..:: ...:|.|..|.|...|....:...||:...::.|.|..:.|.|..|
Human   558 TSSLVSLSGLGASLNASL-HTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQF 621

  Fly   956 RNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIGFDTSS 1020
            :.|.:|....|..|.|..:||::..|             .|:...|....:.||      |..:.
Human   622 KKSPYLHPCVREILSDCALPIAVLAF-------------SLISSHGFREIEMSK------FRYNP 667

  Fly  1021 TWIPFACV-IPAL-------------LVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCL 1071
            :..|||.. |.:|             |:.:|.|:|..:...:|:.|:..|.||:..|||::||.:
Human   668 SESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAI 732

  Fly  1072 LNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGE-SPRIVDVKEQRLSGFFVCLMIGLSVL 1135
            :|....:||:||..||...|..||.::.::......|. ...||:|||.||:.....:::|||:|
Human   733 INTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLL 797

  Fly  1136 MAPL-LRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTI 1199
            :.|: |:.||..||:|:|||:.:.|:.|.||.:|:.|.......||||.|::|:...|:|.||.:
Human   798 LLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGL 862

  Fly  1200 QVLCLVLLWSVKSSQ---FSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALD 1246
            |||.|:||.:...|.   ..:.||..:|.|:|||. .|.::.:.:.:..:|
Human   863 QVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMD 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	171/571 (30%)
SLC4A11	NP_001167561.1	PtsN	<249..327	CDD:441368
		HCO3_cotransp	368..861	CDD:460009	154/517 (30%)