Protein Alignment Ae2 and SLC4A9

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_016865422.2
• Gene: SLC4A9 / 83697
• HGNCID: 11035
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 1148
• Identity: 328/1148 - (28%)
• Similarity: 516/1148 - (44%)
• Gaps: 280/1148 - (24%)

  Fly   168 QRKFSHQDSVE--------PKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRR 224
            :.|...|:..|        |..:|:.|.|.|.......|.||..:|..:.:       ||.
Human     2 EMKLPGQEGFEASSAPRNIPSGELDSNPDPGTGPSPDGPSDTESKELGVPK-------DPL---- 55

  Fly   225 HKIHHSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDELTGVGEDREWKETA---------- 279
                                              :|:||:||.|..:..||:||.
Human    56 ----------------------------------LFIQLNELLGWPQALEWRETGSSSASLLLDM 86

  Fly   280 --------------RWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLP 330
                          ||:.:||.:|..:.||..|||.:|:..||..||..|..|:||||...:.|
Human    87 GEMPSITLSTHLHHRWVLFEEKLEVAAGRWSAPHVPTLALPSLQKLRSLLAEGLVLLDCPAQSL- 150

  Fly   331 AVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSA 395
               ..:|||:...:.:....:..:...||.|.:|.|:..|..|
Human   151 ---LELVEQVTRVESLSPELRGQLQALLLQRPQHYNQTTGTRP---------------------- 190

  Fly   396 HQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDD 460
                                 |..|:.|..|:
Human   191 ---------------------CWGSTHPRKAS--------------------------------- 201

  Fly   461 KKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFL 525
                            .||             :..|::...:.:.:::|.||||.|||.|.:.||
Human   202 ----------------DNE-------------EAPLREQCQNPLRQKLPPGAEAGTVLAGELGFL 237

  Fly   526 EQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKA 590
            .||..|||||...|::.:||||.:|.||..:||||......|||:||:.:.|:::..|.....:|
Human   238 AQPLGAFVRLRNPVVLGSLTEVSLPSRFFCLLLGPCMLGKGYHEMGRAAAVLLSDPQFQWSVRRA 302

  Fly   591 DDRKDLLSAINEFLDDSIVLPPGNWD-------------RHDLLPFEELKAKKDWIRTRKIKALQ 642
            .:..|||:|::.||::..|||||.||             :|..||.::          |:|:...
Human   303 SNLHDLLAALDAFLEEVTVLPPGRWDPTARIPPPKCLPSQHKRLPSQQ----------REIRGPA 357

  Fly   643 VKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGG 707
            |.|    :...:|..:                             :|.....|. |::||||:||
Human   358 VPR----LTSAEDRHR-----------------------------HGPHAHSPE-LQRTGRLFGG 388

  Fly   708 LRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSL 772
            |..|::|::|.|.||.||.|:.:..:|.:::|.|.::.|||||||:...|:...|:.|:.:..::
Human   389 LIQDVRRKVPWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGVLESFLGTAV 453

  Fly   773 VGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSV 837
            .|..|..::.|||.|:.:|||:|:|:..|..|...:..|:|..|::||:|:....|.:.|.|.||
Human   454 AGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLVLVATEASV 518

  Fly   838 YVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPL----------LSDYNLPPPTLVAHEHA 892
            .||..||||:|.|.|||:||:|.:...|::::....|:          |..|  |.|       .
Human   519 LVRYFTRFTEEGFCALISLIFIYDAVGKMLNLTHTYPIQKPGSSAYGCLCQY--PGP-------G 574

  Fly   893 TNES-LLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQ------------PNTALFCTILTLA 944
            .||| .:........:|..|.:.:...::.  |||....|            |:.|.|..:|.|.
Human   575 GNESQWIRTRPKDRDDIVSMDLGLINASLL--PPPECTRQGGHPRGPGCHTVPDIAFFSLLLFLT 637

  Fly   945 TFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSK 1009
            :|..|..||..:.|.|.....|:.|.||...::|.:...:|..: .:.|.||:||....|:.|.
Human   638 SFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFL-GLATPKLMVPREFKPTLPG- 700

  Fly  1010 RGWYIG-FDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLN 1073
            |||.:. |..:..|...|..:||||:.|||||:.||:.:|:::.:..|:||:|.|.|:..:.:|.
Human   701 RGWLVSPFGANPWWWSVAAALPALLLSILIFMDQQITAVILNRMEYRLQKGAGFHLDLFCVAVLM 765

  Fly  1074 CACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAP 1138
            ......|:||:.:|||.|:.|:.|:...||..||||.|..:.::||||:|..|.::.|.|:.:||
Human   766 LLTSALGLPWYVSATVISLAHMDSLRRESRACAPGERPNFLGIREQRLTGLVVFILTGASIFLAP 830

  Fly  1139 LLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLC 1203
            :|:.|||.||:|:|||||||::|.:|...|::|..||.||.|....::.:...::||||.||:.|
Human   831 VLKFIPMPVLYGIFLYMGVAALSSIQFTNRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLAC 895

  Fly  1204 LVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALD 1246
            |.|||.:||:..::.||..|:.:|.:|:.|.:::.|:|:..||
Human   896 LGLLWIIKSTPAAIIFPLMLLGLVGVRKALERVFSPQELLWLD 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	314/1048 (30%)
SLC4A9	XP_016865422.2	Band_3_cyto	57..938	CDD:452680	312/1046 (30%)