DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and slc4a10a

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_021335416.1	Gene:	slc4a10a / 798983	ZFINID:	ZDB-GENE-100215-3	Length:	1211	Species:	Danio rerio

Alignment Length:	1272	Identity:	390/1272 - (30%)
Similarity:	614/1272 - (48%)	Gaps:	256/1272 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SQTEPLNNAQNYDDIPEDFPLVSERAGHGDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPTDQSH- 154
            :|.|||            .|.|...|...:..|   :|..:..||.:.: .:.:::::.. :.|
Zfish     8 AQMEPL------------LPAVQSPASDSERQD---EEAVLDRGGTRSM-LNTNFEKEEL-EGHR 55

  Fly   155 -----------ERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDTALEEADL 208
                       .|..||.||..:|.||.|.:                        .|:..|:.
Zfish    56 TLYIGVHVPLGRRSHRRHRHHGHRHRKRSRE------------------------RDSGTEDG-- 94

  Fly   209 NELRSHRSDDPRALRRHKIHHSSIKLRELPQITISP------FTNKKPEVDHSPHEIFVQLDEL- 266
                                      ||.|..|.:|      ....:.:.:|.||.:|.:|||:
Zfish    95 --------------------------RESPSYTDTPSQRVQFLLGMEDDEEHIPHALFTELDEIC 133

  Fly   267 TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPA 331
            ...|||.||||||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.|:||:....|..
Zfish   134 LKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVMLDMRASSLEE 198

  Fly   332 VAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNE-----------------------HQGVLP 373
            :|..|::|......:....:..:..:||.:|.|.|:                       |.....
Zfish   199 IADMVLDQHETSGPLGEEVRKKIRNALLKQHHHQNQKKLANRIPIVRSFADIGRKQSEPHSMDKN 263

  Fly   374 FTKRKYNSYTSLQFLWMGADSAHQPYQQAQPP------PRNLAKARR-SICVTSSAPPTAAMLNV 431
            .|...::|.:.....|....|:.:..|....|      |:.::..:: ..|.:::..|.::::.
Zfish   264 VTTTSHSSPSPCCSFWSRFSSSVRDRQVLLCPDWPLRCPKCVSSPQKLHPCPSATPAPNSSLIR- 327

  Fly   432 ATATAAAAAIDHRRH----------------STMSY-----LGNLSGTDDKKIKIMPAAEIGGSK 475
                      .|:.|                .|:::     .|.:.....:.|......|  ||:
Zfish   328 ----------HHKTHIPFSKRLSPPYGYHVIPTLNFEEESPSGQMVSPQTQPINTEGRGE--GSR 380

  Fly   476 RSNEL---KIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSE 537
            .::.:   |||:.                  .:|:||.||||:.:|||.:||||:|.:||:|||.
Zfish   381 ENSAVDFSKIDLH------------------FMKKIPPGAEASNILVGELEFLEKPVVAFIRLSP 427

  Fly   538 GVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINE 602
            .||:..|.|||:..||:|:||||......|||:||||:|||.:|.||.:||||.:|.||::.|:|
Zfish   428 AVLLNGLAEVPITTRFLFILLGPMGKGPQYHEIGRSIATLMTDEVFHDVAYKAKERSDLVAGIDE 492

  Fly   603 FLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLG 667
            |||...|||||.||     |...::..|:.....|.|...:....  ..:|::||.
Zfish   493 FLDQVTVLPPGEWD-----PTIRIEPPKNVPSQEKRKVPPLANGG--ADLGEEEEH--------- 541

  Fly   668 AIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETL 732
                   ||.||.:                |::|||::|||..|:||:.|.|.||..|.|:.:.|
Zfish   542 -------GGHGGPE----------------LQRTGRIFGGLFLDIKRKAPHYLSDYTDALSLQCL 583

  Fly   733 AATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLF 797
            |:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:...:.|||.|:|:|||:|:|
Zfish   584 ASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVF 648

  Fly   798 DEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVET 862
            ::.|..||.::...:|||||.:|:|.....|.:.|.:.|..|..:||||:|.|::||.:|:|.|.
Zfish   649 EKILFKFCKEYGLSYLSLRVCIGLWTAFFCLLLVATDASSLVCYITRFTEEAFASLICIIFIYEA 713

  Fly   863 FMKLISIYRENPL--------LSDYN----LPPPTLVAHEHATNESL-----LNATAS----VTT 906
            ..|||.:....|.        |:.|:    :|       :..:|.:|     .|.|||    :..
Zfish   714 LEKLIHLGETYPFNMHNDLNKLTQYSCVCTIP-------KEPSNATLKYWEEKNITASEIDWLGL 771

  Fly   907 NITQMVMN----ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARR 967
            ::...|.|    :.:.....||     ..|:...:..:|..:|..::.:||.|:.|.:.....|:
Zfish   772 DVKGCVENRGEFVGSACGHHGP-----YIPDVLFWSVVLFFSTVAMSSFLKEFKTSRYFPTKVRQ 831

  Fly   968 ALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFACVIPA 1031
            .:.||.|.|:|...||:||.: .|.:.||.||....|: ...|||.|. ...:..|......|||
Zfish   832 IISDFAVFITIMTMVLIDYGL-GVPSPKLQVPNVFKPT-RDDRGWIISPLGPNPWWTVIVTCIPA 894

  Fly  1032 LLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVS 1096
            ||..|||||:.||:.:|:::.:..||||.|.|.|:.::.::...|.:.|:||..||||.|::||:
Zfish   895 LLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLFVVGVMLGVCSVMGLPWFVAATVLSISHVN 959

  Fly  1097 SVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMS 1161
            |:.:.|...||||.|:.:.::|||.:|..:.:::|.||.|..:|:.|||.||:|||||||.:|:.
Zfish   960 SLKLESECSAPGEQPKFLGIREQRFTGLMIFVLMGSSVFMTSVLKHIPMPVLYGVFLYMGASSLR 1024

  Fly  1162 GVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMM 1226
            |:|.|:|::|:.||.||.|...|::.:...|:|:||.||:.||||||.:|:|:.::.||..::.:
Zfish  1025 GIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHMFTIIQLSCLVLLWVIKTSRAAIVFPMMVLAL 1089

  Fly  1227 VPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPD 1259
            |.||:.|..::...::..||.    |:.||.:|.:.:
Zfish  1090 VFIRKLLDFVFSKRDLSWLDDLMPESKKKKMEDAQQE 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	359/1085 (33%)
		Band_3_cyto	287..618	CDD:284893	117/384 (30%)
		HCO3_cotransp	698..1199	CDD:279322	191/526 (36%)
slc4a10a	XP_021335416.1	Band_3_cyto	126..1130	CDD:331698	359/1085 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575047
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.780