Protein Alignment Ae2 and slc4a10a

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_073772542.1
• Gene: slc4a10a / 798983
• ZFINID: ZDB-GENE-100215-3
• Length: 1212
• Species: Danio rerio
• Alignment Length: 1272
• Identity: 390/1272 - (30%)
• Similarity: 614/1272 - (48%)
• Gaps: 256/1272 - (20%)

  Fly    91 SQTEPLNNAQNYDDIPEDFPLVSERAGHGDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPTDQSH- 154
            :|.|||            .|.|...|...:..|   :|..:..||.:.: .:.:::::.. :.|
Zfish     8 AQMEPL------------LPAVQSPASDSERQD---EEAVLDRGGTRSM-LNTNFEKEEL-EGHR 55

  Fly   155 -----------ERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDTALEEADL 208
                       .|..||.||..:|.||.|.:                        .|:..|:.
Zfish    56 TLYIGVHVPLGRRSHRRHRHHGHRHRKRSRE------------------------RDSGTEDG-- 94

  Fly   209 NELRSHRSDDPRALRRHKIHHSSIKLRELPQITISP------FTNKKPEVDHSPHEIFVQLDEL- 266
                                      ||.|..|.:|      ....:.:.:|.||.:|.:|||:
Zfish    95 --------------------------RESPSYTDTPSQRVQFLLGMEDDEEHIPHALFTELDEIC 133

  Fly   267 TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPA 331
            ...|||.||||||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.|:||:....|..
Zfish   134 LKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVMLDMRASSLEE 198

  Fly   332 VAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNE-----------------------HQGVLP 373
            :|..|::|......:....:..:..:||.:|.|.|:                       |.....
Zfish   199 IADMVLDQHETSGPLGEEVRKKIRNALLKQHHHQNQKKLANRIPIVRSFADIGRKQSEPHSMDKN 263

  Fly   374 FTKRKYNSYTSLQFLWMGADSAHQPYQQAQPP------PRNLAKARR-SICVTSSAPPTAAMLNV 431
            .|...::|.:.....|....|:.:..|....|      |:.::..:: ..|.:::..|.::::.
Zfish   264 VTTTSHSSPSPCCSFWSRFSSSVRDRQVLLCPDWPLRCPKCVSSPQKLHPCPSATPAPNSSLIR- 327

  Fly   432 ATATAAAAAIDHRRH----------------STMSY-----LGNLSGTDDKKIKIMPAAEIGGSK 475
                      .|:.|                .|:::     .|.:.....:.|......|  ||:
Zfish   328 ----------HHKTHIPFSKRLSPPYGYHVIPTLNFEEESPSGQMVSPQTQPINTEGRGE--GSR 380

  Fly   476 RSNEL---KIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSE 537
            .::.:   |||:.                  .:|:||.||||:.:|||.:||||:|.:||:|||.
Zfish   381 ENSAVDFSKIDLH------------------FMKKIPPGAEASNILVGELEFLEKPVVAFIRLSP 427

  Fly   538 GVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINE 602
            .||:..|.|||:..||:|:||||......|||:||||:|||.:|.||.:||||.:|.||::.|:|
Zfish   428 AVLLNGLAEVPITTRFLFILLGPMGKGPQYHEIGRSIATLMTDEVFHDVAYKAKERSDLVAGIDE 492

  Fly   603 FLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLG 667
            |||...|||||.||     |...::..|:.....|.|...:....  ..:|::||.
Zfish   493 FLDQVTVLPPGEWD-----PTIRIEPPKNVPSQEKRKVPPLANGG--ADLGEEEEH--------- 541

  Fly   668 AIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETL 732
                   ||.||.:                |::|||::|||..|:||:.|.|.||..|.|:.:.|
Zfish   542 -------GGHGGPE----------------LQRTGRIFGGLFLDIKRKAPHYLSDYTDALSLQCL 583

  Fly   733 AATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLF 797
            |:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:...:.|||.|:|:|||:|:|
Zfish   584 ASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVF 648

  Fly   798 DEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVET 862
            ::.|..||.::...:|||||.:|:|.....|.:.|.:.|..|..:||||:|.|::||.:|:|.|.
Zfish   649 EKILFKFCKEYGLSYLSLRVCIGLWTAFFCLLLVATDASSLVCYITRFTEEAFASLICIIFIYEA 713

  Fly   863 FMKLISIYRENPL--------LSDYN----LPPPTLVAHEHATNESL-----LNATAS----VTT 906
            ..|||.:....|.        |:.|:    :|       :..:|.:|     .|.|||    :..
Zfish   714 LEKLIHLGETYPFNMHNDLNKLTQYSCVCTIP-------KEPSNATLKYWEEKNITASEIDWLGL 771

  Fly   907 NITQMVMN----ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARR 967
            ::...|.|    :.:.....||     ..|:...:..:|..:|..::.:||.|:.|.:.....|:
Zfish   772 DVKGCVENRGEFVGSACGHHGP-----YIPDVLFWSVVLFFSTVAMSSFLKEFKTSRYFPTKVRQ 831

  Fly   968 ALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFACVIPA 1031
            .:.||.|.|:|...||:||.: .|.:.||.||....|: ...|||.|. ...:..|......|||
Zfish   832 IISDFAVFITIMTMVLIDYGL-GVPSPKLQVPNVFKPT-RDDRGWIISPLGPNPWWTVIVTCIPA 894

  Fly  1032 LLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVS 1096
            ||..|||||:.||:.:|:::.:..||||.|.|.|:.::.::...|.:.|:||..||||.|::||:
Zfish   895 LLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLFVVGVMLGVCSVMGLPWFVAATVLSISHVN 959

  Fly  1097 SVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMS 1161
            |:.:.|...||||.|:.:.::|||.:|..:.:::|.||.|..:|:.|||.||:|||||||.:|:.
Zfish   960 SLKLESECSAPGEQPKFLGIREQRFTGLMIFVLMGSSVFMTSVLKHIPMPVLYGVFLYMGASSLR 1024

  Fly  1162 GVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMM 1226
            |:|.|:|::|:.||.||.|...|::.:...|:|:||.||:.||||||.:|:|:.::.||..::.:
Zfish  1025 GIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHMFTIIQLSCLVLLWVIKTSRAAIVFPMMVLAL 1089

  Fly  1227 VPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPD 1259
            |.||:.|..::...::..||.    |:.||.:|.:.:
Zfish  1090 VFIRKLLDFVFSKRDLSWLDDLMPESKKKKMEDAQQE 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	359/1085 (33%)
slc4a10a	XP_073772542.1	None