Protein Alignment Ae2 and SLC4A2

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_003031.3
• Gene: SLC4A2 / 6522
• HGNCID: 11028
• Length: 1241
• Species: Homo sapiens
• Alignment Length: 1304
• Identity: 498/1304 - (38%)
• Similarity: 712/1304 - (54%)
• Gaps: 249/1304 - (19%)

  Fly    26 KSGNEDPDEVLLDSEMDKVFAGNSARKDKFDVNTFQDNSQLPIGSRKKNSIRTNDLNIEEDSEYE 90
            :.|.||.||.   ||.:    |..|......|:|             .:|::   ..::||...:
Human   122 EEGEEDEDEA---SEAE----GARALTQPSPVST-------------PSSVQ---FFLQEDDSAD 163

  Fly    91 ---SQTEPLNNAQNYDDIPEDFPLVSERAGHGDHSDNSVDEKHVQF------------GGK--KK 138
               .:|.|.:.|      |......:.||..|..:...|:|...:.            ||.  :.
Human   164 RKAERTSPSSPA------PLPHQEATPRASKGAQAGTQVEEAEAEAVAVASGTAGGDDGGASGRP 222

  Fly   139 IPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVE-------PKNKLEENGDAGARRISV 196
            :|.:     ||..:|:..:.|         |:.......|       |.:::|..
Human   223 LPKA-----QPGHRSYNLQER---------RRIGSMTGAEQALLPRVPTDEIEAQ---------- 263

  Fly   197 QPEDTALEEADLNELRSHRSDDPRALRRHKIH-------HSSIKLRELPQITISPFTNKKPEVDH 254
                 .|..|||:.::|||.:|...:|||.:.       .|..:.|| |    .|....:|...|
Human   264 -----TLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQSGREGRE-P----GPTPRARPRAPH 318

  Fly   255 SPHEIFVQLDE-LTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETG 318
            .|||:||:|:| |....::.:|:|||||||:||||||.::||||||||||||.|||.|||.|..|
Human   319 KPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHG 383

  Fly   319 VVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYT 383
            .|||||:::.||.||::|||||||.|.|...|:.:|:|:|||:|.|        |..::.::...
Human   384 AVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSH--------PSDEKDFSFPR 440

  Fly   384 SLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHST 448
            ::....:|:...|...|.|:..|                                       |.|
Human   441 NISAGSLGSLLGHHHGQGAESDP---------------------------------------HVT 466

  Fly   449 MSYLGNLSGTD---DKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPA 510
            ...:|.:..|.   :::.::.|.|...|..|             |.|:.:||      :|::||.
Human   467 EPLMGGVPETRLEVERERELPPPAPPAGITR-------------SKSKHELK------LLEKIPE 512

  Fly   511 GAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSIS 575
            .||||.||||.||||.:||:|||||.|.|.:..:.||||||||:|:||||.:.::||||:|||||
Human   513 NAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSIS 577

  Fly   576 TLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLL----PFEELKAKKDWIRTR 636
            |||:::.||..||.||:|:|||:|||.|||.|:||||......:||    .|:....||...:.|
Human   578 TLMSDKQFHEAAYLADEREDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGR 642

  Fly   637 KI---KALQVKRDSEMIKIGKDEEKALLEK-QTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSP 697
            .:   ..|:.|         ..::||||:. :..||               ::||         |
Human   643 LLPTGAGLEPK---------SAQDKALLQMVEAAGA---------------AEDD---------P 674

  Fly   698 LEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIG 762
            |.:|||.:|||..|::||.|.|.||..|.|:.:.|||.||:|||.||.|||||||:..||...||
Human   675 LRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIG 739

  Fly   763 ISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIA 827
            :||.::|.:|.|:||..|..|||::||.:||||:|:||...||:.:..::|..||::|.||:.:|
Human   740 VSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFLA 804

  Fly   828 LTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEH- 891
            |.:.|.|||..||.::|||||||:.||:||:|.|||.||:.|::|:||               |
Human   805 LLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHPL---------------HG 854

  Fly   892 --ATNESLLNATASVTTNITQMVMNISTTAMP-IGP----------PPLPKNQPNTALFCTILTL 943
              |:|.|.::...::|.          ..|.| :||          ...|:.||||||...:|..
Human   855 CSASNSSEVDGGENMTW----------AGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMA 909

  Fly   944 ATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPS 1008
            .||.:|::|:.|:||.|.....||.:|||||||:|.|.|||||.:...||:||.||.|.|.:.|.
Human   910 GTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPE 974

  Fly  1009 KRGWYIG----FDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLL 1069
            ||||.|.    ......|:..|.::||:||:||||||:||:.||:.|.:|.|:||||.|.|::|:
Human   975 KRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLI 1039

  Fly  1070 CLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSV 1134
            ..:...|.:||:||..|||||||||.:::|:||:..|||:.|:|.:|||||::|..|.|::|||:
Human  1040 VAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSI 1104

  Fly  1135 LMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTI 1199
            ::..|||.||:|||||:||||||.|::|:|.:||:.|..||.||:|..:|||::|..::||||.:
Human  1105 VIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTLRMHLFTAL 1169

  Fly  1200 QVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKNDDDEPDFYEQ 1263
            |:|||.|||:|.|:..||||||.||:.||:|. .||:::...||:.||.:|.:...|:.....|.
Human  1170 QLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREMKCLDANEAEPVFDEREGVDEY 1234

  Fly  1264 TNIP 1267
            ..:|
Human  1235 NEMP 1238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	442/1037 (43%)
SLC4A2	NP_003031.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..240		30/160 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..320		7/36 (19%)
		ae	324..1240	CDD:273290	443/1039 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..471		6/60 (10%)
		Membrane (anion exchange)	708..1241		257/556 (46%)