Protein Alignment Ae2 and SLC4A1

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_000333.1
• Gene: SLC4A1 / 6521
• HGNCID: 11027
• Length: 911
• Species: Homo sapiens
• Alignment Length: 1111
• Identity: 415/1111 - (37%)
• Similarity: 599/1111 - (53%)
• Gaps: 222/1111 - (19%)

  Fly   174 QDSVEPKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELP 238
            ||..|  :.:|||.:      ..:.||..:.|:.:.|..:| ..:..|...|...|
Human     5 QDDYE--DMMEENLE------QEEYEDPDIPESQMEEPAAH-DTEATATDYHTTSH--------- 51

  Fly   239 QITISPFTNKKPEVDHSPHEIFVQLDELTGVGEDRE--WKETARWIKYEEDVEEGSDRWGKPHVA 301
                 |.|          |:::|:|.||....:::|  |.|.|||::.||::.| :..||:||::
Human    52 -----PGT----------HKVYVELQELVMDEKNQELRWMEAARWVQLEENLGE-NGAWGRPHLS 100

  Fly   302 SLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVN 366
            .|:|.|||.|||....|.|||||.|..|..||.:::::.:.||.|...|:..::|:|||:|.|..
Human   101 HLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAG 165

  Fly   367 EHQ---GVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAM 428
            |.:   ||.|                                          ..:|.|..|:..:
Human   166 ELEALGGVKP------------------------------------------AVLTRSGDPSQPL 188

  Fly   429 LNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQ 493
            |              .:||::            :.::......||:            :.:|.|
Human   189 L--------------PQHSSL------------ETQLFCEQGDGGT------------EGHSPS- 214

  Fly   494 EDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLL 558
                     .||::||..:|||.||||..:|||||.:.||||.|...:..: |:|||:||:||||
Human   215 ---------GILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAV-ELPVPIRFLFVLL 269

  Fly   559 GPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPF 623
            ||....:||.::||:.:|||:...|...||.|..|.:||.::..|||.|:||||.:      .|.
Human   270 GPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTD------APS 328

  Fly   624 EE-----LKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGD 683
            |:     :..:::.:| |:.::...|.||...|                  |..:.||
Human   329 EQALLSLVPVQRELLR-RRYQSSPAKPDSSFYK------------------GLDLNGG------- 367

  Fly   684 SDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAIT 748
             .||         ||::||:|:|||..|::||.|.|.|||.|..:.:.|||.||:|||.||.|||
Human   368 -PDD---------PLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAIT 422

  Fly   749 FGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFL 813
            ||||:..||.:.:|:||.|||.::.||:|..|..|||:::|.:||||:|:||...||..:..:::
Human   423 FGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYI 487

  Fly   814 SLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSD 878
            ..||::|.|||::.:.|.|||||..||.::|:||||||.||:||:|.|||.|||.|::::||...
Human   488 VGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKT 552

  Fly   879 YNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTL 943
            ||                                .|:.....|.||      .|||||...:|..
Human   553 YN--------------------------------YNVLMVPKPQGP------LPNTALLSLVLMA 579

  Fly   944 ATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPS 1008
            .||..|..|:.|:||.:.....||.:|||||||||.|.||||:.:...||:||.||:|...|:.|
Human   580 GTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSS 644

  Fly  1009 KRGWYI---GFDTS-STWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLL 1069
            .|||.|   |..:. ..|:.||..:|||||:||||:||||:.|||.||:|.:.||||.|.|::|:
Human   645 ARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLV 709

  Fly  1070 CLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSV 1134
            ..:.....:|||||..|.|||||||.:::|:|.:...||.:.:|.:|||||:||..|.:::|||:
Human   710 VGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSI 774

  Fly  1135 LMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTI 1199
            ||.|:|..||:|||||:||||||.|:||:|||:||.|.|.|.|::|...||||::.|::||||.|
Human   775 LMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGI 839

  Fly  1200 QVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKL-YKPEEMQALDGSEMKKNDDDEP--DFY 1261
            |::||.:||.|||:..|||.||.||:.||:|:.|..| ::..|:|.||..:.|...|:|.  |.|
Human   840 QIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEY 904

  Fly  1262 EQTNIP 1267
            ::..:|
Human   905 DEVAMP 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	397/1023 (39%)
		Band_3_cyto	287..618	CDD:284893	102/333 (31%)
		HCO3_cotransp	698..1199	CDD:279322	239/504 (47%)
SLC4A1	NP_000333.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		11/43 (26%)
		Globular	55..290		99/326 (30%)
		ae	58..910	CDD:273290	397/1023 (39%)
		Interaction with ANK1. /evidence=ECO:0000305	176..185		2/8 (25%)
		Dimerization arm	304..357		17/59 (29%)
		Involved in anion transport	559..630		33/76 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142075
Domainoid	1	1.000	61	1.000	Domainoid score	I10467
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	847	1.000	Inparanoid score	I441
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173913at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm41647
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	LDO	PTHR11453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790