DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ae2 and SLC4A1

DIOPT Version :10

Sequence 1:NP_648357.1 Gene:Ae2 / 39147 FlyBaseID:FBgn0036043 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_000333.1 Gene:SLC4A1 / 6521 HGNCID:11027 Length:911 Species:Homo sapiens


Alignment Length:37 Identity:10/37 - (27%)
Similarity:10/37 - (27%) Gaps:21/37 - (56%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PPPSPPPPS---------------------PPPPACP 75
            |.|||.|.|                     .||..||
Human   210 PSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCP 246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ae2NP_648357.1 Band_3_cyto 260..1267 CDD:452680
SLC4A1NP_000333.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
(Microbial infection) Interaction with P.falciparum (isolate K1) FBPA. /evidence=ECO:0000269|PubMed:2204832 13..31
Globular 55..290 10/37 (27%)
ae 58..910 CDD:273290 10/37 (27%)
Interaction with ANK1. /evidence=ECO:0000305 176..185
Dimerization arm 304..357
Involved in anion transport 559..630
(Microbial infection) 5ABC region, interaction with P.falciparum (isolate 3D7) MSP9. /evidence=ECO:0000269|PubMed:14630931 720..761
Blue background indicates that the domain is not in the aligned region.

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