Protein Alignment Ae2 and Slc4a8

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_067505.2
• Gene: Slc4a8 / 59033
• MGIID: 1928745
• Length: 1089
• Species: Mus musculus
• Alignment Length: 1143
• Identity: 379/1143 - (33%)
• Similarity: 590/1143 - (51%)
• Gaps: 194/1143 - (16%)

  Fly   179 PKNKLEENGDAGARRISVQPEDTALEEA-----------DLNELRSHRS--------DDPRALRR 224
            |....|.:|....:|    |::.|:.:.           :..||..||:        ...::.|.
Mouse     2 PAGSNEPDGVLSYQR----PDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRH 62

  Fly   225 HKIHHSSIKLR-------------------ELPQITISPFTNKKPEVDHSPHEIFVQLDEL-TGV 269
            |:.|....:.|                   :.|...:......:.:.:|.|||:|.:|||: ...
Mouse    63 HRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKE 127

  Fly   270 GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAY 334
            |||.||||||||:|:|||||:|.:||.||:||:||.|||..||.||..|.||||:....:..::.
Mouse   128 GEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISD 192

  Fly   335 RVVEQMVIEDLIDIND--KPSVMRSLLLRHRHVNEHQ--GVLPFTKRKYNSYTSLQFLWMGADSA 395
            .:::|.  |.|.|::|  :..|..:||.:|.|.||.:  .::|..:         .|..:|
Mouse   193 LILDQQ--ELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVR---------SFAEVG---- 242

  Fly   396 HQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDD 460
                 :.|..|.::.:..:::     :|.:|..|.|....       :..||.:    :||
Mouse   243 -----KKQSDPHSMDRDGQTV-----SPQSATNLEVKNGV-------NCEHSPV----DLS---- 282

  Fly   461 KKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFL 525
                                |:|:.                  .:|:||.||||:.||||.|:.|
Mouse   283 --------------------KVDLH------------------FMKKIPTGAEASNVLVGEVDTL 309

  Fly   526 EQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKA 590
            ::|.:||||||..||:..|||||:|.||:|:||||......|||:|||::|:|.:|.||.:||||
Mouse   310 DRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKA 374

  Fly   591 DDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKD 655
            .:|.|||:.|:||||...|||||.||     |...::..|: :.:::.:.:....:..:..|..:
Mouse   375 KERDDLLAGIDEFLDQVTVLPPGEWD-----PSIRIEPPKN-VPSQEKRKMPGVPNGNVCHIEPE 433

  Fly   656 EEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYK 720
            ..                 ||..|.:                ||:||||:|||..|:||:.|.|.
Mouse   434 PH-----------------GGHSGPE----------------LERTGRLFGGLVLDVKRKAPWYW 465

  Fly   721 SDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPL 785
            ||..|.|:.:.||:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:...:.|||
Mouse   466 SDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPL 530

  Fly   786 VIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIF 850
            .|:|:|||:|:|::.|..||..:...:||||..:|:|...:.:.:.|.:.|..|..:||||:|.|
Mouse   531 TILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAF 595

  Fly   851 SALITLIYIVETFMKLISIYRENPL-----LSDYNLPPPTLVAHEHATNESL--------LNAT- 901
            ::||.:|:|.|...|||.:....|:     |...:|.....|..|:..|.:|        |.|.
Mouse   596 ASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEV 660

  Fly   902 --ASVTTNITQMVMN--ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLG 962
              |::|.:..|.:..  :.:.....||     ..|:...:..||..|||:|:..||.|:.|.:..
Mouse   661 NWANLTVSECQEMHGEFMGSACGHHGP-----YTPDVLFWSCILFFATFIVSSTLKTFKTSRYFP 720

  Fly   963 RNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFA 1026
            ...|..:.||.|.::|...|::|:|: .|.:.||.||....|: ...|||:|. ...:..|...|
Mouse   721 TRVRSMVSDFAVFLTIFTMVVLDFLI-GVPSPKLQVPNVFKPT-RDDRGWFINPIGPNPWWTVIA 783

  Fly  1027 CVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRS 1091
            .:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::.::...|.|.|:||..||||.|
Mouse   784 AIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLS 848

  Fly  1092 VTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMG 1156
            :|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|..:|:.|||.||:|||||||
Mouse   849 ITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMG 913

  Fly  1157 VASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPF 1221
            |:|:.|:|.|:|::|:.||.||.|...|::.:...|:||||.:|:.||||||.:|:|..::.||.
Mouse   914 VSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPM 978

  Fly  1222 FLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDD 1255
            .::.:|.:|:.:...:...|:..||.    |:.||.||
Mouse   979 MVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDD 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	360/1024 (35%)
		Band_3_cyto	287..618	CDD:284893	117/334 (35%)
		HCO3_cotransp	698..1199	CDD:279322	198/519 (38%)
Slc4a8	NP_067505.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..90		4/34 (12%)
		ae	117..1003	CDD:273290	353/1009 (35%)
		Band_3_cyto	145..402	CDD:284893	117/339 (35%)
		HCO3_cotransp	443..956	CDD:279322	198/519 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.680