DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and SLC4A5

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_067019.3	Gene:	SLC4A5 / 57835	HGNCID:	18168	Length:	1137	Species:	Homo sapiens

Alignment Length:	1242	Identity:	381/1242 - (30%)
Similarity:	626/1242 - (50%)	Gaps:	241/1242 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ERAGHG--DHSDNSVDEKHVQFGGKKKIP------PSLSYDEQPTDQSHERKRRRSRHQYYRQRK 170
            |:||.|  ||:::     ..:|..:|:.|      |..:|.::.|||.......:..|...|..
Human     6 EKAGVGKLDHTNH-----RRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWGLRPD- 64

  Fly   171 FSHQDSVEPKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLR 235
                   :|:.:|...| :||     ..:|::::...       |:..|.|             .
Human    65 -------QPQQELTGPG-SGA-----SSQDSSMDLIS-------RTRSPAA-------------E 96

  Fly   236 ELPQITISPFTNKKPEVDHSPH-EIFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPH 299
            :|..|.        .|.|.:|: .:|.::|.|...|:..||||:|||||:||.||||.:||.|||
Human    97 QLQDIL--------GEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKPH 153

  Fly   300 VASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRH 364
            |::||.|||..||.||:||.|||||:...||.:...|:|:.:.:.|:....:..|...||.||||
Human   154 VSTLSLHSLFELRTCLQTGTVLLDLDSGSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRH 218

  Fly   365 VNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAML 429
                                               |..:|..|:||...:|:..|:.:|
Human   219 -----------------------------------QTKKPIHRSLADIGKSVSTTNRSP------ 242

  Fly   430 NVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIG-----GSKRSNELKIDMKDDMY 489
              |.:..|..::.|             .|:|  :::..:|..|     .|:..|::.:....|.
Human   243 --ARSPGAGPSLHH-------------STED--LRMRQSANYGRLCHAQSRSMNDISLTPNTDQ- 289

  Fly   490 SSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFM 554
                      :.:..:|:||..:||:.||||.|:||:||.||||||.:..::..:||||||.||:
Human   290 ----------RKNKFMKKIPKDSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFL 344

  Fly   555 FVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHD 619
            |:||||......|:|:||:|:|||.::.|..:||||.:|:||::.|:||||:.||||||.||.:
Human   345 FILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPN- 408

  Fly   620 LLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGG--------- 675
                         ||....|.:.          ..|:.|::.....||.:..::||
Human   409 -------------IRIEPPKKVP----------SADKRKSVFSLAELGQMNGSVGGGGGAPGGGN 450

  Fly   676 ------------GDGGGDGDSDDDNGRKKKKPSPLEK---TGRLWGGLRNDLKRRMPMYKSDILD 725
                        |.||..|.|..|:|.........|:   |||.:|||..|:||::|.:.||..|
Human   451 GGGGGGGSGGGAGSGGAGGTSSGDDGEMPAMHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYD 515

  Fly   726 GLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGT 790
            |.:.::::|.:|:|..|::.|||||||:...|:::.|:.|:.:..::.|.:|...|.|||:|:.:
Human   516 GFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSS 580

  Fly   791 TGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALIT 855
            |||:|:|::.|..|...:..|::..|:::|:...:..|.:.|.:.|..::.:||||:|.||.||:
Human   581 TGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLIS 645

  Fly   856 LIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHE------HATNESLLNATASVTTNITQMVMN 914
            .|:|.:...|:|..::..|:..|:.  |..:..::      ...|.::.||:|.:..:....:.|
Human   646 FIFIYDAIKKMIGAFKYYPINMDFK--PNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYN 708

  Fly   915 -ISTTAMPIGPPPLPKNQ----------------PNTALFCTILTLATFVVAYYLKLFRNSHFLG 962
             ::.||:...  .|.|.:                |:.||...||...|:.:...||.|:.|.:..
Human   709 LLNLTALDWS--LLSKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFP 771

  Fly   963 RNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFA 1026
            ...|..:.||.:..||.:|..:|... .:.|.||.||..:.|:.|. |||::. |..:..|:..|
Human   772 TKVRALVADFSIVFSILMFCGIDACF-GLETPKLHVPSVIKPTRPD-RGWFVAPFGKNPWWVYPA 834

  Fly  1027 CVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRS 1091
            .::|||||.|||||:.||:.:||::.:..|||.:|.|.|:..:.:|...|...|:||:.||||.|
Human   835 SILPALLVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVIS 899

  Fly  1092 VTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMG 1156
            :.|:.|:.:.:.|.||||.|:.:.|:|||::|..|.::.|:||.:||:|:.||:.||:|||||||
Human   900 IAHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVFLYMG 964

  Fly  1157 VASMSGVQL----------------FERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLV 1205
            |||::|:|:                :||.:|:.||.||.|..::::.:...::||||.:|:|||.
Human   965 VASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLA 1029

  Fly  1206 LLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKND------------ 1254
            :||.:||:..::.||..::.::.:|:.|..::...::..:|.    .|.|:.|
Human  1030 VLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKETDKKRKRKKGAHED 1094

  Fly  1255 -DDEPDF 1260
             |:||.|
Human  1095 CDEEPQF 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	351/1087 (32%)
		Band_3_cyto	287..618	CDD:284893	118/335 (35%)
		HCO3_cotransp	698..1199	CDD:279322	182/543 (34%)
SLC4A5	NP_067019.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		14/50 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..94		7/50 (14%)
		ae	114..1070	CDD:273290	343/1054 (33%)
		Band_3_cyto	141..408	CDD:284893	118/335 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..255		10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..478		9/39 (23%)
		HCO3_cotransp	488..1023	CDD:279322	181/540 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1137		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750