DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and slc4a2b

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001107912.1	Gene:	slc4a2b / 570716	ZFINID:	ZDB-GENE-030429-14	Length:	1232	Species:	Danio rerio

Alignment Length:	1282	Identity:	506/1282 - (39%)
Similarity:	717/1282 - (55%)	Gaps:	232/1282 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SQLPIGSRKKNSIR----------------TNDLNIEEDSEYESQTEPLNNAQNYDDIPEDFPLV 112
            |:||..:|:|.|.|                :..|.||| .|.|.:.|...:|:|....|.  |.:
Zfish    88 SKLPGDNRRKKSGRKRRRSSSKPHKVCSSPSGALAIEE-GEDEEEEEEEESAENQSVTPA--PTI 149

  Fly   113 SERAGHGDHSDN-----SVDEKHVQFGGKKK--------IPPSLSYDEQPTDQS----------- 153
            .     .:..||     |.|:.||.......        |.|:.:...:|.|.:
Zfish   150 D-----NERKDNVQFFVSDDDPHVSTPETSDPVPTRGILIVPTTAVCSEPQDSTSTEASEAAPAS 209

  Fly   154 -----HERKRRRSRHQY--YRQRKFSHQDSVEPKNKLEENGDAGARRISV-QPEDTALEEADLNE 210
                 |....|.|...|  ..:|:..:....|         .|..:||.. :.|...|..|||:.
Zfish   210 PSTAEHGSIPRVSSRSYDLQERRRTGNMTGTE---------QAKYQRIPTDEYEARTLASADLDG 265

  Fly   211 LRSHRSDDPRALRRHKIHHSSIKLRELPQITIS----PFTNKKPEVDHSPHEIFVQLDEL-TGVG 270
            ::|||.:|...:|||.:..|:    :...:.||    ..:.:..::|.:|||:||:|:|| ....
Zfish   266 IKSHRFEDVPGVRRHLVRKST----KGQMVHISKDHKERSTRSRKLDRTPHEVFVELNELIMDKN 326

  Fly   271 EDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYR 335
            ::.:|:|||||||:||||||.:|||||||||||||.|||.||:.:..|.|||||::|.||.::::
Zfish   327 QEMQWRETARWIKFEEDVEEETDRWGKPHVASLSFRSLLELRKTIAHGAVLLDLDQKTLPGISHQ 391

  Fly   336 VVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQ 400
            |||||:|.|.|...|:.:|:|:|||:|.|.::.       |....|:
Zfish   392 VVEQMIISDQIKAEDRANVLRALLLKHSHPSDE-------KEHITSF------------------ 431

  Fly   401 QAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRR----HSTM-------SYLGN 454
                 |||:                       :|.:..:.|.|.:    |.|:       ..:|:
Zfish   432 -----PRNI-----------------------SAASLGSLISHHQSSSNHLTIPETSVMEPLMGS 468

  Fly   455 LSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLV 519
            ...:.|..:.|    :|..:::.:...|.|.   .|.|:.:||      :|::||..||||.|||
Zfish   469 SRASQDSTVHI----DIDKNEKDSATPIGMH---RSKSKHELK------LLEKIPENAEATVVLV 520

  Fly   520 GAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFH 584
            |:|:||||||:|||||.|.|.:.::.||||||||:||||||.:.::|||::||||||||:::.||
Zfish   521 GSVDFLEQPTMAFVRLQEAVELDSVLEVPVPVRFLFVLLGPPSTNMDYHQIGRSISTLMSDKQFH 585

  Fly   585 SIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQ----VKR 645
            ..||.||||:|||:|||.|||.||||||......|||              |.:...|    .||
Zfish   586 EAAYLADDRQDLLNAINGFLDCSIVLPPSELGGEDLL--------------RSVAHFQREMLRKR 636

  Fly   646 DSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRN 710
            :.:.:.:...|.|:|.||:.|.|                     ..|.:..||::||||:|||..
Zfish   637 EEQGVALMAKEPKSLQEKEALLA---------------------PFKPEDDPLKRTGRLFGGLIR 680

  Fly   711 DLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGI 775
            |.:||.|.|.||..|.||.:.:||.||:|||.||.|||||||:..||...:|:||.:::..:.|:
Zfish   681 DAQRRYPKYISDFRDALNPQCMAAVIFIYFAALSPAITFGGLLGEKTEGLLGVSELIVATCVQGV 745

  Fly   776 VFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVR 840
            :|..|..|||:|:|.:||:|:|:||...||..:..::|:.||::|.|||||.:.:.|||||..||
Zfish   746 LFCLLGAQPLLIVGFSGPILVFEEAFFSFCKGNNMEYLTGRVWIGFWLIIIVVLMVAFEGSFMVR 810

  Fly   841 LLTRFTQEIFSALITLIYIVETFMKLISIYRENPL------LSDYNLPPPTLVAHEHATNESLLN 899
            .::||||||||.||:||:|.|||.||..|::|:||      |.|         ....:.|.|:..
Zfish   811 FVSRFTQEIFSFLISLIFIYETFSKLAKIFQEHPLQRCSAVLVD---------VRNSSLNSSMDE 866

  Fly   900 ATAS---VTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFL 961
            .|.|   ||.:.:|.|:.:      :|       :|||||...:|...||::|:||:.|:||.|.
Zfish   867 VTESPLAVTNSSSQEVLKV------VG-------EPNTALLSLVLMSGTFLIAFYLRKFKNSAFF 918

  Fly   962 GRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI---GFDTS-STW 1022
            ....||.:|||||||:|.|.|||||.|...||:||.||.|.|.:.|.||||.:   |.|.. ..|
Zfish   919 PGRLRRVIGDFGVPIAILIMVLVDYSVKDTYTQKLSVPRGFSVTSPDKRGWIVNPLGSDGQFPIW 983

  Fly  1023 IPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAA 1087
            :.||.::|||||:||||||:||:.|||.|.:|.|.||||.|.|::|:..|.....:||:||..||
Zfish   984 MMFASILPALLVFILIFMETQITTLIVSKKERMLVKGSGFHLDLLLIVTLGGTSALFGLPWMAAA 1048

  Fly  1088 TVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVF 1152
            |||||||.:::|:||:..|||:.|||.:|||||::|..|.:::|||:::..|||.||:|||||:|
Zfish  1049 TVRSVTHANALTVMSKAVAPGDKPRIQEVKEQRVTGLLVAILVGLSIVIGDLLRQIPIAVLFGIF 1113

  Fly  1153 LYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSL 1217
            |||||.|::|:|:.|||.|..||.|::|..:||:::|..::||||.|||:||.:||:|.|:..||
Zfish  1114 LYMGVMSLNGIQMTERILLLLMPPKYHPDHTYVRKVRTLRMHLFTAIQVVCLAVLWAVMSTVASL 1178

  Fly  1218 AFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKNDDDEPDFYEQ 1263
            ||||.|||.||::. .|.:::...|||.||.      ||.||.|.|:
Zfish  1179 AFPFVLIMTVPVKMFLLPRIFSNREMQCLDA------DDAEPTFDEK 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	450/1034 (44%)
		Band_3_cyto	287..618	CDD:284893	140/341 (41%)
		HCO3_cotransp	698..1199	CDD:279322	247/513 (48%)
slc4a2b	NP_001107912.1	ae	315..1231	CDD:273290	450/1034 (44%)
		Band_3_cyto	343..615	CDD:284893	140/337 (42%)
		HCO3_cotransp	668..1160	CDD:279322	247/513 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575045
Domainoid	1	1.000	470	1.000	Domainoid score	I430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128699
Inparanoid	1	1.050	820	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG48894
OrthoDB	1	1.010	-	-		D173913at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm24637
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	1	1.100	-	-	O	PTHR11453
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940