DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ae2 and slc4a4a

DIOPT Version :9

Sequence 1:NP_648357.1 Gene:Ae2 / 39147 FlyBaseID:FBgn0036043 Length:1268 Species:Drosophila melanogaster
Sequence 2:XP_009300017.1 Gene:slc4a4a / 568631 ZFINID:ZDB-GENE-060526-274 Length:1146 Species:Danio rerio


Alignment Length:1285 Identity:417/1285 - (32%)
Similarity:645/1285 - (50%) Gaps:257/1285 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 IGSRKKNSIRTND-------LNIEEDSE------YESQTEPLNNAQNYDDIPED------FPLVS 113
            :.|..:|:::.|:       |::||..|      |..:.|        |:...|      .||..
Zfish     1 MASSSRNTLQVNEPRRYGSTLSLEEKCEQSFFLFYYYRVE--------DEAVLDRGASLLKPLCD 57

  Fly   114 ERAGHGDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVE 178
            :....|.|:        :..|  ..:|.|.              |||.||    :|:.||:|.  
Zfish    58 QEEVEGHHT--------IYIG--VHVPKSY--------------RRRRRH----RRRTSHKDR-- 92

  Fly   179 PKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITIS 243
             |.|:.||                         .|.|||   |....:..:|.:|....|.....
Zfish    93 -KEKVSEN-------------------------TSDRSD---AENNEEASNSILKPLISPAAERI 128

  Fly   244 PFTNKKPEVDHSPHEIFVQLDELTGV-GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHS 307
            .|...:.:...:|.::|.:||||..| |::.||||||||||:||.||:|.:||.|||||:||.||
Zfish   129 RFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHS 193

  Fly   308 LLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVL 372
            |..||.|:|.|.::|||....||.|...:.:..:...|:..:.|..||.:||.:|||.       
Zfish   194 LFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRHQ------- 251

  Fly   373 PFTKRKY--------NSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTS-------SA 422
              ||:..        .:.:|...|:...|:|..|.:.:.|            |:|:       ..
Zfish   252 --TKKSNLRSLADIGKTVSSASRLFSTPDNARNPLESSVP------------CLTTRTSEEVLRV 302

  Fly   423 PPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDD 487
            |.:.:|...::.|.|      .|:.|.|.|.::|...:|                ::||      
Zfish   303 PGSPSMGWPSSPTTA------HRNLTSSSLNDISDKPEK----------------DQLK------ 339

  Fly   488 MYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVR 552
                          :..:|::|..|||:.||||.|:||:.|.:|||||.:.|::..|||||||.|
Zfish   340 --------------NKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTR 390

  Fly   553 FMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDR 617
            |:|:||||:.....|||:||:|:|||::|.||.|||||.||:|||:.|:||||:.||||||.|| 
Zfish   391 FLFILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWD- 454

  Fly   618 HDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFT--IGGGDGGG 680
                |...::..|....:.|.|.:....||..:.                  |.|  .||..|||
Zfish   455 ----PAIRIEPPKSLPSSDKRKNMYAGGDSTQMN------------------GDTPHSGGHGGGG 497

  Fly   681 DGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLST 745
            ....|:           |:|||:..|||..|:||::|.:.||..|.|:.::|:|.:|:|...::.
Zfish   498 HAVGDE-----------LKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTN 551

  Fly   746 AITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEF 810
            |||||||:...|.:..|:.|:.:..::.|.||..|:.|||:|:.:|||:|:|:..|..|..:::|
Zfish   552 AITFGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDF 616

  Fly   811 DFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPL 875
            |:|..|:::|:|.....|.:.|.:.|..|:..||||:|.||:||:.|:|.:.|.|::.:....|:
Zfish   617 DYLEFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPI 681

  Fly   876 LSDYNLPPPT-----LVAHEHATNESL----LNATASVTTN-ITQMVMNISTTAMPIGPPPLPKN 930
            .||:.:...|     .:|...|.:..:    |::|...|.| .|...||.:.::       |.|.
Zfish   682 NSDFKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSS-------LSKK 739

  Fly   931 Q----------------PNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIA 979
            :                |:..|...||...|:..:..||.|:.|.|.....|:.:.||.:.::|.
Zfish   740 ECLKYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFPTTVRKLISDFAIILAIL 804

  Fly   980 IFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQ 1043
            ||..||.|| .|.|.||:||....|:.|: |||:: .|..:..|:.....:|||||.||:||:.|
Zfish   805 IFCGVDALV-GVETPKLIVPSEFKPTSPN-RGWFVPPFGGNPWWVYLGASVPALLVTILLFMDQQ 867

  Fly  1044 ISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPG 1108
            |:.:||::.:..||||:|.|.|:..:.:|...|...|:||:.||||.|:.|:.|:.:.:.|.|||
Zfish   868 ITAVIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPG 932

  Fly  1109 ESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYF 1173
            |.|:.:.|:|||::|..|.::.|:||.|:|:|:.|||.||:||||||||||::|||..:|::|..
Zfish   933 EQPKFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLL 997

  Fly  1174 MPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYK 1238
            ||.||.|...|::.:...|:||||.:|:|||.|||.:||:..::.||..::.:|.:|:.|..::.
Zfish   998 MPAKHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFS 1062

  Fly  1239 PEEMQALDG----SEMKKNDD----------------DEPDFYEQTNIPA 1268
            ..::..||.    .:.||.:|                ::.|:....|:|:
Zfish  1063 QHDLSFLDDVIPEKDKKKKEDEKKKKKKKQGSIDSDMEDSDYPYNENVPS 1112

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ae2NP_648357.1 ae 260..1267 CDD:273290 375/1071 (35%)
Band_3_cyto 287..618 CDD:284893 125/345 (36%)
HCO3_cotransp 698..1199 CDD:279322 196/527 (37%)
slc4a4aXP_009300017.1 ae 145..1070 CDD:273290 368/1030 (36%)
Band_3_cyto 173..455 CDD:284893 125/349 (36%)
HCO3_cotransp 504..1023 CDD:279322 196/527 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170575036
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265068at2759
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100185
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X102
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.650

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