Protein Alignment Ae2 and slc4a4a

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_073806935.1
• Gene: slc4a4a / 568631
• ZFINID: ZDB-GENE-060526-274
• Length: 1165
• Species: Danio rerio
• Alignment Length: 1255
• Identity: 417/1255 - (33%)
• Similarity: 642/1255 - (51%)
• Gaps: 232/1255 - (18%)

  Fly    68 IGSRKKNSIRTND-------LNIEEDSE------YESQTEPLNNAQNYDDIPED------FPLVS 113
            :.|..:|:::.|:       |::||..|      |..:.|        |:...|      .||..
Zfish     1 MASSSRNTLQVNEPRRYGSTLSLEEKCEQSFFLFYYYRVE--------DEAVLDRGASLLKPLCD 57

  Fly   114 ERAGHGDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVE 178
            :....|.|:        :..|  ..:|.|.              |||.||    :|:.||:|.
Zfish    58 QEEVEGHHT--------IYIG--VHVPKSY--------------RRRRRH----RRRTSHKDR-- 92

  Fly   179 PKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITIS 243
             |.|:.||                         .|.|||   |....:..:|.:|....|.....
Zfish    93 -KEKVSEN-------------------------TSDRSD---AENNEEASNSILKPLISPAAERI 128

  Fly   244 PFTNKKPEVDHSPHEIFVQLDELTGV-GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHS 307
            .|...:.:...:|.::|.:||||..| |::.||||||||||:||.||:|.:||.|||||:||.||
Zfish   129 RFILGEDDDSPAPPQLFTELDELLSVDGQEMEWKETARWIKFEEKVEKGGERWSKPHVATLSLHS 193

  Fly   308 LLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVL 372
            |..||.|:|.|.::|||....||.|...:.:..:...|:..:.|..||.:||.:|||
Zfish   194 LFELRTCIEKGTIMLDLEASTLPGVVEMITDSQIESGLLKADLKEKVMYTLLRKHRH-------- 250

  Fly   373 PFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSI-----CVTS-------SAPPT 425
               :.|.::..||..:.....||.:.:.    .|.|...||..:     |:|:       .||.:
Zfish   251 ---QTKKSNLRSLADIGKTVSSASRLFS----TPDNGNTARNPLESSVPCLTTRTSEEVLRAPGS 308

  Fly   426 AAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYS 490
            .:|...::.|.|      .|:.|.|.|.::|...:|                ::||
Zfish   309 PSMGWPSSPTTA------HRNLTSSSLNDISDKPEK----------------DQLK--------- 342

  Fly   491 SSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMF 555
                       :..:|::|..|||:.||||.|:||:.|.:|||||.:.|::..|||||||.||:|
Zfish   343 -----------NKFMKKLPRDAEASNVLVGEVDFLDSPFVAFVRLQQAVMLGALTEVPVPTRFLF 396

  Fly   556 VLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDL 620
            :||||:.....|||:||:|:|||::|.||.|||||.||:|||:.|:||||:.||||||.||
Zfish   397 ILLGPKGKAKSYHEIGRAIATLMSDEVFHEIAYKAKDRQDLLAGIDEFLDEVIVLPPGEWD---- 457

  Fly   621 LPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFT--IGGGDGGGDGD 683
             |...::..|....:.|.|.:....||..:.                  |.|  .||..|||...
Zfish   458 -PAIRIEPPKSLPSSDKRKNMYAGGDSTQMN------------------GDTPHSGGHGGGGHAV 503

  Fly   684 SDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAIT 748
            .|:           |:|||:..|||..|:||::|.:.||..|.|:.::|:|.:|:|...::.|||
Zfish   504 GDE-----------LKKTGKFCGGLILDVKRKVPFFFSDFYDSLHIQSLSAILFIYLGTVTNAIT 557

  Fly   749 FGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFL 813
            ||||:...|.:..|:.|:.:..::.|.||..|:.|||:|:.:|||:|:|:..|..|..:::||:|
Zfish   558 FGGLLGDATENMQGVLESFLGTAVTGAVFCLLAGQPLIILSSTGPVLVFERLLFNFSRENDFDYL 622

  Fly   814 SLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSD 878
            ..|:::|:|.....|.:.|.:.|..|:..||||:|.||:||:.|:|.:.|.|::.:....|:.||
Zfish   623 EFRLWIGLWSAFFCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMLKLAHYYPINSD 687

  Fly   879 YNLPPPT-----LVAHEHATNESL----LNATASVTTN-ITQMVMNISTTAMPIGPPPLPKNQ-- 931
            :.:...|     .:|...|.:..:    |::|...|.| .|...||.:.::       |.|.:
Zfish   688 FKIDYVTQYDCMCMAPTDANSSDVYTDPLDSTFVWTVNYTTDPRMNATWSS-------LSKKECL 745

  Fly   932 --------------PNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFV 982
                          |:..|...||...|:..:..||.|:.|.|.....|:.:.||.:.::|.||.
Zfish   746 KYGGELVGKACEFVPDITLMSFILFFGTYTCSMCLKKFKTSPFFPTTVRKLISDFAIILAILIFC 810

  Fly   983 LVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQISE 1046
            .||.|| .|.|.||:||....|:.|: |||:: .|..:..|:..|..:|||||.||:||:.||:.
Zfish   811 GVDALV-GVETPKLIVPSEFKPTSPN-RGWFVPPFGGNPWWVYLAASVPALLVTILLFMDQQITA 873

  Fly  1047 LIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESP 1111
            :||::.:..||||:|.|.|:..:.:|...|...|:||:.||||.|:.|:.|:.:.:.|.||||.|
Zfish   874 VIVNRKEHKLKKGAGYHLDLFWVAVLLAVCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQP 938

  Fly  1112 RIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPV 1176
            :.:.|:|||::|..|.::.|:||.|:|:|:.|||.||:||||||||||::|||..:|::|..||.
Zfish   939 KFLGVREQRVTGVMVFILTGISVFMSPVLKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPA 1003

  Fly  1177 KHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEE 1241
            ||.|...|::.:...|:||||.:|:|||.|||.:||:..::.||..::.:|.:|:.|..::...:
Zfish  1004 KHQPDLIYLRHVPLRKVHLFTFVQLLCLALLWVLKSTVAAIIFPVMILALVAVRKALDYIFSQHD 1068

  Fly  1242 MQALDG----SEMKKNDDDE 1257
            :..||.    .:.||.:|::
Zfish  1069 LSFLDDVIPEKDKKKKEDEK 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	376/1044 (36%)
slc4a4a	XP_073806935.1	None