Protein Alignment Ae2 and slc4a1b

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001161738.1
• Gene: slc4a1b / 561787
• ZFINID: ZDB-GENE-110215-2
• Length: 851
• Species: Danio rerio
• Alignment Length: 1028
• Identity: 366/1028 - (35%)
• Similarity: 550/1028 - (53%)
• Gaps: 228/1028 - (22%)

  Fly   275 WKETARWIKYEE--DVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVV 337
            |:|..||..|||  |||.|  ||...|::.|:|.||:.:||.:.|||::||..||.|.::..::|
Zfish    16 WQEMGRWAGYEETYDVEAG--RWSPSHISYLTFKSLVQIRRTMNTGVMMLDREEKTLSSIIEKIV 78

  Fly   338 EQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQA 402
            :.:|.:..|...|:..|:::|:                                    |:..|..
Zfish    79 DTLVSKKEIQPGDRDKVLQALM------------------------------------HKQSQSV 107

  Fly   403 QPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMP 467
            :..|           :||:
Zfish   108 ETQP-----------LTSN---------------------------------------------- 115

  Fly   468 AAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAF 532
                          ::|:....:..:|...|             .||:.|||||:||||:||:.|
Zfish   116 --------------VEMEKFSVTEKRETADK-------------TEASMVLVGALEFLERPTVVF 153

  Fly   533 VRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLL 597
            |||.:.|::.:..|.||||||:|:|:||....::|||.||:::.|:|::.|:..|::|...::|.
Zfish   154 VRLRDAVVLESALEAPVPVRFIFILIGPTIDGMNYHECGRAMAALLADKVFNQAAFQAQSDRELT 218

  Fly   598 SAINEFLDDSIVLPPGNWDRHDLL----PFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEK 658
            .|:.:|:|..||:||.......||    ||::             |.||.:......|:..|.
Zfish   219 DAVGDFMDCCIVIPPTEIQNESLLTSLIPFQK-------------KLLQERLRPSNPKLRLDV-- 268

  Fly   659 ALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPS---------PLEKTGRLWGGLRNDLKR 714
                                            |.:|||         ||.:||..:||:..|:||
Zfish   269 --------------------------------KPRKPSKSSGPPPEDPLTRTGVPFGGMIRDMKR 301

  Fly   715 RMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGG------LVSAKTNSWIGISETLISCSLV 773
            |...|.||:.|.||.:.|||.||:|||.||.||||||      |::.|.::.:|:||.:||.||:
Zfish   302 RYKHYISDLTDALNAQVLAAIIFIYFAALSPAITFGGLLALTFLIADKVDNMMGVSELMISTSLL 366

  Fly   774 GIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVY 838
            ||:|..::.||:::||.:||||:|:||...||.....:::..||:||:||::|.:.:.|.|||..
Zfish   367 GIIFCLIAAQPVLVIGFSGPLLVFEEAFFNFCKSQGIEYIVGRVWVGIWLVVIVVGIVALEGSFL 431

  Fly   839 VRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNL-------PPPTLVAHEHATNES 896
            ||.::||||||||.||:||:|.|||.||:.|:||:||..:|..       |..::|:::...:
Zfish   432 VRFISRFTQEIFSILISLIFIYETFAKLLKIFREHPLTLNYEHLNTSVEDPWHSIVSYQKIFD-- 494

  Fly   897 LLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFL 961
              |||.:|:     :|..:...|           .|||||....|....|.:||||::|:|..||
Zfish   495 --NATGNVS-----VVRTVEHQA-----------YPNTALLSMCLMFGCFSIAYYLRMFKNGKFL 541

  Fly   962 GRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG----FDTSSTW 1022
            ....||.||||||||:|.:...:|..:...||:|||||:||..|:||.|||.|.    ..:...|
Zfish   542 PGKIRRLLGDFGVPIAIFLMAAIDINIEDTYTQKLVVPKGLQVSNPSMRGWLINPFGEHKSFPVW 606

  Fly  1023 IPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAA 1087
            :.||.::||:||:||||:||||:.|||.||:|.:.||||.|.|:::|..:......||:||..||
Zfish   607 MMFASIVPAILVFILIFLESQITTLIVSKPERKMVKGSGFHMDLLILVSMGGLSAFFGIPWLSAA 671

  Fly  1088 TVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVF 1152
            |||||:|.:::|:||:    |..|.|..|.|||:||..|.|::|||:||.|:|::||:..|||:|
Zfish   672 TVRSVSHANALTVMSK----GPKPEIEKVLEQRVSGVVVALLVGLSILMEPILKMIPITALFGIF 732

  Fly  1153 LYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSL 1217
            ||||:.|:||:||::|:.|..:|.|::|...|..|:...|:|:||.||::||.:||.||||..||
Zfish   733 LYMGITSLSGIQLWDRMLLLLIPKKYHPNEPYATRVSTSKMHVFTAIQMVCLAVLWIVKSSPASL 797

  Fly  1218 AFPFFLIMMVPIRQNLT-KLYKPEEMQALDGSEMKKNDDDEP--DFYEQTNIP 1267
            |.||.||:.:|:|..:| :|:..::|:.|||.:.|...::||  |.|.:|.:|
Zfish   798 ALPFVLILTIPLRMFMTGRLFTEQDMKFLDGDDSKATFEEEPGVDVYSETQMP 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	365/1026 (36%)
slc4a1b	NP_001161738.1	Band_3_cyto	2..850	CDD:452680	365/1026 (36%)