DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ae2 and slc4a5a

DIOPT Version :9

Sequence 1:NP_648357.1 Gene:Ae2 / 39147 FlyBaseID:FBgn0036043 Length:1268 Species:Drosophila melanogaster
Sequence 2:XP_021332155.1 Gene:slc4a5a / 559268 ZFINID:ZDB-GENE-060531-64 Length:1145 Species:Danio rerio


Alignment Length:1177 Identity:397/1177 - (33%)
Similarity:610/1177 - (51%) Gaps:206/1177 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 KKKIPPSLSYDEQ------PTDQSHERKRRRS---------------RHQYYRQRKFSHQDSVEP 179
            |..:||:   |.|      |..:.:.|||||.               ||.::|...:...|  ..
Zfish    23 KSVLPPT---DHQSIYIGVPVPRGYRRKRRRRRSSMSSRDADVDRRLRHDHHRHEHYECDD--RD 82

  Fly   180 KNKLEENGDAGARRISVQPEDTALEEA------DLNELRSHRSDDPRALRRHKIHHSSIKLRELP 238
            :..||..|               |::|      |:|     |:..|.|.|...|.....:....|
Zfish    83 RYDLEAGG---------------LDQAEHNLPPDIN-----RTMSPAAERLRYILGDDEETMPTP 127

  Fly   239 QITISPFTNKKPEVDHSPHEIFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASL 303
                               .:|.::|.|...|::.||:|:|||:|:||.||||.:||.||||::|
Zfish   128 -------------------TLFTEMDTLQHEGDELEWRESARWVKFEEKVEEGGERWSKPHVSTL 173

  Fly   304 SFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLI--DINDKPSVMRSLLLRHRHVN 366
            |.|||..||.||:||.|||||....||.:...::::.|.|.||  ::.||.|.:  ||.:|||  
Zfish   174 SLHSLFELRTCLQTGTVLLDLEGYSLPQIVDDIIDRQVEEGLIGPELRDKISFV--LLRKHRH-- 234

  Fly   367 EHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNV 431
                                             |..:|..|:||...:|....:.:|        
Zfish   235 ---------------------------------QTKKPIHRSLADLGKSGSGGTRSP-------- 258

  Fly   432 ATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDL 496
             ..|.||.|.:..|           .|:|.:.|  .||..|..:.:...  .|.|...:.|.:.|
Zfish   259 -ARTPAAQAANFNR-----------STEDLRTK--QAANYGRLRHAQSR--SMNDIADTPSTDQL 307

  Fly   497 KKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPR 561
            |    :..:|:||..|||:.||||.|:|||:|.:||||||:...:..|||||||.||:||||||.
Zfish   308 K----NKFMKKIPRDAEASNVLVGEVDFLEKPFVAFVRLSQATTLGGLTEVPVPTRFLFVLLGPP 368

  Fly   562 NFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEEL 626
            .....|:|:||:|:|||.::.|..:||||.||:||::.|:||||:.||||||.||          
Zfish   369 GKAKSYNEIGRAIATLMVDDLFSDVAYKARDREDLIAGIDEFLDEVIVLPPGEWD---------- 423

  Fly   627 KAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRK 691
                     .||:....|:..     ..|:.|::.....||.:..|.|||     |..::|    
Zfish   424 ---------PKIRIEPPKKTP-----SADKRKSVFSLNELGQMNGTAGGG-----GPIEED---- 465

  Fly   692 KKKPSP------LEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFG 750
            ::.|.|      |..|||..|||..|:||::|.|.||..:|.:.::::|.:|:|..|::.|||||
Zfish   466 EEMPVPHELGEELAYTGRFCGGLFLDMKRKLPWYPSDFYEGFHIQSISAVLFIYLGCITNAITFG 530

  Fly   751 GLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSL 815
            ||:...|:::.|:.|:.:..:|.|.||.....|||:|:.:|||:|:|::.|..|...:..|::.|
Zfish   531 GLLGDATDNYQGVMESFLGTALAGTVFCVFGGQPLIILSSTGPILIFEKLLYEFSKNNAIDYMEL 595

  Fly   816 RVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYN 880
            |:::|:...|....:.|.:.|..::.:||||:|.||:||:.|:|.:...|::..::..|:.:|:.
Zfish   596 RLWIGIHSCIQCFILVATDASYIIKYMTRFTEEGFSSLISFIFISDAIKKMVGSFKYYPINTDFK 660

  Fly   881 ------------LPPPTLVAHEHATNESLL---NATASVTTNITQMVMNISTTAMPIGPPPLPKN 930
                        .|.|..|    ..|.|.|   |.||...|.:::... :......:|..  .|.
Zfish   661 PDYVTAYKCECVAPDPIPV----PDNTSALFGFNITALDWTQLSKKEC-VKYGGSLVGQS--CKY 718

  Fly   931 QPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEK 995
            .|:.||...||...|:.:...||.|:.|.:.....|:.:.||.:.:||..||.:|.|: .:.|.|
Zfish   719 VPDLALMSFILFCGTYTMTVTLKKFKFSRYFPTKLRKLISDFSIFMSIMTFVGLDMLI-GLKTPK 782

  Fly   996 LVVPEGLSPSDPSKRGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKG 1059
            |:||....|:.|. |||:: .|..:..|:..|..:|||||.|||||:.|||.:||::.:..||||
Zfish   783 LIVPTEFKPTRPD-RGWFVMPFGKNPWWVYLASFVPALLVTILIFMDQQISAVIVNRKENKLKKG 846

  Fly  1060 SGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGF 1124
            .|.|.|::.:.:|..||...|:||:.||||.|:.|:.|:.:.|.:.||||.|:.:.|:||||:|.
Zfish   847 CGYHLDLLWVGVLMAACSFMGLPWYVAATVISIAHIDSLKMESESSAPGEQPQFLGVREQRLTGI 911

  Fly  1125 FVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLR 1189
            .|.::.|:|:.:||:|:.|||.||:||||||||||:||:|.::||:|..||.||.|..||::.:.
Zfish   912 LVFVLTGVSIFLAPILQFIPMPVLYGVFLYMGVASLSGIQFWDRIKLIMMPAKHQPDFSYLRHVP 976

  Fly  1190 PWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEM 1250
            ..::||||.:|::||.:||.:||:..::.||..::.::.:|:.|..::...::..||.    .|.
Zfish   977 LRRVHLFTLVQIVCLAVLWILKSTFLAIIFPVMILGLMVVRKMLDMVFSQHDLAWLDDILPEKEK 1041

  Fly  1251 KKNDDDE 1257
            ||.||::
Zfish  1042 KKKDDEK 1048

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ae2NP_648357.1 ae 260..1267 CDD:273290 369/1026 (36%)
Band_3_cyto 287..618 CDD:284893 129/332 (39%)
HCO3_cotransp 698..1199 CDD:279322 194/516 (38%)
slc4a5aXP_021332155.1 Band_3_cyto 130..1033 CDD:331698 362/1009 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170575027
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D265068at2759
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100185
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X102
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.650

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