Protein Alignment Ae2 and slc4a8

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_685666.5
• Gene: slc4a8 / 557494
• ZFINID: ZDB-GENE-131119-88
• Length: 1105
• Species: Danio rerio
• Alignment Length: 1155
• Identity: 400/1155 - (34%)
• Similarity: 588/1155 - (50%)
• Gaps: 205/1155 - (17%)

  Fly   185 ENGDAGARRISVQPEDTALEE-----ADLN------ELRSHRS---------DDPRALRRHKIHH 229
            ||.|..:.....:|.:.|:.:     :.||      ||..||:         |.| :.|.|:.|.
Zfish     4 ENSDQESMLSYQRPGEEAVVDHGGTSSVLNIHYEKEELEGHRTLFVGVRMPMDRP-SHRHHRPHS 67

  Fly   230 SSIKLR-----------------------ELPQITISPFTNKKPEVDHSPHEIFVQLDEL-TGVG 270
            |..:.|                       :.|...:......:.:.:|..||:|.:|||: ...|
Zfish    68 SRHRRRSDRMRAGGSAQDDDNSESTPGAHDTPSQRVRFILGTEEDEEHVAHELFTELDEICVKEG 132

  Fly   271 EDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYR 335
            :|.||||||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.||||:....:..:|..
Zfish   133 KDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCIINGTVLLDMKAGSIEEIADL 197

  Fly   336 VVEQMVIEDLIDINDKPSVMRSLLLRHRHVNE--HQGVLPFTKRKYNSYTSLQFLWMGADSAHQP 398
            |:|:......:|.:.:..|..:||.||.|.|:  ...:||..|
Zfish   198 VLEKQETPHELDDSVRMKVREALLKRHHHQNDKKRNNLLPMVK---------------------- 240

  Fly   399 YQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKI 463
                                              |.|.|     :||||...::       ||
Zfish   241 ----------------------------------TLTEA-----NRRHSETHFM-------DK-- 257

  Fly   464 KIMPAAEIGGSKRSNELKIDMKDDMYSS-SQEDLKKLQNDT-ILKRIPAGAEATTVLVGAVEFLE 526
                 ..:..|.:......|:|:...|. .|.||.|:  || .:|:||.||||:.||||.::|||
Zfish   258 -----TGLATSPQPPTTSTDIKNGATSEIGQMDLSKV--DTHFMKKIPTGAEASNVLVGELDFLE 315

  Fly   527 QPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKAD 591
            :..:||||||..||:..|||||:|.||:|:||||......|||:|||::|:|.:|.||.:||||.
Zfish   316 RSIVAFVRLSPAVLLTGLTEVPIPTRFLFILLGPDGKAQQYHEIGRSMATIMTDEIFHDVAYKAK 380

  Fly   592 DRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKAL--QVKRDSEMIKIGK 654
            ||.|||:.|:||||...|||||.||..              ||....|.:  |.||....:..|
Zfish   381 DRTDLLAGIDEFLDQVTVLPPGEWDPS--------------IRIEPPKCVPSQEKRKMPGVPNG- 430

  Fly   655 DEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMY 719
               .|:..::.|.|                 :.:|.:      |::||||:|||..||||:.|.|
Zfish   431 ---TAVTVEEELHA-----------------EHHGPE------LQRTGRLFGGLILDLKRKAPYY 469

  Fly   720 KSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQP 784
            .||..|||..:.:|:.:|:|.||:|..||||||:...|...|...|:|:..|:.|:.:...:.||
Zfish   470 LSDFKDGLTLQCVASFLFLYCACMSPVITFGGLLGEATEGQISAIESLLGASMTGVAYSLFAGQP 534

  Fly   785 LVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEI 849
            |.|:|:|||:|:|::.|..||..::..:||||..:|:|...:.|.:.|.:.|..|..:||||:|.
Zfish   535 LTILGSTGPVLVFEKILFKFCKDYDLSYLSLRTCIGLWTAFLCLLLVATDASSLVCYITRFTEEA 599

  Fly   850 FSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMN 914
            |:|||.||:|.|...||..:....|:....:|...||.....|..::..|.|..|...     .|
Zfish   600 FAALICLIFIYEALEKLFYLGELYPINRHSDLDKLTLAYCRCAEPDNPSNKTLEVWNQ-----RN 659

  Fly   915 ISTTAMP----------------IGPP-----PLPKNQPNTALFCTILTLATFVVAYYLKLFRNS 958
            |:.:|:|                |||.     |.   .|:...:.:||...||:::.:||.|:.|
Zfish   660 ITASAVPWTNLTVTECLDLQGQFIGPSCGHHGPY---TPDVLFWSSILFFGTFLMSSFLKQFKAS 721

  Fly   959 HFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTW 1022
            .:.....|..:.||.|.::|...||:||:: .|.::||.||....|: ...|||.:. ...:..|
Zfish   722 RYFPTRVRSMISDFAVFLTIVFMVLIDYII-GVPSQKLQVPSKFKPT-RDDRGWVMNPIGRNPWW 784

  Fly  1023 IPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAA 1087
            ...|.:|||||..|||||:.||:.:|:::.:..|.||.|.|.|::::.::...|.:.|:||..||
Zfish   785 TVLAALIPALLCTILIFMDQQITAVIINRKEHKLVKGCGYHLDLLMVGVMLAVCSMLGLPWFVAA 849

  Fly  1088 TVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVF 1152
            ||.|::||:|:.:.|.:.||||.||.:.::||||:|.|:.|::|.||.|..||:.|||.||:|||
Zfish   850 TVLSISHVNSLKLESESSAPGEQPRFLGIQEQRLTGLFIFLLMGCSVFMTGLLQFIPMPVLYGVF 914

  Fly  1153 LYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSL 1217
            |||||:|:.|:|||:|::|:.||.||.|...|::.:...|:||||..|:.||||||.:|.|..::
Zfish   915 LYMGVSSLKGIQLFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLTQLTCLVLLWVIKHSPAAI 979

  Fly  1218 AFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPDFYEQ 1263
            .||..::.:|.||:.|...:...|:..||.    :..||.|||.....||
Zfish   980 VFPMMVLALVFIRKLLDFCFSKRELSYLDDLMPENRKKKLDDDSKKAEEQ 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	378/1037 (36%)
		Band_3_cyto	287..618	CDD:284893	123/334 (37%)
		HCO3_cotransp	698..1199	CDD:279322	202/522 (39%)
slc4a8	XP_685666.5	ae	121..1008	CDD:273290	369/1014 (36%)
		Band_3_cyto	149..407	CDD:284893	123/334 (37%)
		HCO3_cotransp	448..960	CDD:279322	201/521 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.680