Protein Alignment Ae2 and Slc4a4

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_017176484.1
• Gene: Slc4a4 / 54403
• MGIID: 1927555
• Length: 1131
• Species: Mus musculus
• Alignment Length: 1194
• Identity: 412/1194 - (34%)
• Similarity: 623/1194 - (52%)
• Gaps: 212/1194 - (17%)

  Fly   146 DEQPTDQSH---------ERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPEDT 201
            ||:..:..|         :..|||.||    :||..|::..| |.::.||          ..:.:
Mouse    24 DEEEVEGHHTIYIGVHVPKSYRRRRRH----KRKAGHKEKKE-KERISEN----------YSDKS 73

  Fly   202 ALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNK----KPEVDHS--PHEIF 260
            .:|.||                    ..||..|:.|    |||...:    ..|.|.|  |.::|
Mouse    74 DVENAD--------------------ESSSSILKPL----ISPAAERIRFILGEEDDSPAPPQLF 114

  Fly   261 VQLDELTGV-GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDL 324
            .:||||..| |::.||||||||||:||.||:|.:||.|||||:||.|||..||.|:|.|.::||.
Mouse   115 TELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDR 179

  Fly   325 NEKDLPAVAYRVVEQMVIEDLI--DINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKY-------- 379
            ....||.:...:.:..:...|:  |:.||  |..:||.:|||.         ||:..
Mouse   180 EASSLPQLVEMIADHQIETGLLKPDLKDK--VTYTLLRKHRHQ---------TKKSNLRSLADIG 233

  Fly   380 NSYTSLQFLWMGADSAHQPYQQAQPPPRNLA-----KARRSICVTSSAPPTAAMLNVATATAAAA 439
            .:.:|...::...|:|..|.:.:.|...|..     :.||:        |:...|       ::.
Mouse   234 KTVSSASRMFSNPDNARSPLENSVPCLANRTLDDDPRVRRT--------PSVGWL-------SSP 283

  Fly   440 AIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTI 504
            |:.| |:.|.|.|.::|...:|                ::||                    :..
Mouse   284 AMTH-RNLTSSSLNDISDKPEK----------------DQLK--------------------NKF 311

  Fly   505 LKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHE 569
            :|::|..|||:.||||.|:||:.|.||||||.:.|::..|||||||.||:|:||||:.....|||
Mouse   312 MKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHE 376

  Fly   570 VGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIR 634
            :||:|:|||::|.||.|||||.||.||::.|:||||:.||||||.||     |...::..|....
Mouse   377 IGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWD-----PTIRIEPPKSLPS 436

  Fly   635 TRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLE 699
            :.|.|  .:....|.:::..|....              ||..|||.||.::           |:
Mouse   437 SDKRK--NMYSGGENVQMNGDTPHD--------------GGHGGGGHGDCEE-----------LQ 474

  Fly   700 KTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGIS 764
            :|||..|||..|:||:.|.:.||..|.||.:.|:|.:|:|.|.::.|||||||:...|::..|:.
Mouse   475 RTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVL 539

  Fly   765 ETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALT 829
            |:.:..::.|.:|...:.|||.|:.:|||:|:|:..|..|...|.||:|..|:::|:|...:.|.
Mouse   540 ESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFMCLV 604

  Fly   830 VSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSD----YN-------LPP 883
            :.|.:.|..|:..||||:|.||:||:.|:|.:.|.|:|.:....|:.||    ||       |||
Mouse   605 LVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFKVGYNTHFSCACLPP 669

  Fly   884 PTLVAHEHATNESLLNATASVTTNITQMVMNIS--------TTAMPIGPPPLPKN---QPNTALF 937
            ..:  :...:|::.|......|.:.|.|..|::        ...:..|...:..|   .|:..|.
Mouse   670 DPV--NLSVSNDTTLAPEDLPTISSTDMYHNVTFDWAYLSKKECVKYGGKLVGNNCDFVPDITLM 732

  Fly   938 CTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGL 1002
            ..||.|.|:..:..:|.|:.|.:....||:.:.||.:.:||.||.::|.|| .|.|.||:||...
Mouse   733 SFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALV-GVDTPKLIVPSEF 796

  Fly  1003 SPSDPSKRGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDI 1066
            .|:.|: |||:: .|..:..|:..|..||||||.|||||:.||:.:||::.:..||||:|.|.|:
Mouse   797 KPTSPN-RGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDL 860

  Fly  1067 VLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIG 1131
            ..:.:|...|....:||:.||||.|:.|:.|:.:.:.|.||||.|:.:.|:|||::|..|.::.|
Mouse   861 FWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTG 925

  Fly  1132 LSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLF 1196
            |||.|||:|:.|||.||:||||||||||::|||..:|::|..||:||.|...|::.:...::|||
Mouse   926 LSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLF 990

  Fly  1197 TTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG-----------SEM 1250
            |.:|||||.|||.:||:..::.||..::.:|.:|:.:..|:...::..||.           .|.
Mouse   991 TFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEK 1055

  Fly  1251 KK---------NDDDEPDFYEQTN 1265
            ||         ::|||.|....:|
Mouse  1056 KKKKKKGSLDSDNDDEKDPQHSSN 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	383/1065 (36%)
		Band_3_cyto	287..618	CDD:284893	124/345 (36%)
		HCO3_cotransp	698..1199	CDD:279322	202/523 (39%)
Slc4a4	XP_017176484.1	Band_3_cyto	114..1040	CDD:391624	373/1024 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832142
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650