Protein Alignment Ae2 and Slc4a8

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001401877.1
• Gene: Slc4a8 / 315311
• RGDID: 735164
• Length: 1092
• Species: Rattus norvegicus
• Alignment Length: 1143
• Identity: 381/1143 - (33%)
• Similarity: 580/1143 - (50%)
• Gaps: 192/1143 - (16%)

  Fly   179 PKNKLEENGDAGARRISVQPEDTALEEA-----------DLNELRSHRS--------DDPRALRR 224
            |....|.:|....:|    |::.|:.:.           :..||..||:        ...::.|.
  Rat     2 PAGSNEPDGVLSYQR----PDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRH 62

  Fly   225 HKIHHSSIKLR-------------------ELPQITISPFTNKKPEVDHSPHEIFVQLDEL-TGV 269
            |:.|....:.|                   :.|...:......:.:.:|.|||:|.:|||: ...
  Rat    63 HRTHGQKHRRRGGRGKGASQGEEGLEASAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKE 127

  Fly   270 GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAY 334
            ||:.||||||||:|:|||||:|.:||.||:||:||.|||..||.||..|.||||:....:..::.
  Rat   128 GEEAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISD 192

  Fly   335 RVVEQMVIEDLIDIND--KPSVMRSLLLRHRHVNE--HQGVLPFTKRKYNSYTSLQFLWMGADSA 395
            .:::|.  |.|.|::|  :..|..:||.:|.|.||  ...::|..:         .|..:|
  Rat   193 LILDQQ--ELLRDLSDSVRVKVREALLKKHHHQNEKKRNNLIPIVR---------SFAEVG---- 242

  Fly   396 HQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDD 460
                 :.|..|.::.:..:::. ..|||.|                            ||
  Rat   243 -----KKQSDPHSMDRDGQTVS-PQSAPAT----------------------------NL----- 268

  Fly   461 KKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFL 525
                     |:..........:|:       |:.||.      .:|:|||||||:.||||.|:.|
  Rat   269 ---------EVKNGVNCEHSPVDL-------SKADLH------FMKKIPAGAEASNVLVGEVDTL 311

  Fly   526 EQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKA 590
            ::|.:||||||..||:..|||||:|.||:|:||||......|||:|||::|:|.:|.||.:||||
  Rat   312 DRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKA 376

  Fly   591 DDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKD 655
            .:|.|||:.|:||||...|||||.||     |...::..|:                     ...
  Rat   377 KERDDLLAGIDEFLDQVTVLPPGEWD-----PSIRIEPPKN---------------------VPS 415

  Fly   656 EEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYK 720
            :||..:.....|.|........||..|..             ||:||||:|||..|:||:.|.|.
  Rat   416 QEKRKMPGVPNGNICHVEPEPHGGHSGPE-------------LERTGRLFGGLVLDVKRKAPWYW 467

  Fly   721 SDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPL 785
            ||..|.|:.:.||:.:|:|.||:|..||||||:...|...|...|:|...|:.||.:...:.|||
  Rat   468 SDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPL 532

  Fly   786 VIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIF 850
            .|:|:|||:|:|::.|..||..:...:||||..:|:|...:.:.:.|.:.|..|..:||||:|.|
  Rat   533 TILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAF 597

  Fly   851 SALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNAT-------------- 901
            ::||.:|:|.|...|||.:....|:.....|...:|.....|..|:..|.|
  Rat   598 ASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCALPENPNNHTLQYWKEHSIPTADV 662

  Fly   902 --ASVTTNITQMVMN--ISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLG 962
              |::|.:..|.:..  |.:.....||     ..|:...:..||..|||:|:..||.|:.|.:..
  Rat   663 NWANLTVSECQEMHGEFIGSACGHHGP-----YTPDVLFWSCILFFATFIVSSTLKTFKTSRYFP 722

  Fly   963 RNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFA 1026
            ...|..:.||.|.::|...|::|:|: .|.:.||.||....|: ...|||:|. ...:..|...|
  Rat   723 TRVRSTVSDFAVFLTIFTMVILDFLI-GVPSPKLQVPSVFKPT-RDDRGWFISPIGPNPWWTVIA 785

  Fly  1027 CVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRS 1091
            .:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::.::...|.:.|:||..||||.|
  Rat   786 AIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLVVAIMLGVCSLMGLPWFVAATVLS 850

  Fly  1092 VTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMG 1156
            :|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|..:|:.|||.||:|||||||
  Rat   851 ITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMG 915

  Fly  1157 VASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPF 1221
            |:|:.|:|.|:|::|:.||.||.|...|::.:...|:||||.:|:.||||||.:|:|..::.||.
  Rat   916 VSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPM 980

  Fly  1222 FLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDD 1255
            .::.:|.:|:.:...:...|:..||.    |:.||.||
  Rat   981 MVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDD 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	362/1024 (35%)
Slc4a8	NP_001401877.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..95		4/39 (10%)
		Band_3_cyto	117..1005	CDD:452680	355/1009 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..263		2/20 (10%)