DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ae2 and Slc4a11

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001101245.1	Gene:	Slc4a11 / 311423	RGDID:	1310188	Length:	862	Species:	Rattus norvegicus

Alignment Length:	690	Identity:	191/690 - (27%)
Similarity:	323/690 - (46%)	Gaps:	88/690 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   607 SIVLPPGNWDRHD--------LLPFEELKAKKDWIRTRKIKALQVKRD-----------SEMIKI 652
            |.::.|.||..:.        :|...::|:.|        .|::|.|.           .:::|.
  Rat   206 SRLVRPQNWGENSCEVRFVILVLAPPKMKSTK--------TAMEVARTFATMFSDITFRQKLLKT 262

  Fly   653 GKDEE--KALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPS-----PLEKTGRLWGGLRN 710
            ..:||  :||:.::.|    .|:......|...|.....|..:.|.     |..|      |:..
  Rat   263 RTEEEFKEALVHQRQL----LTMMMPRAAGHSMSSLHTHRHPRPPKCKDFFPFGK------GIWV 317

  Fly   711 DLKRRMPMYKSDILDGL----NT--ETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLIS 769
            |:.||.|:|..|..||:    .|  :.:..|:|:|||||...|.||.|....||..|.:.:|:..
  Rat   318 DIMRRFPVYPLDFTDGIIGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAG 382

  Fly   770 CSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFE 834
            .|:.|:::...|.|||||:.||.||.::.:.:.|.|..:..||.:...:.|:|........:...
  Rat   383 QSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLN 447

  Fly   835 GSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLN 899
            .|:.:.|..|.|:||.:..|::.::::....::.|:.:......|:....:.:|       |||.
  Rat   448 LSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGHHYHTKRTSSLA-------SLLG 505

  Fly   900 ATASVTTNITQMVMNISTTAMPI------GPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNS 958
            .:.|..|:: ...:|.|..|.||      .|.....||. ||:...::.|.|..:.|.|..|:.|
  Rat   506 ISRSPNTSL-HTALNTSFLASPIEMTTASSPISTHSNQA-TAVLSLLIMLGTLWLGYTLYQFKKS 568

  Fly   959 HFLGRNARRALGDFGVPISIAIFVLV-DYLVPAVYTEKLVVPEGLSPSDPSKRGWYIGFDTSSTW 1022
            .:|....|..|.|..:||::..|.|: .|....:...|.    ..:||:..       |:.:...
  Rat   569 PYLHPCVRETLSDCALPIAVLSFSLISSYGFQEIEMSKF----RYNPSESL-------FEVAQIH 622

  Fly  1023 -IPFACVIPAL----LVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMP 1082
             :.|..:..|:    |:.:|.|:|..:...:|:.|:..|.||:..|||::||.::|....:||:|
  Rat   623 SLSFKAISSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLP 687

  Fly  1083 WHCAATVRSVTHVSSVTIMSRTHAPGE-SPRIVDVKEQRLSGFFVCLMIGLSVLMAPL-LRLIPM 1145
            |..||...|..||.::.::......|. ...||:|||.||:.....:::|||:|:.|. |:.||.
  Rat   688 WIHAAYPHSPLHVRALALVEERVENGHIYETIVNVKETRLTALGASVLVGLSLLLLPFPLQWIPK 752

  Fly  1146 AVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSV 1210
            .||:|:|||:.:.|:.|.|||.|:.|.......||||.|::|:...|:|.||.:|:|.|:||.:.
  Rat   753 PVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAF 817

  Fly  1211 KSSQ---FSLAFPFFLIMMVPIRQN-LTKLYKPEEMQALD 1246
            ..|.   ..:.||..:|.|:|||.| |.::.:.:.:..:|
  Rat   818 GMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMD 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	191/690 (28%)
		Band_3_cyto	287..618	CDD:284893	4/10 (40%)
		HCO3_cotransp	698..1199	CDD:279322	153/520 (29%)
Slc4a11	NP_001101245.1	PtsN	<199..277	CDD:224676	15/78 (19%)
Slc4a11	NP_001101245.1	HCO3_cotransp	311..804	CDD:279322	151/518 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820