DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and Slc4a10

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_006234337.1	Gene:	Slc4a10 / 295645	RGDID:	631407	Length:	1148	Species:	Rattus norvegicus

Alignment Length:	1167	Identity:	384/1167 - (32%)
Similarity:	595/1167 - (50%)	Gaps:	203/1167 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 HVQFGGKKKIPPSLSYDEQPTDQSHERKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRI 194
            ||..||:|               ||    ||.||:.::.||...    |..:.||:.|::
  Rat    65 HVPLGGRK---------------SH----RRHRHRGHKHRKRDR----ERDSGLEDGGES----- 101

  Fly   195 SVQPE-DTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISPFTNKKPEVDHSPHE 258
               |. ||..:....  :.....||.                                 :|.||:
  Rat   102 ---PSFDTPSQRVQF--ILGTEDDDE---------------------------------EHIPHD 128

  Fly   259 IFVQLDELT-GVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLL 322
            :|.:|||:. ..|||.||:|||||:|:|||||:|.:||.||:||:||.|||..||.|:..|.|||
  Rat   129 LFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLL 193

  Fly   323 DLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQ--GVLPFTKRKYNSYTSL 385
            |::...|..:|..|::|.|....::.:.:..|..:|:.:|.|.::.:  ..:|..:
  Rat   194 DMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQSQKKLTNRIPIVR--------- 249

  Fly   386 QFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMS 450
            .|..:|         :.|..|.::.|....:....|||..|...|..:          |.:||:.
  Rat   250 SFADIG---------KKQSEPNSMDKNAGQVVSPQSAPACAENKNDVS----------RENSTVD 295

  Fly   451 YLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEAT 515
            :                :..:||.::.:.....||..:........::..:...:|:||.||||:
  Rat   296 F----------------SKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEAS 344

  Fly   516 TVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMAN 580
            .:|||.:|||::..:||||||..||:..|.|||:|.||:|:||||......|||:||||:|||.:
  Rat   345 NILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTD 409

  Fly   581 EHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKR 645
            |.||.:||||.||.||:|.|:||||...|||||.||     |...::..|:       ...|.||
  Rat   410 EVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWD-----PSIRIEPPKN-------VPSQEKR 462

  Fly   646 DSEMIKIGKDEEKALLEKQTLGAIGFTIGGGD--GGGDGDSDDDNGRKKKKPSPLEKTGRLWGGL 708
            .:..:..|....                ||.:  ||..|..             |::|||::|||
  Rat   463 KTPSLPNGTAAH----------------GGPEQHGGHSGPE-------------LQRTGRIFGGL 498

  Fly   709 RNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLV 773
            ..|:||:.|.:.||..|..:.:.||:.:|:|.||:|..||||||:...|...|...|:|...|:.
  Rat   499 ILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMT 563

  Fly   774 GIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVY 838
            ||.:.....|||.|:|:|||:|:|::.|..||.::...:||||..:|:|...:.:.:.|.:.|..
  Rat   564 GIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 628

  Fly   839 VRLLTRFTQEIFSALITLIYIVETFMKL--------ISIYRENPLLSDY--NLPPPTLVAHEHAT 893
            |..:||||:|.|::||.:|:|.|...||        |:::.:..||:.|  |...|    |..:.
  Rat   629 VCYITRFTEEAFASLICIIFIYEALEKLFELSESYPINMHNDLELLTQYSCNCMEP----HSPSN 689

  Fly   894 N------ESLLNATASVTTNITQMVMNIST----------TAMPIGPPPLPKNQPNTALFCTILT 942
            :      ||.::|:..:..|:|     :|.          .|...|.|.:    |:...:..||.
  Rat   690 DTLKEWRESNISASDIIWGNLT-----VSECRSLHGEYVGRACGHGHPYV----PDVLFWSVILF 745

  Fly   943 LATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDP 1007
            .:|..::..||.|:.|.:.....|..:.||.|.::|...||:||.: .:.:.||.||....|: .
  Rat   746 FSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAI-GIPSPKLQVPSVFKPT-R 808

  Fly  1008 SKRGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCL 1071
            ..|||:: ....:..|...|.:|||||..|||||:.||:.:|:::.:..||||.|.|.|::::.:
  Rat   809 DDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAV 873

  Fly  1072 LNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLM 1136
            :...|.|.|:||..||||.|:|||:|:.:.|...||||.|:.:.::|||::|..:.:::|.||.|
  Rat   874 MLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFM 938

  Fly  1137 APLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQV 1201
            ..:|:.|||.||:|||||||.:|:.|:|||:||:|::||.||.|...|::.:...|:||||.||:
  Rat   939 TSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQM 1003

  Fly  1202 LCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDEPD 1259
            .||.|||.:|.|:.::.||..::.:|.:|:.:..|:...|:..||.    |:.||.:|.|.:
  Rat  1004 SCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKE 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	359/1036 (35%)
		Band_3_cyto	287..618	CDD:284893	117/332 (35%)
		HCO3_cotransp	698..1199	CDD:279322	192/527 (36%)
Slc4a10	XP_006234337.1	ae	130..1073	CDD:273290	359/1036 (35%)
		Band_3_cyto	158..447	CDD:284893	117/337 (35%)
		HCO3_cotransp	488..1001	CDD:279322	192/527 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650