DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and Slc4a9

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_690921.2	Gene:	Slc4a9 / 266612	RGDID:	628811	Length:	953	Species:	Rattus norvegicus

Alignment Length:	1029	Identity:	315/1029 - (30%)
Similarity:	497/1029 - (48%)	Gaps:	184/1029 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 IFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLD 323
            :|:||:||.|..:..||:||.||:.:||.::.|:.||..|||.:|:..||..||..|..|:||||
  Rat    52 LFIQLNELLGWPQALEWRETGRWLLFEEKLDIGAGRWSAPHVPTLALPSLQKLRGLLAEGIVLLD 116

  Fly   324 LNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFL 388
            ...:.|    ..:|||:|..:.:....:..:...||.|.:|..:..|:.|
  Rat   117 CPARSL----LELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTTGIRP--------------- 162

  Fly   389 WMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLG 453
                                        |..|:|...|
  Rat   163 ----------------------------CRGSNAFRKA--------------------------- 172

  Fly   454 NLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVL 518
                                                |..::.|.|.|| .:.:::|.||||..||
  Rat   173 ------------------------------------SRDEDTLLKHQN-PLRQKLPPGAEAAAVL 200

  Fly   519 VGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHF 583
            .|.:.|||||..|||||...|::..||||.:|.||..:||||......|||.||:.:.|:::..|
  Rat   201 AGELGFLEQPLAAFVRLQNPVVLEPLTEVVLPSRFFCLLLGPPTLGRSYHETGRAAAVLLSDPQF 265

  Fly   584 HSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSE 648
            .....:|.:..|||:|::.||.:...||||.|||...:|            ..|....|.||..
  Rat   266 QWSVRRASNLHDLLAALDAFLQEVTALPPGRWDRTARIP------------PPKCLPSQHKRFP- 317

  Fly   649 MIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSP-LEKTGRLWGGLRNDL 712
                .|.:|...|.:|:...               :::.:......|.| |::||||:|||..|:
  Rat   318 ----SKLQEVTSLSRQSAAL---------------AENKHHHGPHTPIPELQRTGRLFGGLVQDV 363

  Fly   713 KRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVF 777
            :|:...|.||.||.|:.:..:|.:::|.|.::.|||||||:...|....|:.|:.:..::.|..|
  Rat   364 RRKACWYPSDFLDALHPQCFSAVLYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGATF 428

  Fly   778 HCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLL 842
            ..::.|||.|:.:|||:|:|:..|..|...:..|:|..|::||:|:....|.:.|.|.|:.||..
  Rat   429 CLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLALVATEASLLVRYF 493

  Fly   843 TRFTQEIFSALITLIYIVETFMKLISIYRE-------NPLLSDYNLPPPTLVAHEHATNESLLNA 900
            ||||:|.|.|||:||:|.:...|::::.|.       :|..|.:...|.|      ..|.|..::
  Rat   494 TRFTEEGFCALISLIFIYDAVGKMLNLIRAYPIQRPGSPAYSCFCQYPGT------GGNASEFDS 552

  Fly   901 TASVTT----NITQMVMNISTTAMPIGPP------------PLPKNQPNTALFCTILTLATFVVA 949
            |....|    |:...::|.|..     ||            |.....|:.|.|..:|...:|:.|
  Rat   553 TMFKDTEDVLNVHPGLVNASFL-----PPSECIRQGGYPRGPSCHTVPDIAFFSLLLFFTSFLCA 612

  Fly   950 YYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI 1014
            ..||..:||.......|:...||...::|.:...:|..: .:.|.||:||....|:.|. |||.:
  Rat   613 IALKHVKNSRLFPSVVRKVFSDFSSVLAILLGCGLDAFL-GLATPKLLVPTEFKPTLPG-RGWLV 675

  Fly  1015 G-FDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGI 1078
            . |..:..|:..|..:||||:.|||||:.||:.:|:::.:..|:||:|.|.|:..:.:|......
  Rat   676 SPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSA 740

  Fly  1079 FGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLI 1143
            .|:||:.:|||.|:.|:.|:...|:...|||.|..:.::||||:|..|.::.|:|:.:||:|:.|
  Rat   741 LGLPWYVSATVISLAHMDSLRRESKACVPGEDPNFLGIREQRLTGLVVFILTGVSIFLAPVLKFI 805

  Fly  1144 PMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLW 1208
            ||.||:|:|||||||::|.:|..:|::|..||.||.|....::.:...::||||.||:.||.|||
  Rat   806 PMPVLYGIFLYMGVAALSSMQFMKRVQLLLMPRKHQPDVLLLRHVPLIRVHLFTAIQLACLGLLW 870

  Fly  1209 SVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALD---GSEMKKNDDDEPD 1259
            .:||:..::.||..|:.:|.:|:.|..::.|:|:..||   ..|.|...::.|:
  Rat   871 VIKSTPAAIVFPLMLLGLVAVRKALEWIFSPQELLWLDELMPEEEKTIPENRPE 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	315/1028 (31%)
		Band_3_cyto	287..618	CDD:284893	87/330 (26%)
		HCO3_cotransp	698..1199	CDD:279322	180/524 (34%)
Slc4a9	NP_690921.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..41
		Band_3_cyto	53..908	CDD:421404	310/1010 (31%)
		Membrane (anion exchange)	385..953		186/553 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	916..938		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650