DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ae2 and Slc4a3

DIOPT Version :9

Sequence 1:NP_648357.1 Gene:Ae2 / 39147 FlyBaseID:FBgn0036043 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_058745.2 Gene:Slc4a3 / 24781 RGDID:3712 Length:1227 Species:Rattus norvegicus


Alignment Length:1225 Identity:508/1225 - (41%)
Similarity:712/1225 - (58%) Gaps:180/1225 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 EEDSEYESQTEPLNNAQNYDDIPEDFPLVSERAGHGDHSDNSVDEKHVQFGGKKKIP-----PSL 143
            ||:.|.||:.||:       :.|...|....:...|...|:|.       |...|.|     ||:
  Rat   141 EEEEEGESEAEPV-------EPPPPGPPQKAKFSIGSDEDDSP-------GLSIKAPCAKALPSV 191

  Fly   144 SYDEQPTDQSHER-------KRRRSRHQYYRQRKFSHQDSVEPKNKL---EENGDAG-ARRISVQ 197
            ..   |:|||.:|       :.|.||....:.|.:|...|.:.:.:|   ...|:.| .:|:   
  Rat   192 GL---PSDQSPQRSGSSPSPRARASRISTEKSRPWSPSASYDLRERLCPGSALGNPGPEQRV--- 250

  Fly   198 PEDTA----LEEADLNELRSHRSDDPRALRRHKIHH-SSIKLRELPQITISPF---TNKKPEVDH 254
            |.|.|    |..|||::::|||.:|...:|||.:.. |.|:........::|.   ..||.::|.
  Rat   251 PTDEAEAQMLGSADLDDMKSHRLEDNPGVRRHLVKKPSRIQGGRGSPSGLAPILRRKKKKKKLDR 315

  Fly   255 SPHEIFVQLDEL-TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETG 318
            .|||:||:|:|| ....::..|:|||||||:||||||.::||||||||||||.|||.|||.:..|
  Rat   316 RPHEVFVELNELMLDRSQEPHWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTIAQG 380

  Fly   319 VVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQ--GVLPFTKRKYNS 381
            ..||||.:..||.:|:.|||.|::.|.|...|:.||:|:|||:|.|.|:.:  |..|   |..:|
  Rat   381 AALLDLEQTTLPGIAHLVVETMIVSDQIRPEDRASVLRTLLLKHSHPNDDKDSGFFP---RNPSS 442

  Fly   382 YTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAI-DHRR 445
            .:....|     ..|.|                    |.|..|..|:..:|......|.: .|  
  Rat   443 SSVNSVL-----GNHHP--------------------TPSHGPDGAVPTMADDLGEPAPLWPH-- 480

  Fly   446 HSTMSYLGNLSGTDDKKIKIMPAAEIGG-SKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIP 509
                          |...|..|....|| ..|...||                      :|::||
  Rat   481 --------------DPDAKEKPLHMPGGDGHRGKSLK----------------------LLEKIP 509

  Fly   510 AGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSI 574
            ..||||.||||:|.|||||..|||||||.||:.::.||||||||:||:|||.:...||||:||||
  Rat   510 EDAEATVVLVGSVPFLEQPAAAFVRLSEAVLLESVLEVPVPVRFLFVMLGPSHTSTDYHELGRSI 574

  Fly   575 STLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIK 639
            :|||:::.||..||:||||:|||.||:||||.|||:||...:..|||              |.:.
  Rat   575 ATLMSDKLFHEAAYQADDRQDLLGAISEFLDGSIVIPPSEVEGRDLL--------------RSVA 625

  Fly   640 ALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGD-----GGGDGDSDDDNGRKKKKPSPLE 699
            |.|    .|:::..::.|:..:|..|.|  |:...|.:     ||.:..|:||         ||:
  Rat   626 AFQ----RELLRKRREREQTKVEMTTRG--GYVAPGKELSLEMGGSEATSEDD---------PLQ 675

  Fly   700 KTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGIS 764
            :||.::|||..|:|||.|.|.||:.|.|:::.:||.:|:|||.||.|||||||:..||...:|:|
  Rat   676 RTGSVFGGLVRDVKRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLGEKTEGLMGVS 740

  Fly   765 ETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALT 829
            |.::|.:::|::|..|..|||:::|.:||||:|:||...||...:.::|:.||:||:||::..|.
  Rat   741 ELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLTGRVWVGLWLVVFVLA 805

  Fly   830 VSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATN 894
            :.|.|||..||.::.||||||:.||:||:|.|||.||..::.|:|||..|   ||     |.|..
  Rat   806 LVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFHKLYKVFTEHPLLPFY---PP-----EEALE 862

  Fly   895 ESL-LNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNS 958
            ..| ||::|                ..|...||.|:|||||||...||.|.||::|::|:.||||
  Rat   863 PGLELNSSA----------------LPPTEGPPGPRNQPNTALLSLILMLGTFLIAFFLRKFRNS 911

  Fly   959 HFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIGFDTSS--- 1020
            .|||..|||.:||||:||||.:.|||||.:...||:||.||.|||.:.|.||.|:|....|:   
  Rat   912 RFLGGKARRVIGDFGIPISILVMVLVDYSITDTYTQKLTVPTGLSVTSPHKRTWFIPPLGSARPF 976

  Fly  1021 -TWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWH 1084
             .|:..|..:|||||.||||||:||:.|||.:..|.|.||||.|.|::|:..|...||:||:||.
  Rat   977 PPWMMVAAAVPALLVLILIFMETQITALIVSQKARRLLKGSGFHLDLLLIGSLGGLCGLFGLPWL 1041

  Fly  1085 CAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLF 1149
            .||||||||||:::|:|....|||:.|:|.:|:|||::|..:..::|||::|..:||.||:||||
  Rat  1042 TAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVTGVLIASLVGLSIVMGAVLRRIPLAVLF 1106

  Fly  1150 GVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQ 1214
            |:||||||.|:||:||.:|:.|.|||.||:|...||.:::.|::||||.||:.|:.|||.|||:.
  Rat  1107 GIFLYMGVTSLSGIQLSQRLLLIFMPAKHHPEQPYVTKVKTWRMHLFTFIQLGCIALLWVVKSTV 1171

  Fly  1215 FSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKN-DDDEPDFYEQTNIP 1267
            .||||||.|::.||:|: .|.:|::..|:||||..:.:.| |:|..|.|.:.::|
  Rat  1172 ASLAFPFLLLLTVPLRRCLLPRLFQDRELQALDSEDAEPNFDEDGQDEYNELHMP 1226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ae2NP_648357.1 ae 260..1267 CDD:273290 452/1023 (44%)
Band_3_cyto 287..618 CDD:284893 140/334 (42%)
HCO3_cotransp 698..1199 CDD:279322 247/505 (49%)
Slc4a3NP_058745.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..255 34/133 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..312 5/25 (20%)
ae 321..1226 CDD:273290 452/1023 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..497 20/112 (18%)
Membrane (anion exchange) 708..1227 263/543 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335804
Domainoid 1 1.000 485 1.000 Domainoid score I379
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 854 1.000 Inparanoid score I410
OMA 1 1.010 - - QHG48894
OrthoDB 1 1.010 - - D173913at33208
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 1 1.000 - - otm45769
orthoMCL 1 0.900 - - OOG6_100185
Panther 1 1.100 - - O PTHR11453
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X102
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1413.810

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