DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ae2 and Slc4a2

DIOPT Version :9

Sequence 1:NP_648357.1 Gene:Ae2 / 39147 FlyBaseID:FBgn0036043 Length:1268 Species:Drosophila melanogaster
Sequence 2:NP_058744.1 Gene:Slc4a2 / 24780 RGDID:3711 Length:1234 Species:Rattus norvegicus


Alignment Length:1289 Identity:498/1289 - (38%)
Similarity:701/1289 - (54%) Gaps:246/1289 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 EEDSEYESQT-----EPLNNAQNYDDIPED-------------------------FPLVSERAGH 118
            |||.||..|:     .||:.     .:|.|                         .|.:.|    
  Rat    68 EEDFEYHRQSSHHIHHPLST-----HLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEE---- 123

  Fly   119 GDHSDNSVDEKHVQFGGKKKIPPSLSYDEQPT--------DQSHERKRRRSRHQYYRQRKFSHQD 175
            |:..::.|.|..    |.:..|...|....|:        |:..:||..|:......|.  .||:
  Rat   124 GEEDEDEVGEAE----GFRAPPQQPSPASSPSAVQFFLQEDEGTDRKAERTSPSPPTQT--PHQE 182

  Fly   176 SVEPKNKLEENG-----------------DAGA--------------------RRI--------- 194
            :....:|..:.|                 |.||                    |||         
  Rat   183 AAPRASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQA 247

  Fly   195 ------SVQPEDTALEEADLNELRSHRSDDPRALRRHKIHH----SSIKLRELPQITISPFTNKK 249
                  :.:.|...|..|||:.::|||.:|...:|||.:..    |:...||..:  ..|....:
  Rat   248 LLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGRE--PGPTPRAR 310

  Fly   250 PEVDHSPHEIFVQLDEL-TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRR 313
            |...|.|||:||:|:|| ....::.:|:|||||||:||||||.::||||||||||||.|||.|||
  Rat   311 PRAPHKPHEVFVELNELQLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRR 375

  Fly   314 CLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRK 378
            .|..|.|||||:::.||.||::|||||||.|.|...|:.:|:|:|||:|.|        |..:::
  Rat   376 TLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSH--------PSDEKE 432

  Fly   379 YNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDH 443
            ::.                        |||:               :|..|........|...:.
  Rat   433 FSF------------------------PRNI---------------SAGSLGSLLGHHHAQGTES 458

  Fly   444 RRHSTMSYLGNLSGTD---DKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTIL 505
            ..|.|...:|.:..|.   |::.::.|.|...|..|             |.|:.:||      :|
  Rat   459 DPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITR-------------SKSKHELK------LL 504

  Fly   506 KRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEV 570
            ::||..||||.||||.||||.:||:|||||.|.|.:..:.||||||||:|:||||.:.::||||:
  Rat   505 EKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEI 569

  Fly   571 GRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLL----PFEELKAKKD 631
            ||||||||:::.||..||.||:|.|||:|||.|||.|:||||......:||    .|:....||.
  Rat   570 GRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKR 634

  Fly   632 WIRTRKI---KALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKK 693
            ..:.|.:   ..|:.|         ..::||||:...:.              |.::||      
  Rat   635 EEQGRLLPPGAGLEPK---------SAQDKALLQMVEVA--------------GAAEDD------ 670

  Fly   694 KPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTN 758
               ||.:|||.:|||..|::||.|.|.||..|.|:.:.|||.||:|||.||.|||||||:..||.
  Rat   671 ---PLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQ 732

  Fly   759 SWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWL 823
            ..||:||.::|.:|.|::|..|..|||::||.:||||:|:||...||..::.::|..||::|.||
  Rat   733 DLIGVSELIMSTALQGVIFCLLGAQPLLVIGFSGPLLVFEEAFFSFCKSNQLEYLVGRVWIGFWL 797

  Fly   824 IIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVA 888
            :::||.:.|.|||..||.::|||||||:.||:||:|.|||.|||.|::|:||             
  Rat   798 VLLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPL------------- 849

  Fly   889 HEHATNESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYYLK 953
              |..:.|..:...|.:.|:|.....::...........|:.||||||...:|...||.:|::|:
  Rat   850 --HGCSVSNDSEADSSSNNMTWAATTLAPDNSSASGQERPRGQPNTALLSLVLMAGTFFIAFFLR 912

  Fly   954 LFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI---G 1015
            .|:||.|.....||.:|||||||:|.|.|||||.:...||:||.||.|.|.:.|.||||.|   |
  Rat   913 KFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLG 977

  Fly  1016 FDTS-STWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIF 1079
            ..|. ..|:..|.::||:||:||||||:||:.||:.|.:|.|:||||.|.|::|:..:...|.:|
  Rat   978 EKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALF 1042

  Fly  1080 GMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIP 1144
            |:||..|||||||||.:::|:||:..|||:.|:|.:|||||::|..|.|::|||:::..|||.||
  Rat  1043 GLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIP 1107

  Fly  1145 MAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWS 1209
            :|||||:||||||.|::|:|.:||:.|..||.||:|..:|||::|..::||||.:|:|||.|||:
  Rat  1108 LAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWA 1172

  Fly  1210 VKSSQFSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKNDDDEPDFYE 1262
            |.|:..||||||.||:.||:|. .||:::...||:.||.:|.      ||.|.|
  Rat  1173 VMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEA------EPVFDE 1220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ae2NP_648357.1 ae 260..1267 CDD:273290 443/1019 (43%)
Band_3_cyto 287..618 CDD:284893 140/333 (42%)
HCO3_cotransp 698..1199 CDD:279322 241/504 (48%)
Slc4a2NP_058744.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..239 33/185 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..315 5/29 (17%)
ae 321..1233 CDD:273290 443/1019 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..467 3/20 (15%)
Membrane (anion exchange) 705..1234 256/537 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166335813
Domainoid 1 1.000 485 1.000 Domainoid score I379
eggNOG 1 0.900 - - E1_KOG1172
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H128699
Inparanoid 1 1.050 854 1.000 Inparanoid score I410
OMA 1 1.010 - - QHG48894
OrthoDB 1 1.010 - - D173913at33208
OrthoFinder 1 1.000 - - FOG0000136
OrthoInspector 1 1.000 - - otm45769
orthoMCL 1 0.900 - - OOG6_100185
Panther 1 1.100 - - O PTHR11453
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X102
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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