Protein Alignment Ae2 and Slc4a1

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_036783.2
• Gene: Slc4a1 / 24779
• RGDID: 3710
• Length: 928
• Species: Rattus norvegicus
• Alignment Length: 1031
• Identity: 387/1031 - (37%)
• Similarity: 560/1031 - (54%)
• Gaps: 188/1031 - (18%)

  Fly   255 SPHEIFVQLDEL--TGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLET 317
            |..:::|:|.||  ....::.:|.|.|.||..||::.| ...||:||::.|:|.|||.|::....
  Rat    67 SSSQVYVELQELMMDQRNQELQWVEAAHWIGLEENLRE-DGVWGRPHLSYLTFWSLLELQKVFSK 130

  Fly   318 GVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRH---VNEHQGVLPFTKRKY 379
            |..||||.|..|..||.::::..:.||.|...|:..::|:|||:..|   :.:.:||.|
  Rat   131 GTFLLDLAETSLAGVANKLLDSFIYEDQIRPQDRDELLRALLLKRSHAEDLKDLEGVKP------ 189

  Fly   380 NSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHR 444
                                                ..:|.|..|:..:|            .|:
  Rat   190 ------------------------------------AVLTRSGAPSEPLL------------PHQ 206

  Fly   445 RHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIP 509
                          ...:.|:..|...|||:..:.                      ..||| ||
  Rat   207 --------------PSLETKLYCAQAEGGSEEPSP----------------------SGILK-IP 234

  Fly   510 AGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSI 574
            ..:|.|.||||...||.:|.:.||||.|.|.:..|. :|.||.|:.|||||....:||.::||:.
  Rat   235 PNSETTLVLVGRASFLVKPVLGFVRLKEAVPLEDLV-LPEPVSFLLVLLGPEAPHIDYTQLGRAA 298

  Fly   575 STLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEE-----LKAKKDWIR 634
            :|||....|...|..|..|.:|||:::.|||.|:||||..      .|.|:     :..:|:.:|
  Rat   299 ATLMTERVFRVTASLAQSRGELLSSLDSFLDCSLVLPPTE------APSEKALLNLVPVQKELLR 357

  Fly   635 TRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLE 699
            .|.:.. ..|.|..:.       :||               .|||.:|..|:|:        ||.
  Rat   358 KRYLPR-PAKPDPNLY-------EAL---------------ADGGKEGPGDEDD--------PLR 391

  Fly   700 KTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGIS 764
            :|||::|||..|::||.|.|.|||.|.|:.:.|||.||:|||.||.|:|||||:..||.:.:|:|
  Rat   392 RTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLGEKTRNLMGVS 456

  Fly   765 ETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALT 829
            |.|||.::.||:|..|..|||:::|.:||||:|:||...||..:..:::..|.::|.|||::.:.
  Rat   457 ELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFYSFCESNNLEYIVGRAWIGFWLILLVVL 521

  Fly   830 VSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATN 894
            |.|||||..|:.::|:||||||.||:||:|.|||.|||.|:::.||...|
  Rat   522 VVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQESY--------------- 571

  Fly   895 ESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQ-PNTALFCTILTLATFVVAYYLKLFRNS 958
                                     .|:...|.|:.. |||||...:|.:.||::|..|:.|:||
  Rat   572 -------------------------APVVMKPKPQGPVPNTALLSLVLMVGTFLLAMMLRKFKNS 611

  Fly   959 HFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG----FDTS 1019
            .:.....||.:|||||||||.|.||||..:...||:||.||:||..|:.|.|||.|.    ::..
  Rat   612 TYFPGKLRRVIGDFGVPISILIMVLVDTFIKNTYTQKLSVPDGLKVSNSSARGWVIHPLGLYNHF 676

  Fly  1020 STWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWH 1084
            ..|:.||.|:|||||:||||:||||:.|||.||:|.:.||||.|.|::|:..:.....:|||||.
  Rat   677 PKWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWL 741

  Fly  1085 CAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLF 1149
            .|.|||||||.:::|:|.:...||.:.:|.:|||||:||..|.:::|||:||.|:|..||:||||
  Rat   742 SATTVRSVTHANALTVMGKASGPGAAAQIQEVKEQRISGLLVSVLVGLSILMEPILSRIPLAVLF 806

  Fly  1150 GVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQ 1214
            |:|||||:.|:||:|||:||.|.|.|.|::|...:|||::.|::||||.||::||.:||.|||:.
  Rat   807 GIFLYMGITSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTP 871

  Fly  1215 FSLAFPFFLIMMVPIRQNLTKL-YKPEEMQALDGSEMKKNDDDEP--DFYEQTNIP 1267
            .|||.||.||:.||:|:.|..| ::..|:|.|||.:.|...|:..  |.|::..:|
  Rat   872 ASLALPFVLILTVPLRRLLLPLIFRELELQCLDGDDAKVTFDEAEGLDEYDEVPMP 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	385/1024 (38%)
Slc4a1	NP_036783.2	Globular. /evidence=ECO:0000250	69..303		89/326 (27%)
		ae	72..927	CDD:273290	385/1024 (38%)
		Interaction with ANK1. /evidence=ECO:0000250	190..199		2/8 (25%)
		Dimerization arm. /evidence=ECO:0000250	317..370		19/59 (32%)