Protein Alignment Ae2 and Slc4a9

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_006525969.1
• Gene: Slc4a9 / 240215
• MGIID: 2443384
• Length: 953
• Species: Mus musculus
• Alignment Length: 1028
• Identity: 316/1028 - (30%)
• Similarity: 502/1028 - (48%)
• Gaps: 180/1028 - (17%)

  Fly   259 IFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLD 323
            :|:||:||.|..:..||:||.||:.:||.::.|:.||..|||.:|...||..||..|..|:||||
Mouse    52 LFIQLNELLGWPQALEWRETGRWLLFEEKLDMGAGRWSAPHVPTLELPSLQKLRSLLAEGIVLLD 116

  Fly   324 LNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFL 388
            ...:.|    ..:|||:|..:.:....:..:...||.|.:|..:..|:.|.  |:.|::
Mouse   117 CQAQSL----LELVEQVVSGESLSPELRGQLQALLLQRPQHHIQTMGIRPC--RESNAF------ 169

  Fly   389 WMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLG 453
                                 .||.|.    ..||
Mouse   170 ---------------------RKASRD----EDAP------------------------------ 179

  Fly   454 NLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVL 518
                                .|..|.|:                        :::||||||..||
Mouse   180 --------------------LKHQNPLR------------------------QKLPAGAEAAAVL 200

  Fly   519 VGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHF 583
            .|.:.|||||..|||||...:::..|||:.:|.||..:||||......|||:||:.:.|:::..|
Mouse   201 AGELGFLEQPLGAFVRLRNPIVLEPLTEMILPSRFFCLLLGPPTLGRSYHEMGRAAAVLLSDPQF 265

  Fly   584 HSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSE 648
            .....:|....|||:|::.||.:...||||.|||...:|            ..|....|.||..
Mouse   266 QWSVRRASHLPDLLAALDAFLQEVTALPPGRWDRTARIP------------PPKYLPSQHKRFP- 317

  Fly   649 MIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSP-LEKTGRLWGGLRNDL 712
                .|.:|...|.:|:...               ::|.:......|.| |::||||:|||..|:
Mouse   318 ----SKLQEVTSLSRQSAAL---------------AEDKHHHGPHTPIPELQRTGRLFGGLIQDV 363

  Fly   713 KRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVF 777
            :|:...|.||.||.|:.:..:|..::|.|.::.|||||||:...|....|:.|:.:..::.|..|
Mouse   364 RRKACWYTSDFLDALHPQCFSAVFYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGAAF 428

  Fly   778 HCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLL 842
            ..::.|||.|:.:|||:|:|:..|..|...:..|:|..|::||:|:....|.:.|.|.|:.||..
Mouse   429 CLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVTAFCLALVATEASLLVRYF 493

  Fly   843 TRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAH----EHATNESLLNATAS 903
            ||||:|.|.|||:||:|.:...|::::.|.      |.:..|...|:    ::.......:...|
Mouse   494 TRFTEEGFCALISLIFIYDAMGKMLNLIRA------YPIQRPGSSAYGCFCQYPGTGGNTSEWTS 552

  Fly   904 VTTNITQMVMNIS---TTAMPIGPP-----------PLPKNQPNTALFCTILTLATFVVAYYLKL 954
            .....|:.::::.   ..|..:.||           |.....|:.|.|..:|...:|:.|..||.
Mouse   553 AKLKDTEDILSVQPGLVNASFLPPPECIRQGGHPLGPSCHTVPDIAFFSLLLFFTSFLCAIALKH 617

  Fly   955 FRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDT 1018
            .:||.|.....|:.||||...::|.:...:|..: .:.|.||:||....|: .|.|||.:. |..
Mouse   618 IKNSRFFPSVVRKVLGDFSSVLAILLGCGLDTFL-GLATPKLLVPTEFKPT-LSGRGWLVSPFGA 680

  Fly  1019 SSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPW 1083
            :..|:..|..:||||:.|||||:.||:.:|:::.:..|:||:|.|.|:..:.:|.......|:||
Mouse   681 NPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPW 745

  Fly  1084 HCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVL 1148
            :.:|||.|:.|:.|:...|:...|||:|..:.::||||:|..|.::.|:|:.:||:|:.|||.||
Mouse   746 YVSATVISLAHIDSLRRESKACIPGEAPNFLGIREQRLTGLVVFVLTGVSIFLAPVLKFIPMPVL 810

  Fly  1149 FGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSS 1213
            :|:|||||||::|.:|..:|::|..||.||.|....::.:...::||||.||:.||.|||.|||:
Mouse   811 YGIFLYMGVAALSSIQFVKRVQLLLMPRKHQPDMLLLRHVPLSRVHLFTAIQLACLGLLWVVKST 875

  Fly  1214 QFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDGSEMKKNDDD-------EPD 1259
            ..::.||..|:.:|.||:.|..::.|:|:..||  |:...:::       ||:
Mouse   876 PAAIVFPLMLLGLVAIRKALEWVFSPQELLWLD--ELMPEEEETIPENRSEPE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	316/1027 (31%)
		Band_3_cyto	287..618	CDD:284893	87/330 (26%)
		HCO3_cotransp	698..1199	CDD:279322	178/519 (34%)
Slc4a9	XP_006525969.1	Band_3_cyto	53..908	CDD:391624	311/1005 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750