DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and Slc4a5

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_006506026.1	Gene:	Slc4a5 / 232156	MGIID:	2443220	Length:	1272	Species:	Mus musculus

Alignment Length:	1334	Identity:	386/1334 - (28%)
Similarity:	615/1334 - (46%)	Gaps:	351/1334 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 VDEKHVQFGGKKKIPPSLSYDEQPTDQSHERKRRRSRHQY-----------YRQRKFSH------ 173
            |||:.   .|.||:.|: ||           |||:....:           |.|||...
Mouse     3 VDEEK---AGVKKLDPT-SY-----------KRRQPEQDFPSIHIGFPVPSYSQRKSDSKGHLSG 52

  Fly   174 ----QDSVEPKNKLEENGDAGARRISVQPEDTALEEADLNELRSHRSDDPRALRRHKIHHSSIKL 234
                |.|::|....:|....|.|..|   :..|::       .:.|:..|.|
Mouse    53 LQKVQWSLKPGKPQQELAGPGIRASS---QGGAVD-------FTKRTRSPAA------------- 94

  Fly   235 RELPQITISPFTNKKPEVDHSPH-EIFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKP 298
            .:|..|.        .|.|.:|: .:|.::|.|...|:..||||:|||||:||.||||.:||.||
Mouse    95 EQLQDIL--------GEEDEAPNPTLFTEMDTLQHDGDQMEWKESARWIKFEEKVEEGGERWSKP 151

  Fly   299 HVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHR 363
            ||::||.|||..||.||:||.|||||:...||.:...|:|:.:.:.|:....:..|...||.:||
Mouse   152 HVSTLSLHSLFELRTCLQTGTVLLDLDSCSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRKHR 216

  Fly   364 HVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVT-------SS 421
            |                                   |..:|..|:||...:|:..|       ||
Mouse   217 H-----------------------------------QTKKPIHRSLADIGKSVSTTNRSSARSSS 246

  Fly   422 APPT----AAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKI 482
            |.||    ...|.:..:| :...:.|.:..:|:.:.:...||.:|.|.|
Mouse   247 AGPTLHRSTEDLRIRQST-SYGHLCHAQSRSMNDISHTPNTDQRKNKFM---------------- 294

  Fly   483 DMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEV 547
                                   |:||..:||:.||||.|:||:||.||||||.:..::..:|||
Mouse   295 -----------------------KKIPKDSEASNVLVGEVDFLDQPFIAFVRLVQSAMLGGVTEV 336

  Fly   548 PVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPP 612
            |||.||:|:||||......|:|:||:|:|||.::.|..:||||.:|:||::.|:||||:.|||||
Mouse   337 PVPTRFLFILLGPSGRAKSYNEIGRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPP 401

  Fly   613 GNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTI---- 673
            |.||.:              ||....|.:.          ..|:.|::......|.:..::
Mouse   402 GEWDPN--------------IRIEPPKKVP----------SADKRKSVFSLAEPGQMNGSVGGGG 442

  Fly   674 ----GGGDGGGDGDS-------------------------------------------------- 684
                |||.|||.|.|
Mouse   443 ASAGGGGSGGGAGGSGAGGVGSGDEAEMPAMHEIGEELIWTGRCPLHTWQRACCPEPFLLPVLLA 507

  Fly   685 -----------DDDN-------------------GRKKKKPSPLEK------------------- 700
                       |.|.                   |...::..|:.|
Mouse   508 ILSLLCAAPLRDGDLTTAVVPHSSESCGSDRIVWGEMNRRIPPVRKEPKHFSRHSLVIVSYSGRN 572

  Fly   701 ---TGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIG 762
               ..|.:|||..|:||::|.:.||..||.:.::::|.:|:|..|::.|||||||:...|:::.|
Mouse   573 NVSQARFFGGLCLDVKRKLPWFPSDFYDGFHLQSISAVLFIYLGCITNAITFGGLLGDATDNYQG 637

  Fly   763 ISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIA 827
            :.|:.:..::.|.:|...|.|||:|:.:|||:|:|::.|..|...:..|::..|:::|:...|..
Mouse   638 VMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKANGLDYMEFRLWIGLHSAIQC 702

  Fly   828 LTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYN-----------L 881
            |.:.|.:.|..::.:||||:|.||.||:.|:|.:...|:|..::..|:.:|:.           :
Mouse   703 LILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAFKYYPINTDFKPDFITTYKCECV 767

  Fly   882 PPPT----------------------------LVAHEHATNESLLNATASVTTNI-TQMVMNIST 917
            .|.|                            .::.|...|.:.:||:|.:..|. |.:...::.
Mouse   768 APDTDGGGRREGFIDENWTSSLSAAWAGIMAPSISSETLVNTTTVNASAPLAPNTNTSLYTPLNL 832

  Fly   918 TAMPIGPPPLPKNQ----------------PNTALFCTILTLATFVVAYYLKLFRNSHFLGRNAR 966
            ||:...  .|.|.:                |:.||...||...|:.:...||.|:.|.:.....|
Mouse   833 TALDWS--LLSKKECLSYGGRLLGSSCQFVPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVR 895

  Fly   967 RALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFACVIP 1030
            ..:.||.:..||.:|..:|... .:.|.||.||..:.|:.|. |||::. |..:..|:..|.::|
Mouse   896 TLVADFSIVFSILLFCGIDACF-GLQTPKLHVPSVIKPTRPD-RGWFVAPFGKNPWWVYPASILP 958

  Fly  1031 ALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHV 1095
            ||||.|||||:.||:.:||::.:..|:|.:|.|.|:..:.:|...|...|:||:.||||.|:.|:
Mouse   959 ALLVTILIFMDQQITAVIVNRKENKLRKAAGYHLDLFWVGILMALCSFTGLPWYVAATVISIAHI 1023

  Fly  1096 SSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASM 1160
            .|:.:.:.|.||||.|:.:.|:|||::|..|.::.|:||.:||:|:.|||.||:||||||||||:
Mouse  1024 DSLKMETETSAPGEQPQFLGVREQRVTGVMVFILTGISVFLAPILKYIPMPVLYGVFLYMGVASL 1088

  Fly  1161 SGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIM 1225
            :|:|.:||.:|:.||.||.|..::::.:...::||||.:|:|||.|||.:||:..::.||..::.
Mouse  1089 NGIQFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLALLWILKSTMAAIIFPVMILG 1153

  Fly  1226 MVPIRQNLTKLYKPEEMQALDG--SEMKKNDDDE 1257
            ::.:|:.|..::...::..:|.  .|..|.:.|:
Mouse  1154 LIIVRRLLDLIFSQHDLAWIDNILPEKDKKETDK 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	354/1178 (30%)
		Band_3_cyto	287..618	CDD:284893	120/341 (35%)
		HCO3_cotransp	698..1199	CDD:279322	184/579 (32%)
Slc4a5	XP_006506026.1	Band_3_cyto	113..1174	CDD:391624	350/1163 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650