Protein Alignment Ae2 and Slc4a7

DIOPT Version :9

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_006518061.1
• Gene: Slc4a7 / 218756
• MGIID: 2443878
• Length: 1274
• Species: Mus musculus
• Alignment Length: 1185
• Identity: 412/1185 - (34%)
• Similarity: 607/1185 - (51%)
• Gaps: 192/1185 - (16%)

  Fly   210 ELRSHR----------SDDPRAL---RRHKIHHSSIK--------LRELPQITISP-------FT 246
            ||.|||          |.:.|..   |.||.||...|        .||.|... :|       ..
Mouse    41 ELESHRAVYVGVHVPFSKESRRRHKHRGHKHHHRRRKDKDSDKEDGRESPSYD-TPSQRVQFILG 104

  Fly   247 NKKPEVDHSPHEIFVQLDELT-GVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLN 310
            .:..:.:|.||::|.::|||. ..||:.||||||||:|:|||||:|.|||.||:||:||.|||..
Mouse   105 TEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFE 169

  Fly   311 LRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFT 375
            ||.|:..|.|:||:....|..:|..|::.|:....:|.:.:.:|..:||.||.|.||.:    ||
Mouse   170 LRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDDSIRENVREALLKRHHHQNEKR----FT 230

  Fly   376 KR------------KYNS-----------YTSLQFLWMGADSAHQPYQQAQP---------PPRN 408
            .|            |::.           ..|...|..|..:::...:...|         |...
Mouse   231 SRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLSHLLPSSR 295

  Fly   409 LAKARRSICVT-----SSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPA 468
            ......|.|.|     .|:||::..|    :..|:.:....:......|.:....|..::.|.|.
Mouse   296 AGTPAGSRCTTPVPTPQSSPPSSPDL----SRLASRSFQQTQPQAPEVLVSPDRDDIPRVVIHPP 356

  Fly   469 AE----IGGSKRSNELKI-----------------------DMKDDMYSSSQED----------- 495
            .|    :.|.::.||...                       :||.:....|:|:
Mouse   357 EEDIEALKGQEQKNEENTAFTPGILASPQSAPGNLDNSKSGEMKGNGSGGSRENSTVDFSKESAS 421

  Fly   496 -----------LKKLQND-TILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVP 548
                       |||...| ..:::||.||||:.||||.|:|||:|.||||||:..||:..|||||
Mouse   422 WHCSCGTLGVGLKKPAVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLSGLTEVP 486

  Fly   549 VPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPG 613
            ||.||:|:||||......|||:||||:|||.:|.||.:||||.||.||||.|:||||...|||||
Mouse   487 VPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPG 551

  Fly   614 NWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDG 678
            .||..              ||....|::            ..:||..:.....|:...::
Mouse   552 EWDPS--------------IRIEPPKSV------------PSQEKRKIPVFPNGSAAMSV----- 585

  Fly   679 GGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACL 743
              |...:||:....:    |::||||:|||..|:||:.|.:.||..|.|:.:.||:.:|:|.||:
Mouse   586 --DPPKEDDHHAGPE----LQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACM 644

  Fly   744 STAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQH 808
            |..||||||:...|...|...|:|...||.||.:...:.|||.|:|:|||:|:|::.|..||..:
Mouse   645 SPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCRDY 709

  Fly   809 EFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLI---SIY 870
            ...:||||..:|:|...:.:.:.|.:.|..|..:||||:|.|:|||.:|:|.|...||.   .||
Mouse   710 HLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFHLGEIY 774

  Fly   871 RENPLLSDYNLPPPTLVAHE--HATNESL-----LNATA--------SVTTNITQMVMNISTTAM 920
            ..|...:...|...|.|..|  :.:||:|     .|.||        :|:...|...|.:.:...
Mouse   775 AFNMHNNLDELTSYTCVCAEPSNPSNETLELWKRKNITAYSVSWGNLTVSECKTFHGMFVGSACG 839

  Fly   921 PIGPPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVD 985
            |.||     ..|:...:|.:|...||.::.:||.|:...:.....|..:.||.|.::|.|.|.:|
Mouse   840 PHGP-----YVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVAID 899

  Fly   986 YLVPAVYTEKLVVPEGLSPSDPSKRGWYIG-FDTSSTWIPFACVIPALLVYILIFMESQISELIV 1049
            ||| .:.:.||.|||...|:||| |||.|. ...:..|......:||||..|||||:.||:.:|:
Mouse   900 YLV-GIPSPKLHVPEKFEPTDPS-RGWIISPLGDNPWWTLLIAAVPALLCTILIFMDQQITAVII 962

  Fly  1050 DKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIV 1114
            ::.:..||||:|.|.|::::.::...|.|.|:||..||||.|::||:|:.:.|...||||.|:.:
Mouse   963 NRKEHKLKKGAGYHLDLLMVGVMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFL 1027

  Fly  1115 DVKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHY 1179
            .::|||::|..:.:::||||.|..:|:.|||.||:||||||||:|:.|:|.|:||:|:.||.||.
Mouse  1028 GIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMPAKHQ 1092

  Fly  1180 PPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQA 1244
            |...|::.:..||:|:||.:|:.||||||.:|:|..::.||..::.:|.:|:.:...:...|:..
Mouse  1093 PDLIYLRYVPLWKVHVFTVVQLTCLVLLWVIKASAAAVVFPMMVLALVFVRKLMDLCFTKRELSW 1157

  Fly  1245 LDG----SEMKKNDD 1255
            ||.    |:.||.||
Mouse  1158 LDDLMPESKKKKEDD 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	392/1107 (35%)
		Band_3_cyto	287..618	CDD:284893	141/417 (34%)
		HCO3_cotransp	698..1199	CDD:279322	204/519 (39%)
Slc4a7	XP_006518061.1	Band_3_cyto	118..1159	CDD:391624	385/1092 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1172
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265068at2759
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100185
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1874
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.680