Protein Alignment Ae2 and Slc4a2

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_033233.2
• Gene: Slc4a2 / 20535
• MGIID: 109351
• Length: 1237
• Species: Mus musculus
• Alignment Length: 1291
• Identity: 504/1291 - (39%)
• Similarity: 707/1291 - (54%)
• Gaps: 246/1291 - (19%)

  Fly    84 EEDSEYESQT-----EPLNNAQNYDDIPEDFPLVSERAGHGDH----------------SDNSVD 127
            |||.||..|:     .||:.     .:|.|........|.|..                .:...|
Mouse    67 EEDFEYHRQSSHHIHHPLST-----HLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEED 126

  Fly   128 EKHVQFGGKKKIPPSLSYDEQPT--------------DQSHERKRRRSRHQYYRQRKFSHQDSVE 178
            |:........:.||     :||:              |:..|||..|:......|.  .||::..
Mouse   127 EEEASEAEGFRAPP-----QQPSPATTPSAVQFFLQEDEGAERKPERTSPSPPTQT--PHQEAAP 184

  Fly   179 PKNKLEENG-----------------DAGA--------------------RRI------------ 194
            ..:|..:.|                 |.||                    |||
Mouse   185 RASKGAQTGTLVEEMVAVASGTAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLP 249

  Fly   195 ---SVQPEDTALEEADLNELRSHRSDDPRALRRHKIHH----SSIKLRELPQITISPFTNKKPEV 252
               :.:.|...|..|||:.::|||.:|...:|||.:..    |:...||..:  ..|....:|..
Mouse   250 RVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGRE--PGPTPRARPRA 312

  Fly   253 DHSPHEIFVQLDE-LTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLE 316
            .|.|||:||:|:| |....::.:|:|||||||:||||||.::||||||||||||.|||.|||.|.
Mouse   313 PHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLA 377

  Fly   317 TGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNS 381
            .|.|||||:::.||.||::|||||||.|.|...|:.:|:|:|||:|.|        |..:::::.
Mouse   378 HGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSH--------PSDEKEFSF 434

  Fly   382 YTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRH 446
                                    |||:               :|..|........|...:...|
Mouse   435 ------------------------PRNI---------------SAGSLGSLLGHHHAQGTESDPH 460

  Fly   447 STMSYLGNLSGTD---DKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRI 508
            .|...:|.:..|.   |::.::.|.|...|..|             |.|:.:||      :|::|
Mouse   461 VTEPLIGGVPETRLEVDRERELPPPAPPAGITR-------------SKSKHELK------LLEKI 506

  Fly   509 PAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRS 573
            |..||||.||||.||||.:||:|||||.|.|.:..:.||||||||:|:||||.:.::||||:|||
Mouse   507 PENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRS 571

  Fly   574 ISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLL----PFEELKAKKDWIR 634
            |||||:::.||..||.||:|.|||:|||.|||.|:||||......:||    .|:....||...:
Mouse   572 ISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQ 636

  Fly   635 TRKI---KALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPS 696
            .|.:   ..|:.|         ..::||||:...:.              |.::||
Mouse   637 GRLLPPGAGLEPK---------SAQDKALLQMVEVA--------------GAAEDD--------- 669

  Fly   697 PLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWI 761
            ||.:|||.:|||..|::||.|.|.||..|.|:.:.|||.||:|||.||.|||||||:..||...|
Mouse   670 PLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTKDLI 734

  Fly   762 GISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIII 826
            |:||.::|.:|.|:||..|..|||::||.:||||:|:||...||:.:|.::|..||::|.||:.:
Mouse   735 GVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNELEYLVGRVWIGFWLVFL 799

  Fly   827 ALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEH 891
            ||.:.|.|||..||.::|||||||:.||:||:|.|||.|||.|::|:||               |
Mouse   800 ALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPL---------------H 849

  Fly   892 ---ATNESLLNATAS--VTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTILTLATFVVAYY 951
               .:|:|...:::|  :|...|.:|.:.|:.:...|... |:.||||||...:|...||.:|::
Mouse   850 GCSGSNDSEAGSSSSSNMTWATTILVPDNSSASGQSGQEK-PRGQPNTALLSLVLMAGTFFIAFF 913

  Fly   952 LKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYI-- 1014
            |:.|:||.|.....||.:|||||||:|.|.|||||.:...||:||.||.|.|.:.|.||||.|
Mouse   914 LRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINP 978

  Fly  1015 -GFDTS-STWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACG 1077
             |..|. ..|:..|.::||:||:||||||:||:.||:.|.:|.|:||||.|.|::|:..:...|.
Mouse   979 LGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICA 1043

  Fly  1078 IFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLLRL 1142
            :||:||..|||||||||.:::|:||:..|||:.|:|.:|||||::|..|.|::|||:::..|||.
Mouse  1044 LFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQ 1108

  Fly  1143 IPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLL 1207
            ||:|||||:||||||.|::|:|.:||:.|..||.||:|..:|||::|..::||||.:|:|||.||
Mouse  1109 IPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALL 1173

  Fly  1208 WSVKSSQFSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKNDDDEPDFYE 1262
            |:|.|:..||||||.||:.||:|. .||:::...||:.||.:|.      ||.|.|
Mouse  1174 WAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEA------EPVFDE 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	449/1024 (44%)
Slc4a2	NP_033233.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..238		33/182 (18%)
		PTZ00449	<3..321	CDD:185628	55/267 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..316		6/32 (19%)
		ae	320..1236	CDD:273290	449/1024 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..466		3/20 (15%)
		Membrane (anion exchange)	704..1237		262/542 (48%)