Protein Alignment Ae2 and abts-4

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001024826.2
• Gene: abts-4 / 180943
• WormBaseID: WBGene00019844
• Length: 956
• Species: Caenorhabditis elegans
• Alignment Length: 1071
• Identity: 278/1071 - (25%)
• Similarity: 478/1071 - (44%)
• Gaps: 226/1071 - (21%)

  Fly   249 KPEVDHSP---HEIFVQLDELTGVGEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLN 310
            :|.::.||   |:..:.:|..|...:|..||:.:|:.:||||.|...:..|:|||.
 Worm    59 RPRLEDSPVAEHDHHIVVDVFTVNNDDGTWKQASRFARYEEDCEGFDNHLGRPHVP--------- 114

  Fly   311 LRRCLETGV--VLLDLNEKDL--PAVAYRVVEQMV--IEDLIDINDKPSVMRSL--LLRHRHVNE 367
               |:..|.  .|..:..|.:  |.|.|..:::.|  :|..|...|.|.:...:  |:..| :.|
 Worm   115 ---CIPMGTYDALKMVTAKSILFPKVQYESLDEFVNFLETKIVDPDVPKLGEKIAKLINDR-IAE 175

  Fly   368 HQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVA 432
            .:.:.|..:|..:|..||.                                 :|.|.|.:.:.:.
 Worm   176 IEKMRPLHQRNSSSTQSLD---------------------------------ASNPQTISTVGIF 207

  Fly   433 TATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIG---GSKRSNELKIDMKDDMYSSSQE 494
            .            .|.:|...||.......::.:|.:..|   ||.             :...|.
 Worm   208 P------------RSLLSAPNNLGSLAHHPMRRLPTSHSGLRFGSS-------------FLPQQP 247

  Fly   495 DLKKLQ-----NDTILKRIPAGAEATTVLVG---AVEFLEQPTIAFVRLSEGVLMPTLTEVPVPV 551
            .:.:|:     .|..:..:.|| |...|.|.   |:.|:|  |.|..:     :.|.:|.    |
 Worm   248 VVSQLEPVIWDEDNEISMLVAG-EIPHVNVCRFIAIRFVE--TTAMEK-----IFPNMTN----V 300

  Fly   552 RFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWD 616
            |.:|.|:||...::.|.::||:::::::|....:...:......:..||..||..::|:.||..|
 Worm   301 RHLFFLIGPALENVTYLDLGRALASVVSNPPATTTFDQLKSPDSITKAIERFLAGTVVIAPGRID 365

  Fly   617 RHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGD 681
            ..:|:       :.|.|  ||:..:|.:         |.|.|.:..|
 Worm   366 NKNLV-------RSDLI--RKLVNMQGE---------KTETKIVHPK------------------ 394

  Fly   682 GDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLSTA 746
             |.|.:....||.....:|..||:.|:.:||:.|...|.||..||.|........:|:...:...
 Worm   395 -DVDVERNATKKAEEAEDKPFRLFSGVTSDLRNRAKHYFSDYRDGFNISIFTVVFYMFCVTVVPT 458

  Fly   747 ITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFD 811
            :|||.::.|.|:..:.:.|.|:|.:|.|:::..||||||:::..|||.|:|::||..|..|::.|
 Worm   459 LTFGAIMGAGTSGLLAVKECLVSQALSGLIWSVLSCQPLLVMSPTGPFLVFEKALFKFTDQNDMD 523

  Fly   812 FLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVET--FMKLISIYRENP 874
            ||.:|.|.|::|..|::..:|...:..:..:|.:|::||.|||:||:..|.  |:.|
 Worm   524 FLEVRFYTGIFLFFISIVGAATNCAHLIHYVTIYTEDIFCALISLIFFSEVVEFIHL-------- 580

  Fly   875 LLSDYNLPPPTLVAHEHATNESLL----NATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTA 935
                         ..||.:.|:|.    ||.....|.:....:                ::|||.
 Worm   581 -------------QEEHNSIENLKYYIENAANCTVTEVKDCAL----------------SRPNTF 616

  Fly   936 LFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFG-----VPISIAIFVLVDYLVPAVYTEK 995
            |...|:.:.:..:.:||:....|.|.||..|....:||     :.:|||..:|...:..||
 Worm   617 LLQLIMVVVSIAIFHYLRQVSRSTFFGRTFRNLCKNFGGIFAVIAVSIAYRILFQNVGVAV---- 677

  Fly   996 LVVPEGLSPSDPSKRGWYIGFD----------TSSTWIPFACVIPALLVYILIFMESQISELIVD 1050
            :.:|..:..|.|        ||          |:||..  ..:|.::|:::|||:|::|.|.:..
 Worm   678 VDIPVAVGQSRP--------FDGIFVIPSAPPTASTLT--IALISSILLFVLIFVETEIPEQMAL 732

  Fly  1051 KPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVD 1115
            :..|.||||.|||||::::........:.|:||.|.|.|:|:.|::|:|...:: |||...||..
 Worm   733 REGRKLKKGGGLHWDLIVVGFCTLVSSVLGLPWMCPAAVQSLAHITSLTEYKKS-APGVPSRISH 796

  Fly  1116 VKEQRLSGFFVCLMIGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYP 1180
            |.|||:||....|::|...::...| .||.|.:||||.|:||.::.|.::..|::|.|:|.|:..
 Worm   797 VIEQRVSGMVTYLLLGTFAILGHFL-AIPAATIFGVFFYLGVRNLEGSKMILRLKLCFLPSKYRG 860

  Fly  1181 PTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQF-SLAFPFFLIM-MVPIRQNLTKLYKPEEMQ 1243
            ...:::....:.:.::|.||.|....:::.|||:. .|.||.|::. .:.::..|:.::..|.::
 Worm   861 SHKFLEIAPFYTIQIYTVIQYLIAGAMFAAKSSKIGGLLFPLFIVSNAIFVKHGLSVIFDKELLE 925

  Fly  1244 ALDGSEMKKNDD------DEP-DFYEQTNIP 1267
            ||| ||...|||      :.| |||:.|.||
 Worm   926 ALD-SEDHDNDDADRDNEENPEDFYQNTRIP 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	272/1055 (26%)
abts-4	NP_001024826.2	HCO3_cotransp	415..879	CDD:480978	153/516 (30%)