Protein Alignment Ae2 and abts-3

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_001355414.1
• Gene: abts-3 / 174024
• WormBaseID: WBGene00019018
• Length: 1043
• Species: Caenorhabditis elegans
• Alignment Length: 1269
• Identity: 274/1269 - (21%)
• Similarity: 480/1269 - (37%)
• Gaps: 344/1269 - (27%)

  Fly    82 NIEEDSEYESQTEPLNNAQNYDDIPEDFPL-------------------------VSERAGH--- 118
            ::.:.|:.:|...||:.|.....|.|::||                         ::.|..|
 Worm    14 SVRKGSDVDSYRTPLDFASCSSGISEEYPLLLKNGDDGISQGGIYIKKPDPRQRVMARRTSHTLL 78

  Fly   119 --------GDHSDNSV---DEKHVQFGGKK--KIPPSLSYDEQPTDQSHERKRRRSRHQY--YRQ 168
                    .:.|.|||   ....||..|::  |:||:.|:....:.....||..::....  :|.
 Worm    79 YVPEQRRISNVSGNSVASCPPGTVQTSGEEDDKVPPAPSFSLHLSPVGTRRKSVQTGAPAIGFRP 143

  Fly   169 RKFSHQDSVEPKNKLE-----------ENGDAG----------ARRISVQPEDTAL--EEADLNE 210
            .|...:.:.:|..:.|           ..|.||          :..||:.|:...:  :......
 Worm   144 LKTFERRASQPTLQFEAKKATMNSGTSSGGTAGGTVNLINTAQSTTISLPPDKAKMLTKRVSWLS 208

  Fly   211 LRSHRSDDPRALRRHKI--HHSSIKLRELPQITISPFTNKKPEVD-HSPHEIFVQLDELTGVGED 272
            ::|.:.:||:..|....  .......|.|.|....||..:..:.| .:|     .||.|:.....
 Worm   209 MKSLQQEDPKTRRSSACGSPRGGSPSRTLSQYGSQPFLAEDRDFDSDTP-----PLDTLSWSNAG 268

  Fly   273 REWKE-TARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRV 336
            .|:.. |..:.|:|:...:.   :|....|::....|||      ..|:||||.|..|..:..::
 Worm   269 NEYDNVTLMYAKHEKIPMKD---FGSEIRATMDIDHLLN------KAVLLLDLQETSLEEIFAKI 324

  Fly   337 VEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQ 401
            :.:|.|::....:::   :||:|              ||:...|.:
 Worm   325 IHEMDIQEPEFTSEQ---VRSVL--------------FTQDAGNQF------------------- 353

  Fly   402 AQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIM 466
                 ..|::..:|||.|.|
 Worm   354 -----HILSRTVQSICTTGS--------------------------------------------- 368

  Fly   467 PAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIA 531
                :|||...::..|                               ....::..|:...   :|
 Worm   369 ----VGGSFDYDQTWI-------------------------------CALCMLNTVQHRH---VA 395

  Fly   532 FVRLSEGVLMPT-LTEVPVPVRFMFVLLGPRNF--DLDYHEVGRSISTLMANEHFHSIAYKADD- 592
            ..|||.    || |......:||:.:::.|...  .....|..|:.:||.|:.........|..
 Worm   396 IARLSH----PTNLGRTMQDLRFIIIVIAPSRAKGTKTALETTRTFATLFADMEIRQRLVMAQSV 456

  Fly   593 ---RKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDSEMIKIGK 654
               |..||||..|...|                      :..| |.|| .::.:....|.| .|.
 Worm   457 EQFRSTLLSAAKELAMD----------------------QNQW-RERK-SSIHLSHAKEQI-FGP 496

  Fly   655 DEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLW---GGLRNDLKRRM 716
            :                                                .|   .||..:.|||:
 Worm   497 E------------------------------------------------AWYPFRGLVEEFKRRL 513

  Fly   717 PMYKSDILDGLN-----TETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIV 776
            .:|.||.|||:.     .:..:..:|:|||||..||.||.|....|...|.:.:.:|:.::.||.
 Worm   514 AIYPSDYLDGIRGHKTVQKLFSTVVFLYFACLLPAIAFGVLNDDNTKGAINVRKVIIAQAIGGIF 578

  Fly   777 FHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRL 841
            |.....||::|:.||.||.::.:.:.....:..:|||::...||::..:..:..||.|....::.
 Worm   579 FSLFGGQPMIILLTTVPLAIYIKVIFKISQELGYDFLAMYACVGLFCQMFLILYSATELCSLMKF 643

  Fly   842 LTRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNATASVTT 906
            .||..:|:||..|.:.:.||:...:.:.:::|     ||....:.::.:.|  .:.|||..: .:
 Worm   644 ATRSAEEMFSLFIAIAFTVESIRAIHNSFKKN-----YNDCDTSAISMKAA--RTALNAFKN-GS 700

  Fly   907 NITQMVMNISTTAMPIGPP-PLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALG 970
            |...:|.|| |::|.||.. .|.:.  :|::...:|...|..:..:|..||.:.:|.|:.|..|.
 Worm   701 NADSIVGNI-TSSMSIGDTGSLCRR--DTSILYMLLMFGTLWLGLFLYNFRKTPYLTRSRREWLA 762

  Fly   971 DFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSKRGWYIGFD------TSSTWIP----F 1025
            |:.:|.|:.|.....               ..:.||..|..:.:.|:      ...|.:|    |
 Worm   763 DYALPASVLIMSFTG---------------SYAFSDIEKDRFNLRFEFPLIQMADVTSLPPSGYF 812

  Fly  1026 ACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVR 1090
            .|::....:..|.|::..|:..||:.....||||:..:.|:.::.|||....:||:||...|...
 Worm   813 VCLLLGFSLSFLFFIDQNITSAIVNNNQNKLKKGTSHNLDLFVVALLNMFLSVFGLPWMHGALPH 877

  Fly  1091 SVTHVSSVTIMSRTHAPGESPRIV-DVKEQRLSGFF--VCLMIGLSVLMAPLLRLIPMAVLFGVF 1152
            |..|:.::..:....:.|....:: :|:|.||:...  |.:::.:..|:...|:|||.:||.|:|
 Worm   878 SPLHLRALADVEERVSQGHVHEVIMNVRETRLASLIAHVMILVSMFFLIPYPLQLIPTSVLHGLF 942

  Fly  1153 LYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQF-- 1215
            |||.:.|:||.::|||:.|.....:.||||.|::::...|:||||..|:|.|::|.:...|.:
 Worm   943 LYMALTSLSGNEMFERLLLLITEQQAYPPTHYIRKVPQRKVHLFTACQLLQLIILCAFGFSPYPF 1007

  Fly  1216 -SLAFPFFLIMMVPIRQNL-TKLYKPEEMQALDG 1247
             .:.||......:|||..| .:|...:.:.||||
 Worm  1008 IEMVFPIVCFFFLPIRHTLIPRLIDYKYLDALDG 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	229/1022 (22%)
abts-3	NP_001355414.1	HCO3_cotransp	501..989	CDD:460009	144/513 (28%)