DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ae2 and slc4a3

DIOPT Version :9

Sequence 1:	NP_648357.1	Gene:	Ae2 / 39147	FlyBaseID:	FBgn0036043	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_017945570.1	Gene:	slc4a3 / 100495394	XenbaseID:	XB-GENE-996901	Length:	991	Species:	Xenopus tropicalis

Alignment Length:	1115	Identity:	453/1115 - (40%)
Similarity:	655/1115 - (58%)	Gaps:	169/1115 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 NKLEENGDAGAR-RISVQPED-----TALEEADLNE-LRSHRS-----------DDPRALRRHKI 227
            |:|.....|... |.||..||     ...|:.||.| :::|.:           ||...||||..
Frog    17 NELSRKESASRNMRNSVGHEDFEEFVLDFEDYDLWESIKTHLNDPEGTSSCVNLDDQSTLRRHIA 81

  Fly   228 HHSSIKLRELPQITISPFTNKKPEVDHSPHEIFVQLDELTGVGEDR-EWKETARWIKYEEDVEEG 291
            ..:.:..:| |.||...:|..|.:.|..|||:||:|:||...|..: :|:|||||||:||:||:.
Frog    82 AKNRVSRKE-PTITAPIWTRAKRKRDKGPHEVFVELNELICEGVHKMQWRETARWIKFEENVEQE 145

  Fly   292 SDRWGKPHVASLSFHSLLNLRRCLETGVVLLDLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMR 356
            :.||||||||||||.|||.||:.:..|.:.|||.:..:|.:...:|:.||:.:.|...|:.||.|
Frog   146 TSRWGKPHVASLSFRSLLELRKTITNGTLFLDLEQTTMPRIVQTIVDTMVVSEQIGACDRASVQR 210

  Fly   357 SLLLRHRHVNEHQGVLPFTKRKYNSYTSLQFLWMGADSAHQPYQQAQPPPRNLAKARRSICVTSS 421
            :|||:|.|.|:                       |.::.|         ||:...:.....:.::
Frog   211 ALLLKHSHPND-----------------------GREAHH---------PRSSTGSSTGNHLENN 243

  Fly   422 APPTAAMLNVATATAAAAAIDHRRHSTMSYLGNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKD 486
            :||.....:             :.|...|....|:|.:..::|
Frog   244 SPPIENSFS-------------KSHDADSKQKTLNGPEGHRMK---------------------- 273

  Fly   487 DMYSSSQEDLKKLQNDTILKRIPAGAEATTVLVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPV 551
                          :..::::||..||||.||||.|:||||...|||||.|.||:.::.|||:||
Frog   274 --------------HWKLMEKIPENAEATVVLVGCVDFLEQAATAFVRLDEAVLLESVLEVPIPV 324

  Fly   552 RFMFVLLGPRNFDLDYHEVGRSISTLMANEHFHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWD 616
            ||::|||||...::||||:||||||||:::.||..||.|..|:|||:|||||||.|:||||....
Frog   325 RFLYVLLGPTQANMDYHEIGRSISTLMSDKVFHEAAYTAAGRQDLLNAINEFLDCSMVLPPCEMQ 389

  Fly   617 RHDLLPFEELKA-KKDWIRTRKIKALQVKRDSEMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGG 680
            ..|||  ..:.| :||.:|.|        |:.|..:..::.....::.|::.|....       .
Frog   390 SKDLL--RSIAAFQKDLLRKR--------REREQRRSARENVPPTVQGQSVEARQLK-------P 437

  Fly   681 DGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACLST 745
            |.:.||::     :..|||::|.|:|||..|::||...|.|||.||||::.|||.:|:|||.||.
Frog   438 DDEEDDES-----QSDPLERSGYLFGGLVRDIRRRYVKYWSDIKDGLNSQCLAAALFIYFAALSP 497

  Fly   746 AITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEF 810
            |||||||:..||...:|:||.::|.|::|::|..|:.|||:|:|.:||||:|:||...||...|.
Frog   498 AITFGGLLGEKTQGLMGVSELIVSTSVLGVIFALLAAQPLLIVGFSGPLLVFEEAFFKFCQVQEI 562

  Fly   811 DFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETFMKLISIYRENPL 875
            ::|:.||::|.|||...|.:.|.|||..||.::.||||||:.||:||:|.|||.||..::.|:||
Frog   563 EYLTGRVWIGFWLIFFILVMVAAEGSFLVRYISPFTQEIFAFLISLIFIHETFYKLYKVFAEHPL 627

  Fly   876 LSDYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQPNTALFCTI 940
            |..|   ||.         .:::..||::.                      |:.||||||...|
Frog   628 LRTY---PPV---------GAVVGRTAALG----------------------PRMQPNTALLSLI 658

  Fly   941 LTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPS 1005
            |.:.||::|::|:.|:||.|||..|||.:||||:||||.:.|.:||.:...||:||.||.|||.:
Frog   659 LMVGTFLIAFFLRKFKNSRFLGGQARRVIGDFGIPISILVMVFIDYAITDTYTQKLNVPSGLSVT 723

  Fly  1006 DPSKRGWYIGFDTSST------WIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHW 1064
            .|.||||:|  |...|      |:.||..||||||:||:|||:||:.|||.:.:|.|:||||.|.
Frog   724 SPGKRGWFI--DPMGTSKPFPLWMMFASAIPALLVFILMFMETQITTLIVSRKERRLQKGSGFHL 786

  Fly  1065 DIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLM 1129
            |::|:..|...|.:||:||..|.|||||||::::|:||:| ||||.|||.:|||||::...:..:
Frog   787 DLLLIGSLGGVCALFGLPWLTATTVRSVTHINALTVMSKT-APGEKPRIAEVKEQRVTAVLISAL 850

  Fly  1130 IGLSVLMAPLLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLH 1194
            :|||::|..:||.||:|||||:||||||.|::|:|||||:.|..|..||:|...||.::..|::|
Frog   851 VGLSIVMGEMLRQIPLAVLFGIFLYMGVTSLTGIQLFERLLLILMHPKHHPEHPYVVKVCTWRMH 915

  Fly  1195 LFTTIQVLCLVLLWSVKSSQFSLAFPFFLIMMVPIRQ-NLTKLYKPEEMQALDGSEMKKN-DDDE 1257
            |||.:|:.|:|:||.||||..||||||.||:.||:|: .|.:.::..|::|||..:::.| |:|.
Frog   916 LFTCVQLSCIVILWVVKSSPASLAFPFLLILTVPLRRFVLPRFFQERELKALDSEDVEPNFDEDG 980

  Fly  1258 PDFYEQTNIP 1267
            .|.|.:.::|
Frog   981 RDEYNELHMP 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	ae	260..1267	CDD:273290	423/1016 (42%)
		Band_3_cyto	287..618	CDD:284893	117/330 (35%)
		HCO3_cotransp	698..1199	CDD:279322	244/506 (48%)
slc4a3	XP_017945570.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2433
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	803	1.000	Inparanoid score	I489
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D173913at33208
OrthoFinder	1	1.000	-	-		FOG0000136
OrthoInspector	1	1.000	-	-		otm48864
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X102
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060