Protein Alignment Ae2 and slc4a4

DIOPT Version :10

• Sequence 1: NP_648357.1
• Gene: Ae2 / 39147
• FlyBaseID: FBgn0036043
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_004919190.2
• Gene: slc4a4 / 100490445
• XenbaseID: XB-GENE-479125
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 1163
• Identity: 401/1163 - (34%)
• Similarity: 616/1163 - (52%)
• Gaps: 165/1163 - (14%)

  Fly   146 DEQPTDQSHE-----------RKRRRSRHQYYRQRKFSHQDSVEPKNKLEENGDAGARRISVQPE 199
            ||:..:..|.           |:|||.||      :..|::..| |.|..||
 Frog    19 DEEEVEGHHTVYIGVHVPKSYRRRRRHRH------RTGHKEKKE-KEKSSEN------------- 63

  Fly   200 DTALEEADLNELRSHRSDDPRALRRHKIHHSSIKLRELPQITISP------FTNKKPEVDHSPHE 258
                 .:||::..:..:|:.          ||..|:.|    |||      |...:.:...:|.:
 Frog    64 -----YSDLDKSDTENADET----------SSSILKPL----ISPAAERIRFILGEDDDSPAPPQ 109

  Fly   259 IFVQLDELTGV-GEDREWKETARWIKYEEDVEEGSDRWGKPHVASLSFHSLLNLRRCLETGVVLL 322
            :|.:||||..| |::.||||||||:|:||.||:|.:||.|||||:||.|||..||.|:|.|.:||
 Frog   110 LFTELDELLSVDGQEMEWKETARWLKFEEKVEQGGERWSKPHVATLSLHSLFELRTCIEKGTILL 174

  Fly   323 DLNEKDLPAVAYRVVEQMVIEDLIDINDKPSVMRSLLLRHRHVNEHQGVLPFTKRKYNSYTSLQF 387
            ||....||.|..::::..:...|:....|..|..:||.:|||           :.|.::..||..
 Frog   175 DLEANSLPQVVEKILDNQIETGLLKAELKDKVTYTLLRKHRH-----------QTKKSNLRSLAD 228

  Fly   388 LWMGADSAHQPYQQAQPPPRNLAKARRSICVTSSAPPTAAMLNVATATAAAAAIDHRRHSTMSYL 452
            :.....||.:.:.......|.....:.|. :::.:|...::..:||..:
 Frog   229 IGKTVSSASRMFTSPDNGVREEGLVKNSF-LSARSPLETSVPCLATRMS---------------- 276

  Fly   453 GNLSGTDDKKIKIMPAAEIGGSKRSNELKIDMKDDMYSSSQEDLKKLQNDTILKRIPAGAEATTV 517
                 .||.:::..|:..:..|...:...:........|.:.|..:|:| ..:|:||..|||:.|
 Frog   277 -----DDDLRVRRSPSMGLLSSPTMSPRNLTSSSLNDISDKPDKDQLKN-KFMKKIPRDAEASNV 335

  Fly   518 LVGAVEFLEQPTIAFVRLSEGVLMPTLTEVPVPVRFMFVLLGPRNFDLDYHEVGRSISTLMANEH 582
            |||.|:|||.|.||||||.:.|:...|||||||.||:|:||||:.....|||:||||:|||::|.
 Frog   336 LVGEVDFLETPFIAFVRLQQAVMFGALTEVPVPTRFLFILLGPKGKAKSYHEIGRSIATLMSDEV 400

  Fly   583 FHSIAYKADDRKDLLSAINEFLDDSIVLPPGNWDRHDLLPFEELKAKKDWIRTRKIKALQVKRDS 647
            ||.|||||.||:||::.|:||||:.||||||.||     |...::..|....:.|.|.:..  ..
 Frog   401 FHDIAYKAKDRQDLIAGIDEFLDEVIVLPPGEWD-----PAIRIEPPKSIPSSDKRKNMYA--GG 458

  Fly   648 EMIKIGKDEEKALLEKQTLGAIGFTIGGGDGGGDGDSDDDNGRKKKKPSPLEKTGRLWGGLRNDL 712
            |.:::..|    .|..:          |..|||.||..:           |::|||..|||..|:
 Frog   459 ENVQMNGD----TLHDE----------GHGGGGHGDCPE-----------LKRTGRFCGGLVEDI 498

  Fly   713 KRRMPMYKSDILDGLNTETLAATIFMYFACLSTAITFGGLVSAKTNSWIGISETLISCSLVGIVF 777
            ||:.|.:.||..|.|:.::|:|.:|:|...::.|||||||:...|.:..|:.|:.:..::.|.||
 Frog   499 KRKAPYFASDFYDALSIQSLSAMLFIYLGTVTNAITFGGLLGDATENMQGVLESFLGTAISGAVF 563

  Fly   778 HCLSCQPLVIIGTTGPLLLFDEALMVFCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLL 842
            ..|:.|||:|:.:|||:|:|:..|..|...:.||:|..|:::|:|...:.|.:.|.:.|..|:..
 Frog   564 CLLAGQPLIILSSTGPVLVFERLLFNFSRDNGFDYLEFRLWIGLWSAFLCLVLVATDASSLVKYF 628

  Fly   843 TRFTQEIFSALITLIYIVETFMKLISIYRENPLLSDYN-----------LPP-PTLVAHEHATNE 895
            ||||:|.|:.||:.|:|.:.|.|:|......|:.:.:.           ||| |..::..:.|.|
 Frog   629 TRFTEEGFACLISFIFIYDAFKKMIKFADYYPINTHFKVGDVTLFSCTCLPPDPANISLFNGTTE 693

  Fly   896 SLLNATASVTTNITQMVMNISTTAMPIGPPPLPKNQ----------------PNTALFCTILTLA 944
            |.|:   ..:|.| .|.|:.:.|   |....|.|.:                |:..|...||...
 Frog   694 SPLD---FFSTTI-DMDMDHNNT---INWSTLTKKECLKYGGNLVGNNCKYIPDITLMSFILFFG 751

  Fly   945 TFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAIFVLVDYLVPAVYTEKLVVPEGLSPSDPSK 1009
            |:..:..||.|:.|.:....||:.:.||.:.:||.||..:|.|| .|.|.||:||....|:.| .
 Frog   752 TYACSMALKKFKTSRYFPTTARKLISDFAIILSILIFCGIDALV-GVDTPKLLVPSEFKPTSP-H 814

  Fly  1010 RGWYI-GFDTSSTWIPFACVIPALLVYILIFMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLN 1073
            |||:: .|..:..|:..|..:|||||.|||||:.||:.:||::.:..||||:|.|.|:..:.:|.
 Frog   815 RGWFVPPFGGNPWWVYLAASLPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAVLM 879

  Fly  1074 CACGIFGMPWHCAATVRSVTHVSSVTIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAP 1138
            ..|....:||:.||||.|:.|:.|:.:.:.|.||||.|:.:.|:|||::|..|.::.|:||.|||
 Frog   880 IVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGVMVFILTGVSVFMAP 944

  Fly  1139 LLRLIPMAVLFGVFLYMGVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLC 1203
            :|:.|||.||:||||||||||::|||..:|::|..||.||.|...|::.:...::||||.||:||
 Frog   945 ILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPAKHQPDFIYLRHVPLRRVHLFTFIQILC 1009

  Fly  1204 LVLLWSVKSSQFSLAFPFFLIMMVPIRQNLTKLYKPEEMQALDG----SEMKKNDDDE 1257
            |.|||.:||:..::.||..::.:|.:|:.:..|:...::..||.    .:.||.:|::
 Frog  1010 LALLWILKSTVAAIIFPVMILALVAVRKAMDYLFSQHDLGFLDDVIPEKDKKKKEDEK 1067

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ae2	NP_648357.1	Band_3_cyto	260..1267	CDD:452680	374/1032 (36%)
slc4a4	XP_004919190.2	Band_3_cyto	111..1052	CDD:452680	369/1015 (36%)